A5046123788- Glioma Diagnosis and Treatment
- Neuroblastoma Research and Treatments
- Neurofibromatosis and Schwannoma Cases
- Meningioma and schwannoma management
- Testicular diseases and treatments
- Brain Metastases and Treatment
- Childhood Cancer Survivors' Quality of Life
- Chromatin Remodeling and Cancer
- Vascular Malformations Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Hedgehog Signaling Pathway Studies
- Cancer therapeutics and mechanisms
- Acute Myeloid Leukemia Research
- Histone Deacetylase Inhibitors Research
- Microtubule and mitosis dynamics
- Adrenal and Paraganglionic Tumors
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
- Neuroendocrine Tumor Research Advances
- Cancer, Hypoxia, and Metabolism
- Pharmacological Effects and Toxicity Studies
- Sarcoma Diagnosis and Treatment
- Lung Cancer Research Studies
- Ubiquitin and proteasome pathways
- Genetic and Kidney Cyst Diseases
University Hospital Augsburg
2016-2025
University of Augsburg
2020-2024
Cancer Research Center
2022
Children's Cancer Center
2019
Society of Paediatric Oncology and Haematology
2017
University of Bonn
2012-2016
University of Würzburg
2012-2016
Medical University of Vienna
2016
University Children's Hospital Zurich
2016
Leipzig University
2016
The molecular pathogenesis of pediatric astrocytomas is still poorly understood. To further understand the genetic abnormalities associated with these tumors, we performed a genome-wide analysis DNA copy number aberrations in low-grade by using array-based comparative genomic hybridization. Duplication BRAF protooncogene was most frequent aberration, and tumors duplication showed significantly increased mRNA levels downstream target, CCND1, as compared without duplication. Furthermore,...
The excellent prognosis of localized neuroblastoma in infants, the overdiagnosis observed screening studies, and several case reports regression prompted us to initiate a prospective cooperative trial on observation without cytotoxic treatment.For infants with MYCN amplification, chemotherapy was scheduled only cases threatening symptoms; otherwise, tumor either resected or by ultrasound magnetic resonance imaging (MRI).Of 340 eligible participants, 190 underwent resection, 57 were treated...
The Hirntumorstudien (HIT)-LGG-1996 protocol offered a comprehensive treatment strategy for pediatric patients with low-grade glioma (LGG), ie, observation, surgery, adjuvant radiotherapy, and chemotherapy to defer the start of irradiation in young children. In this current study, we sought determine clinical factors progression survival. Between October 1, 1996 March 31, 2004, 1031 were prospectively recruited into an observation arm (n = 668) nonsurgical stratifying 12 months...
The large diversity of central nervous system (CNS) tumor types in children and adolescents results disparate patient outcomes renders accurate diagnosis challenging. In this study, we prospectively integrated DNA methylation profiling targeted gene panel sequencing with blinded neuropathological reference diagnostics for a population-based cohort more than 1,200 newly diagnosed pediatric patients CNS tumors, to assess their utility routine neuropathology. We show that the multi-omic...
Abstract In a multicentre randomised clinical trial 364 children with biopsy proven medulloblastoma were randomly assigned to receive or not pre‐radiotherapy chemotherapy. Children total subtotal removal of the tumour, no evidence invasive brain stem involvement, and metastatic disease either within without cranium designated “low risk”, those gross residual involvement metastases in central nervous system “high risk”. All prescribed 55 Gy tumour bearing area. “Low risk” could be “standard”...
To investigate the utility of postoperative chemotherapy in delaying radiotherapy and to identify prognostic factors early childhood medulloblastoma, we studied children younger than 3 years age registered HIT-SKK'87 (Therapieprotokoll für Säuglinge und Kleinkinder mit Hirntumoren [Brain Tumor Radiotherapy for Infants Toddlers with Medulloblastoma] 1987) trial who received systemic interval until craniospinal was applied at or relapse, from 1987 1993. Children residual tumor metastatic...
Abstract BACKGROUND: The authors hypothesized that intensified chemotherapy in protocol HIT‐GBM‐C would increase survival of pediatric patients with high‐grade glioma (HGG) and diffuse intrinsic pontine (DIPG). METHODS: Pediatric newly diagnosed HGG DIPG were treated standard fractionated radiation simultaneous (cisplatin 20 mg/m 2 × 5 days, etoposide 100 3 vincristine, 1 cycle cisplatin + ifosfamide 1.5 g/m days [PEI] during the last week radiation). Subsequent maintenance included further...
