A5011053726- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Fibroblast Growth Factor Research
- Pediatric Hepatobiliary Diseases and Treatments
- Liver Diseases and Immunity
- Esophageal Cancer Research and Treatment
- Glioma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Neuroblastoma Research and Treatments
- Gastrointestinal Tumor Research and Treatment
- Neurofibromatosis and Schwannoma Cases
- Chromatin Remodeling and Cancer
- Proteoglycans and glycosaminoglycans research
- Eosinophilic Disorders and Syndromes
- Molecular Biology Techniques and Applications
- Renal and related cancers
- Gastric Cancer Management and Outcomes
- Medical Imaging and Pathology Studies
- Esophageal and GI Pathology
- Cancer Mechanisms and Therapy
- Breast Lesions and Carcinomas
- Metastasis and carcinoma case studies
- Genomics and Phylogenetic Studies
Mayo Clinic
2014-2024
WinnMed
2021-2024
Molina Center for Energy and the Environment
2022
Mayo Clinic in Arizona
2005-2021
Dell Children's Medical Center of Central Texas
2019
Virginia Commonwealth University
2013
Mount Sinai Hospital
2013
University of Vermont
2013
Massachusetts General Hospital
2013
Northwestern Memorial Hospital
2006
Advanced cholangiocarcinoma continues to harbor a difficult prognosis and therapeutic options have been limited. During the course of clinical trial whole genomic sequencing seeking druggable targets, we examined six patients with advanced cholangiocarcinoma. Integrated genome-wide transcriptome sequence analyses were performed on tumors from advanced, sporadic intrahepatic (SIC) identify potential therapeutically actionable events. Among somatic events captured in our analysis, uncovered...
Patients with primary sclerosing cholangitis (PSC) are at increased risk for developing cholangiocarcinoma (CCA). Fluorescence in situ hybridization (FISH) is a cytological test designed to enhance early CCA diagnosis. The long-term outcome of PSC patients positive FISH (polysomy, trisomy/tetrasomy) unclear. All least one were identified and defined have if they had tissue biopsy, cytology, or evidence cancer the explant after liver transplantation. A total 235 performed, 56 on...
Objectives: Brush cytology has a low sensitivity for the diagnosis of cholangiocarcinoma. This study aimed to compare standard approach (brush cytology) with triple modality utilizing brush cytology, forceps biopsy and fluorescence in situ hybridization terms specificity Methods: In retrospective at single academic center, 50 patients underwent testing. Additionally, 61 alone. Intervention was endoscopic retrograde cholangiopancreatography hybridization, biopsy. The main outcome measures...
BACKGROUND Patients diagnosed with primary sclerosing cholangitis (PSC) and dominant strictures often undergo endoscopic retrograde cholangiopancreatography brush cytology to exclude or confirm the development of malignancy. Equivocal (atypical suspicious) routine cytologic results may confound patient management decisions, especially in absence a mass on imaging. The objective current study was identify independent predictors malignancy patients PSC an equivocal diagnosis. METHODS underwent...
Abstract Background Glioblastoma (GBM) represents an aggressive cancer type with a median survival of only 14 months. With fewer than 5% patients surviving 5 years, comprehensive profiling these rare could elucidate prognostic biomarkers that may confer better patient outcomes. We utilized multiple molecular approaches to characterize the largest cohort isocitrate dehydrogenase (IDH)–wildtype GBM long-term survivors (LTS) date. Methods Retrospective analysis was performed on 49 archived...
Polysomy detected by fluorescence in situ hybridization (FISH) is associated with cholangiocarcinoma (CCA) patients primary sclerosing cholangitis (PSC). However, a subset of PSC polysomy do not manifest CCA even after long-term follow-up. It unknown if chromosomal gains FISH multiple areas the biliary tree (i.e., multifocal polysomy, MFP) are more likely to be diagnosed than unifocal (UFP). Therefore, our aim determine whether MFP compared other abnormalities including UFP and subtypes.
Primary high-grade infiltrating gliomas of the spinal cord are rare, with prior series including limited numbers cases and reporting poor outcomes. Additionally, molecular profile has not been well characterized. We identified 13 adult patients whose surgery had performed at our institution over a 26-year-period. Radiologically, nine harbored regions post-contrast enhancement. Existing slides were reviewed, when sufficient tissue was available, immunohistochemical stains (IDH1-R132H,...
Routine cytologic (RC), fluorescence in situ hybridization (FISH), digital image analysis (DIA), and quantifiable morphometric results from 284 pancreatobiliary stricture brushings were compared. We chose specific DIA nuclear features assessed by pathologists evaluating RC specimens, such as area shape. A visual score (VNMS) was calculated. There a difference (P < .001) the mean VNMS when classified negative (11.5), atypical (12.5), suspicious (13.8), positive (16.5). The of specimens...
Cytologic evaluation of pancreatobiliary brushings is specific but poorly sensitive for malignancy. Detection polysomic cells by fluorescence in situ hybridization (FISH) significantly more than routine cytology with similar specificity. The purpose this study was to identify cytologic criteria most associated malignancy specimens unaffected sample failure. Endoscopic were split equally and FISH analyses per clinical practice. We retrospectively evaluated 16 on Papanicolaou-stained slides....