A5018026468- Glioma Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Radiomics and Machine Learning in Medical Imaging
- MicroRNA in disease regulation
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Ferroptosis and cancer prognosis
- Prostate Cancer Treatment and Research
- Cancer Cells and Metastasis
- Chemical Reactions and Isotopes
- Cancer Research and Treatments
- Chromatin Remodeling and Cancer
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Molecular Biology Techniques and Applications
- Telomeres, Telomerase, and Senescence
- 3D Printing in Biomedical Research
- Genomics and Chromatin Dynamics
- Ocular Oncology and Treatments
- CRISPR and Genetic Engineering
- Computational Drug Discovery Methods
- interferon and immune responses
- Evolution and Genetic Dynamics
- Prostate Cancer Diagnosis and Treatment
- Click Chemistry and Applications
Mayo Clinic
2014-2024
Mayo Clinic in Arizona
2013-2023
WinnMed
2014-2023
Mayo Clinic in Florida
2023
University of California, San Francisco
2013-2014
Cancer Genetics (United States)
2010-2013
Neurological Surgery
2013
UCSF Helen Diller Family Comprehensive Cancer Center
2013
Gladstone Institutes
2013
University of Minnesota Rochester
2013
The prediction of clinical behavior, response to therapy, and outcome infiltrative glioma is challenging. On the basis previous studies tumor biology, we defined five molecular groups with use three alterations: mutations in TERT promoter, IDH, codeletion chromosome arms 1p 19q (1p/19q codeletion). We tested hypothesis that within based on these features, tumors would have similar variables, acquired somatic alterations, germline variants.We scored as negative or positive for each markers...
Purpose Clinicopathologic features and biochemical recurrence are sensitive, but not specific, predictors of metastatic disease lethal prostate cancer. We hypothesize that a genomic expression signature detected in the primary tumor represents true biological potential aggressive provides improved prediction early cancer metastasis. Methods A nested case-control design was used to select 639 patients from Mayo Clinic registry who underwent radical prostatectomy between 1987 2001. classifier...
No AccessJournal of UrologyAdult Urology1 Dec 2013Validation a Genomic Classifier that Predicts Metastasis Following Radical Prostatectomy in an At Risk Patient Population R. Jeffrey Karnes, Eric J. Bergstralh, Elai Davicioni, Mercedeh Ghadessi, Christine Buerki, Anirban P. Mitra, Anamaria Crisan, Nicholas Erho, Ismael A. Vergara, Lucia L. Lam, Rachel Carlson, Darby J.S. Thompson, Zaid Haddad, Benedikt Zimmermann, Thomas Sierocinski, Timothy Triche, Kollmeyer, Karla V. Ballman, Peter C....
Abstract Background Glioblastoma (GBM) exhibits profound intratumoral genetic heterogeneity. Each tumor comprises multiple genetically distinct clonal populations with different therapeutic sensitivities. This has implications for targeted therapy and informed paradigms. Contrast-enhanced (CE)-MRI conventional sampling techniques have failed to resolve this heterogeneity, particularly nonenhancing populations. study explores the feasibility of using multiparametric MRI texture analysis...
Abstract Purpose: Glioblastoma is the most frequent and lethal primary brain tumor. Development of novel therapies relies on availability relevant preclinical models. We have established a panel 96 glioblastoma patient-derived xenografts (PDX) undertaken its genomic phenotypic characterization. Experimental Design: PDXs were from glioblastoma, IDH-wildtype (n = 93), IDH-mutant 2), diffuse midline glioma, H3 K27M-mutant 1), both 60) recurrent 34) tumors. Tumor growth rates, histopathology,...
Many men develop a rising PSA after initial therapy for prostate cancer. While some of these will local or metastatic recurrence that warrants further therapy, others have no evidence disease progression. We hypothesized an expression biomarker panel can predict which with would benefit from therapy.A case-control design was used to test the association gene outcome. Systemic (SYS) progression cases were post-prostatectomy who developed systemic within 5 years recurrence. controls matched...
Establishing causal links between inherited polymorphisms and cancer risk is challenging. Here, we focus on the single-nucleotide polymorphism rs55705857, which confers a sixfold greater of isocitrate dehydrogenase (
Abstract Background Glioblastoma (GBM) represents an aggressive cancer type with a median survival of only 14 months. With fewer than 5% patients surviving 5 years, comprehensive profiling these rare could elucidate prognostic biomarkers that may confer better patient outcomes. We utilized multiple molecular approaches to characterize the largest cohort isocitrate dehydrogenase (IDH)–wildtype GBM long-term survivors (LTS) date. Methods Retrospective analysis was performed on 49 archived...
Virtual screening of chemical databases is an emerging approach in drug discovery that uses computers to dock chemicals into the active site a target identify leads through evaluation binding affinities chemicals. However, there are concerns about validity and scope reported virtual screens due lack studies show randomly selected not equally fact metalloproteins were rarely used as targets. We have performed database prototypic inhibitors farnesyltransferase (FT) with zinc present site....