<h2>Abstract</h2><h3>Background</h3> The use of chemotherapy to manage newly diagnosed low grade glioma (LGG) was first introduced in the 1980s. One randomised trial has studied two- versus four-drug regimens with a duration 12 months treatment after resection. <h3>Methods</h3> Within European comprehensive strategy for childhood LGG, International Society Paediatric Oncology–Low Grade Glioma (SIOP LGG) Committee launched involving 118 institutions and 11 countries investigate addition...
Thromboembolism is a serious complication of induction therapy for childhood acute lymphoblastic leukemia. We prospectively compared the efficacy and safety antithrombotic interventions in consecutive leukemia trials ALL-BFM 2000 AIEOP-BFM ALL 2009. Patients with newly diagnosed (n=949, age 1 to 18 years) were randomized receive low-dose unfractionated heparin, prophylactic low molecular weight heparin (enoxaparin) or activity-adapted antithrombin throughout therapy. The primary objective...
Abstract Introduction A hallmark of pediatric low-grade glioma (pLGG) is aberrant signaling the mitogen activated protein kinase (MAPK) pathway. Hence, inhibition MAPK using small molecule inhibitors such as MEK (MEKi) may be a promising strategy. Methods In this multi-center retrospective centrally reviewed study, we analyzed 18 patients treated with MEKi trametinib for progressive pLGG an individual treatment decision between 2015 and 2019. We have investigated radiological response per...
Background: Low grade gliomas arise in all CNS-locations and age groups, chiasmatic-hypothalamic tumors occur especially young children. Early radiotherapy (RT) shall be deferred by chemotherapy (CT) within the concept of HIT-LGG 1996 study, offering a comprehensive treatment strategy for groups. Patients: 198 905 protocol patients (21.9 %) had chiasmatic (34), (144) or hypothalamic (20) primary tumor, median at diagnosis 3.6 years (0.2-16.3 y.), 54 neurofibromatosis (27.3 %), 108 female...
Low grade gliomas (LGGs) constitute the largest, yet clinically and (molecular-) histologically heterogeneous group of pediatric brain tumors WHO grades I II occurring throughout all age groups at central nervous system (CNS) sites. The are characterized by a slow growth rate may show periods arrest. Around 40% LGG patients can be cured complete neurosurgical resection followed close observation. In case relapse, second often is possible. Following incomplete observation recommended, as long...
Abstract BACKGROUND To evaluate the feasibility and efficacy of intensive chemotherapy given prior to irradiation in pediatric patients with malignant glioma, Society Pediatric Oncology Germany started a randomized trial 1991. The high‐grade glioma strata had be closed because insufficient patient accrual. follow‐up data from these are reported. METHODS Fifty‐two World Health Organization (WHO) Grade 4 ( n = 27 patients) or WHO 3 anaplastic astrocytoma 25 between ages years 17 were available...
Since its constitution during the 22nd annual meeting of International Society Pediatric Oncology in Rome 1990, Brain Tumor Subcommittee has worked to arrive at a consensus for reporting criteria that should be adopted when brain tumor trials are presented. This is presented here concerning minimum requirements diagnostic procedures and systematic approach define extent surgically achieved resection by radiodiagnostic classification aided surgical report as well response remission criteria.
A subset of poorly differentiated squamous cell carcinomas, NUT midline carcinomas (NMC) are characterized by a translocation t(15;19)(q13;p13) [1 French CA, Miyoshi I, Kubonishi et al. BRD4-NUT fusion oncogene: novel mechanism in aggressive carcinoma. Cancer Res. 2003;63(2):304–307.[PubMed], [Web Science ®] , [Google Scholar]]. The prognosis is generally dismal [2 Bauer DE, Mitchell CM, Strait KM, Clinicopathologic features and long-term outcomes Clin 2012;18(20):5773–5779.[Crossref],...
Abstract Pleomorphic xanthoastrocytoma (PXA) is a rare astrocytoma predominantly affecting children and young adults. We performed comprehensive genomic characterization on cohort of 67 patients with histologically defined PXA (n = 53, 79%) or anaplastic (A‐PXA, n 14, 21%), including copy number analysis (ThermoFisher Oncoscan, 67), methylation profiling (Illumina EPIC array, 43) targeted next generation sequencing 32). The most frequent alterations were CDKN2A/B deletion 63; 94%) BRAF...
Preradiation chemotherapy could be beneficial in malignant brain tumors, because the blood-brain tumor-barrier is disrupted after surgery, bone marrow recovery--essential for intense chemotherapy--is still intact, and CNS toxicity ototoxicity of active drugs are lower before irradiation a child's brain.A neoadjuvant phase 2 single arm pilot trial were initiated to investigate efficacy an multidrug regimen radiotherapy 147 patients aged between 3 29; 9 years with medulloblastoma (94), glioma...