A5037702813- Glioma Diagnosis and Treatment
- Classical Antiquity Studies
- Neuroblastoma Research and Treatments
- Ancient Mediterranean Archaeology and History
- Archaeology and Historical Studies
- Chromatin Remodeling and Cancer
- Childhood Cancer Survivors' Quality of Life
- Immunodeficiency and Autoimmune Disorders
- Colorectal Cancer Treatments and Studies
- Acute Lymphoblastic Leukemia research
- Lung Cancer Treatments and Mutations
- Law, logistics, and international trade
- Cancer, Hypoxia, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Neutropenia and Cancer Infections
- Historical and Archaeological Studies
- Cancer Genomics and Diagnostics
- Classical Studies and Legal History
- Histone Deacetylase Inhibitors Research
- Blood transfusion and management
- Comparative and International Law Studies
- Artificial Intelligence in Healthcare and Education
- Pregnancy-related medical research
- Antibiotic Use and Resistance
- Amoebic Infections and Treatments
University Hospital Heidelberg
2013-2023
Heidelberg University
2013-2023
National Center for Tumor Diseases
2015-2023
Hopp Children's Cancer Center Heidelberg
2018-2023
German Cancer Research Center
2014-2023
Deutschen Konsortium für Translationale Krebsforschung
2023
Leiden University
2007-2020
Wilhelmina Children's Hospital
2009
University Medical Center Utrecht
2009
Low grade gliomas (LGGs) constitute the largest, yet clinically and (molecular-) histologically heterogeneous group of pediatric brain tumors WHO grades I II occurring throughout all age groups at central nervous system (CNS) sites. The are characterized by a slow growth rate may show periods arrest. Around 40% LGG patients can be cured complete neurosurgical resection followed close observation. In case relapse, second often is possible. Following incomplete observation recommended, as long...
The third multistakeholder Paediatric Strategy Forum organised by ACCELERATE and the European Medicines Agency focused on immune checkpoint inhibitors for use in combination therapy children adolescents. As inhibitors, both as monotherapy combinations have shown impressive success some adult malignancies early phase trials of single agent now been completed, it seemed an appropriate time to consider opportunities paediatric studies used combination. Among patients, clinical demonstrated a...
Abstract Central nervous system (CNS) tumors account for the highest mortality among pediatric malignancies. Accurate diagnosis is essential optimal clinical management. The increasing use of molecular diagnostics has opened up novel possibilities more precise classification CNS tumors. We here report a single-institutional collection tumor cases that underwent refinement or change after completion analysis affected decision-making including application molecularly informed targeted...
Abstract BACKGROUND Genomic alterations and dysregulation of RAF are the main oncogenic driver in almost all pediatric low-grade gliomas (pLGGs). About 50%‒60% pLGGs harbor KIAA1549-BRAF fusion 5%‒15% BRAF V600E mutation. No targeted therapy has received regulatory approval for either relapsed or newly diagnosed pLGG to date. Tovorafenib is an investigational, oral, selective, CNS-penetrant, small molecule, type II panRAF inhibitor. The registrational, phase 2 FIREFLY-1 (NCT04775485) study...
Abstract BACKGROUND Larotrectinib is a highly selective TRK inhibitor approved for tumor-agnostic use in patients with various tumor types, including primary CNS tumors. Here, we report the independent central review and updated data on fusion-positive METHODS Patients fusion tumors enrolled two clinical trials (NCT02637687, NCT02576431) were included. Responses committee (IRC)-assessed. RESULTS As of July 2022, 41 eligible response assessment by IRC. The median age at enrollment was 11...
The founding of a city requires certain hygienic and meteorological conditions. climate must be moderate, neither too hot, nor cold; dry, moist; fresh air water are crucial. Ancient medical writers such as the authors Hippocratic Corpus, Celsus Galen prescribe ideal conditions for city. Wind-directions, local (heat, cold, humidity), quantity quality clean environment were crucial factors to establish healthy Did their opinions correspond with non-medical ancient sources like Vitruvius,...
BACKGROUND: Although childhood malignancies have become curable in about 75% of cases due to empirically developed multi-modal therapeutic concepts applied nation-wide collaborative trials, for children with a relapse, cure remains the exception. In framework ICGC project PedBrain many new potentially druggable genetic lesions been identified. However, it will not be feasible conduct traditional phase I trials all these drugs overall rare entities. To still our young patients participating...
Introduction: Relapsed tumors in pediatric oncology remain a therapeutic challenge over the past decades. With advancement of novel high throughput molecular technologies including next generation sequencing, druggableoncogenetic driver mutation can potentially be detected cost effective manner. We initiated INFORM (INdividualized therapy FOr Malignancies childhood) comprising nation-wide consortium several study groups German Society Pediatric Oncology and Hematology (GPOH). aims to provide...
Introduction: Histone deacetylases (HDACs) are key enzymes controlling epigenetic and cytoplasmatic signalling pathways involved in apoptosis, differentiation, cell cycle control drug resistance. Our group has previously shown that single members of the HDAC family 1 – 11harbor important functions pediatric pre-clinical neuronal cancer models highly expressed a pediatrictumor samples. In this multi-center phase I/II trial, patients with relapsed solid tumors, lymphoma or leukemias treated...
Introduction: Relapsed high grade malignancies in children have a fatal prognosis requiring novel treatment concepts. We launched the national INFORM (Individualized Therapy for Children with Malignancies) program to address this unmet medical need within GPOH.