Abstract Loss of heterozygosity and fluorescence in situ hybridization (FISH) studies have shown that deletions 1p 19q are highly prevalent oligodendroglioma. However, these tumors not been comprehensively screened for other alterations chromosomal dosage. In this study, we used array‐based comparative genomic (CGHa) mapped BAC DNA to screen such 31 oligodendrogliomas (20 grade II, 9 III, 2 IV) 4 mixed oligoastrocytomas (1 I, 1 IV). The most frequent aberrations were loss (17 cases; 49%) (15...
The Sleeping Beauty (SB) transposon system has been used as an insertional mutagenesis tool to identify novel cancer genes. To glioma-associated genes, we evaluated tumor formation in the brain tissue from 117 transgenic mice that had undergone constitutive SB-mediated transposition. Upon analysis, 21 samples (18%) contained neoplastic with features of high-grade astrocytomas. These tumors expressed glial markers and were histologically similar human glioma. Genomic DNA SB-induced...
Glioma risk has consistently been inversely associated with allergy history but not smoking despite putative biologic plausibility. Data from 855 high-grade glioma cases and 1,160 controls 4 geographic regions of the United States during 1997-2008 were analyzed for interactions between histories inherited variants in 5 established regions: 5p15.3 (TERT), 8q24.21 (CCDC26/MLZE), 9p21.3 (CDKN2B), 11q23.3 (PHLDB1/DDX6), 20q13.3 (RTEL1). The inverse relation was stronger among those who did (odds...
Genomewide association studies ( GWAS ) and candidate‐gene have implicated single‐nucleotide polymorphisms SNP s) in at least 45 different genes as putative glioma risk factors. Attempts to validate these associations yielded variable results few genetic factors been consistently replicated. We conducted a case‐control study of Caucasian cases controls from the University California San Francisco (810 cases, 512 controls) Mayo Clinic (852 789 an attempt replicate previously reported for...
Genome-wide association studies have implicated single nucleotide polymorphisms (SNPs) in 7 genes as glioma risk factors, including 2 (TERT, RTEL1) involved telomerase structure/function. We examined associations of these established loci with age at diagnosis among patients glioma. SNP genotype data were available for 2286 Caucasian from the University California, San Francisco (n = 1434) and Mayo Clinic 852). Regression analyses performed to test between "number alleles" "age diagnosis,"...
Abstract BACKGROUND Deletions of 19q have been associated with gliomas, especially oligodendrogliomas. In addition, cases oligodendrogliomas the deletion observed to a better survival compared without deletion. The authors previously described 150‐kilobase minimal region in gliomas that maps 19q13.33 and contains 3 novel candidate genes ( GLTSCR1 , EHD2 GLTSCR2 ). METHODS performed an association study using 141 (61 astrocytomas, 40 oligodendrogliomas, mixed oligoastrocytomas) 108 general...
Recent discoveries of inherited glioma risk loci and acquired IDH mutations are providing new insights into etiology. common in lower grade gliomas secondary glioblastomas uncommon primary glioblastomas. Because the variant 11q23 has been associated with not glioblastomas, we hypothesized that this increases susceptibility to IDH-mutated gliomas, but IDH-wild-type gliomas. We tested hypothesis patients controls from San Francisco Adult Glioma Study, Mayo Clinic, Illumina (1102 total...
Twenty-five single nucleotide polymorphisms (SNPs) are associated with adult diffuse glioma risk. We hypothesized that the inclusion of these 25 SNPs age at diagnosis and sex could estimate risk as well identify subtypes. Case-control design multinomial logistic regression were used to develop models development while accounting for histologic molecular Case-case predict isocitrate dehydrogenase (IDH) mutation status. A total 1273 cases 443 controls from Mayo Clinic in discovery set, 852 231...
Abstract Background Oligodendroglioma is genetically defined by concomitant IDH (IDH1/IDH2) mutation and whole-arm 1p/19q codeletion. Codeletion of traditionally evaluated fluorescence in situ hybridization (FISH) cannot distinguish partial from Partial codeletion called positive FISH diagnostically a “false-positive” result. Chromosomal microarray (CMA) discriminates Herein, we aimed to estimate the frequency that would lead false-positive Methods test probe coordinates were mapped onto...
Abstract Background Twenty-five germline variants are associated with adult diffuse glioma, and some of these have been shown to be particular subtypes glioma. We hypothesized that additional could identified if a genome-wide association study (GWAS) were performed by molecular subtype. Methods A total 1320 glioma cases 1889 controls used in the discovery set 799 808 validation set. Glioma classified into based on combinations isocitrate dehydrogenase (IDH) mutation, telomerase reverse...