A5114734282- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Cancer, Hypoxia, and Metabolism
- Cancer Genomics and Diagnostics
- Glioma Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Cancer-related Molecular Pathways
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Renal cell carcinoma treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cardiovascular Disease and Adiposity
- Mesenchymal stem cell research
- Renal and related cancers
- Vascular Malformations and Hemangiomas
- Virus-based gene therapy research
- Pituitary Gland Disorders and Treatments
- Viral Infectious Diseases and Gene Expression in Insects
- Diabetes, Cardiovascular Risks, and Lipoproteins
- MicroRNA in disease regulation
- Cancer Immunotherapy and Biomarkers
- Adipokines, Inflammation, and Metabolic Diseases
- Brain Metastases and Treatment
- Inflammatory Biomarkers in Disease Prognosis
Mayo Clinic
2010-2025
Mayo Clinic in Arizona
2011-2023
WinnMed
2011-2021
University of Padua
2020
University of Ottawa
2020
Duke University
2020
Dell Children's Medical Center of Central Texas
2019
University of Novi Sad
2018
National Institutes of Health
2011-2016
Memorial Sloan Kettering Cancer Center
2016
The immunosuppressive properties of morbilliviruses including measles and canine distemper virus (CDV) are well known, but the host cells supporting infection poorly characterized. To identify these cells, a recombinant CDV expressing green fluorescent protein was produced by reverse genetics based on wild-type strain lethal for ferrets. This fully retained virulence blazed three lymphocyte-based pathways through immune system its host: first, it infected rapidly massively circulating B T...
Purpose To present data on the high rate of SDHB mutations in patients with metastatic pheochromocytoma/paraganglioma whose initial tumor presentation began childhood or adolescence. Patients and Methods From 2000 to 2010, 263 were evaluated through National Institutes Health (NIH), Bethesda, MD. Of patients, 125 found have disease; these 32 presented a before 20 years age. An additional 17 age but demonstrated no development disease. Genetic testing for VHL, MEN, SDHB/C/D genes was...
Abstract Pleomorphic xanthoastrocytoma (PXA) is a rare astrocytoma predominantly affecting children and young adults. We performed comprehensive genomic characterization on cohort of 67 patients with histologically defined PXA (n = 53, 79%) or anaplastic (A‐PXA, n 14, 21%), including copy number analysis (ThermoFisher Oncoscan, 67), methylation profiling (Illumina EPIC array, 43) targeted next generation sequencing 32). The most frequent alterations were CDKN2A/B deletion 63; 94%) BRAF...
Anaplastic thyroid carcinoma (ATC) is a highly aggressive in need of therapeutic options. One critical component drug discovery the availability well-characterized cell lines for identification molecular mechanisms related to tumor biology and responsiveness. Up 42% human cancer are redundant or not correct tissue origin, comprehensive analysis currently nonexistent. Mechanistically, RhoB has been identified as novel target ATC therapy.The aim was develop four detailing genetic, molecular,...
Diabetes mellitus (DM) with its micro- and macrocomplications is the leading global epidemic of 21st century. The aim research to determine possible changes in complete blood count (CBC) parameters depending on glycemic controlin patients Type 2 diabetes (T2DM).
Context: The BRAFT1799A transversion is the most frequent morphotype-specific somatic mutation in papillary thyroid carcinoma (PTC). ability to detect this circulation could aid diagnosis and follow-up of PTC patients.
Eur J Clin Invest 2011; 41 (10): 1121–1128 Abstract Background Pheochromocytomas are tumours arising from chromaffin tissue located in the adrenal medulla associated with typical symptoms and signs which may occasionally develop metastases, defined as presence of tumour cells at sites where these not found. This retrospective analysis was focused on clinical, genetic histopathologic characteristics primary metastatic versus benign pheochromocytomas. Materials methods We identified subjects...
Organ of Zuckerkandl paragangliomas (PGLs) are rare neuroendocrine tumors that derived from chromaffin cells located around the origin inferior mesenteric artery extending to level aortic bifurcation. Mutations in genes encoding succinate dehydrogenase subunits (SDH) B, C, and D (SDHx) have been associated with PGLs, but their contribution PGLs organ is not known. We aimed describe clinical presentation patients investigate prevalence SDHx mutations other genetic defects among them. The...
In vitro studies have demonstrated that the PAX8/PPARγ fusion protein (PPFP), which occurs frequently in follicular thyroid carcinomas (FTC), exhibits oncogenic activity. However, paradoxically, a meta-analysis of extant tumor outcome indicates 68% FTC-expressing PPFP are minimally invasive compared to only 32% those lacking (χ2 = 6.86, P 0.008), suggesting favorably impacts FTC outcomes. designed distinguish benign neoplasms from carcinomas, previously identified suppressor miR-122, major...
Abstract MAPK pathway activation has been recurrently observed in desmoplastic infantile ganglioglioma/astrocytoma (DIG/DIA) with reported disproportionally low mutation allele frequencies relative to the apparent high tumor content, suggesting that alterations may be subclonal. We sought expand number of molecularly profiled cases and investigate if cell composition could account for frequencies. Molecular (targeted neuro-oncology next-generation sequencing/RNA sequencing OncoScan...
Background and Aims: Early identification of malignant biliary strictures (MBSs) is challenging, with up to 20% classified as indeterminants after preliminary testing tissue sampling endoscopic retrograde cholangiopancreatography. We aimed evaluate the use methylated DNA markers (MDMs) from brushings enhance MBS detection in a prospective cohort. Approach: Candidate MDMs were evaluated for their utility diagnosis through series discovery validation phases. was extracted brushing samples,...
To investigate the molecular underpinnings of thyroid cancer, preclinical cell line models are crucial; however, ∼40% these have been proven to be either duplicates existing lines or even nonthyroid-derived not derived from humans at all. Therefore, we set out establish procedures and guidelines that should proactively avoid problems, which facilitated creation criteria make valid for cancer research.Based on our recommendations, systematically characterized all new generated by a...
Vascular endothelial growth factor-targeted kinase inhibitors have emerged as highly promising therapies for radioiodine-refractory metastatic differentiated thyroid cancer. Unfortunately, drug resistance uniformly develops, limiting their therapeutic efficacies and thereby constituting a major clinical problem.To study acquired elucidate underlying mechanisms in this setting, BHP2-7 human cancer cells were subjected to prolonged continuous vitro selection with 18 μM pazopanib, clinically...
Insulin-like growth factor-1 (IGF-1) measurement by high-resolution accurate mass-mass spectrometry (HRAM-MS) is replacing IGF-1 immunoassays and allows for identification of single amino acid variants; contrast, both normal deleterious sequence variants might be missed or non-HRAM-MS methods. We have developed an intact molecule HRAM-MS method to identify variants, distinguishing them a center mass (COM) calculation, followed various tandem-MS activation techniques (HCD, ETD, ETciD, EThcD,...