A5091637936- Sphingolipid Metabolism and Signaling
- Influenza Virus Research Studies
- Respiratory viral infections research
- Pharmaceutical studies and practices
- Emergency and Acute Care Studies
- Pneumonia and Respiratory Infections
- Drug-Induced Adverse Reactions
- Streptococcal Infections and Treatments
- Hematological disorders and diagnostics
- Infectious Encephalopathies and Encephalitis
- Thermal Regulation in Medicine
- Medical Malpractice and Liability Issues
- Dental Education, Practice, Research
- Pharmaceutical Practices and Patient Outcomes
- Child and Adolescent Health
- Immunodeficiency and Autoimmune Disorders
- Lipid Membrane Structure and Behavior
- Protein Kinase Regulation and GTPase Signaling
- Melanoma and MAPK Pathways
- Child and Adolescent Psychosocial and Emotional Development
- Contact Dermatitis and Allergies
- Pharmaceutical industry and healthcare
- Cytokine Signaling Pathways and Interactions
- Adolescent and Pediatric Healthcare
- Pediatric Urology and Nephrology Studies
Vanderbilt University Medical Center
2022-2025
Monroe Carell Jr. Children's Hospital
2019-2024
Vanderbilt University
2019-2024
University Medical Center
2012-2024
University Hospital and Clinics
2012-2024
American Society of Safety Professionals
2023
University of Illinois Chicago
2015-2020
University of Illinois Hospital & Health Sciences System
2015-2020
University of Mississippi Medical Center
2020
State Street (United States)
2020
Little is known about the epidemiology and outcomes of neurologic complications associated with coronavirus disease 2019 (COVID-19) in children.We performed a cross-sectional study children 2 months to <18 years age COVID-19 discharged from 52 children's hospitals March 2020 2022. Neurologic were defined as encephalopathy, encephalitis, aseptic meningitis, febrile seizure, nonfebrile brain abscess bacterial Reye's syndrome, cerebral infarction. We assessed length stay (LOS), ICU...
Resistance to chemotherapy remains a significant obstacle in the treatment of hormone- independent breast cancer. Recent evidence suggests that altered sphingolipid signaling through increased sphingosine kinase activity may be an important mediator cancer drug resistance. Sphingosine kinase-1 (Sphk1) is proposed key regulator tumorigenesis, proliferation and There is, however, conflicting data on role kinase-2 (Sphk2) biology resistance, with some suggesting Sphk2 has opposing Sphk1. Here,...
Little is known about the clinical factors associated with COVID-19 disease severity in children and adolescents.We conducted a retrospective cohort study across 45 US children's hospitals between April 2020 to September of pediatric patients discharged primary diagnosis COVID-19. We assessed hospitalization (eg, admission inpatient floor, intensive care unit [ICU], ICU mechanical ventilation, shock, death) among those hospitalized.Among 19,976 encounters, 15,913 (79.7%) were from emergency...
Importance Studies of influenza in children commonly rely on coded diagnoses, yet the ability International Classification Diseases, Ninth Revision codes to identify emergency department (ED) and hospital is highly variable. The accuracy newer Statistical Diseases Related Health Problems, Tenth (ICD-10) unknown. Objective To determine ICD-10 discharge diagnosis pediatric ED inpatient settings. Design, Setting, Participants Children younger than 18 years presenting or settings with fever...
Alterations in sphingolipid metabolism have been shown to contribute the development of endocrine resistance and breast cancer tumor survival. Sphingosine kinase (SK), particular, is overexpressed a promising target for drug development. In this study, we used novel SK inhibitor ABC294640 as tool explore relationship between estrogen (E2) receptor (ER) signaling cells. Treatment with decreased E2-stimulated ERE-luciferase activity both MCF-7 ER-transfected HEK293 Furthermore, reduced...
Adult human mesenchymal stem cells (hMSC) have been shown to home sites of carcinoma and affect biological processes, including tumour growth metastasis. Previous findings conflicting a clear understanding the effects hMSCs on cancer remains be established. Therefore, we set out investigate impact oestrogen receptor positive, hormone-dependent breast cell line MCF-7. In this study, show are mediated through secreted factor(s) which enhanced by cell-hMSC contact/communication. addition...
The impact of COVID‐19 public health interventions on pediatric illnesses nationwide is unknown. We performed a multicenter, cross‐sectional study encounters at 44 children's hospitals in the United States to assess changes healthcare utilization during pandemic. pandemic was associated with substantial reductions for respiratory diseases; these large were consistent across illness subgroups. Although nonrespiratory diseases decreased as well, more modest and varied by age. Encounters among...
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are life-threatening cutaneous reactions, typically to drugs or infection. The incidence outcomes of these conditions in children unknown. objective this study was report the overall burden United States.We performed a retrospective cohort analysis adolescents younger than 18 years age using 2009 2012 Kids' Inpatient Database.We identified 1486 hospitalized with diagnosis necrolysis. national per 100 000 6.3 for syndrome,...
Background: The spectrum and incidence of influenza-associated neuropsychiatric complications are not well-characterized. objective this study was to define the specific neurologic psychiatric associated with influenza in children adolescents. Methods: We assembled a retrospective cohort 5–17 years age an outpatient or emergency department International Classification Diseases, 10th revision diagnosis enrolled Tennessee Medicaid from 2016 2020. Serious requiring hospitalization were...
Abstract microRNAs (miRNA) are regulators of cellular pathways and alterations normal miRNA expression levels have been shown to increase tumorigenesis. miR‐24 has demonstrated as having both tumor suppressive oncogenic properties depending on cell context. Here, we demonstrate a possible role for pre‐miR‐24‐2 suppressor in the MCF‐7 breast cancer line through preferential processing mature miR‐24‐2* over miR‐24. Specifically, show that ectopic cells results suppression survival vivo vitro....
Recently, crosstalk between sphingolipid signaling pathways and steroid hormones has been illuminated as a possible therapeutic target. Sphingosine kinase (SK), the key enzyme metabolizing pro-apoptotic ceramide to pro-survival sphingosine-1-phosphate (S1P), is promising target for solid tumor cancers. In this study, we examined ability of pharmacological inhibition S1P formation block estrogen targeted breast cancer therapy. We found that Sphk1/2 selective inhibitor (SK (SKI))-II, blocked...
BACKGROUND: Children with neurologic impairment (NI) are at risk for developing co-occurring chronic conditions, increasing their medical complexity and morbidity. We assessed the prevalence timing of onset those conditions in children NI. METHODS: This longitudinal analysis included 6229 born 2009 continuously enrolled Medicaid through 2015 a diagnosis NI by age 3 IBM Watson MarketScan Database. was defined an existing diagnostic code set encompassing neurologic, genetic, metabolic that...
Abstract Background Despite recommendations from CDC and ACIP, antiviral prescription for children who are at higher risk of severe influenza (including those &lt; 5 years with certain underlying conditions) in emergency departments (EDs) remains suboptimal. This study assessed changes EDs the pre-COVID-19-pandemic period to COVID-19 pandemic period. Demographic clinical characteristics influenza(1) enrolled ED laboratory confirmed influenza, stratified by periods (N=2,5001). (1) Defined...
Abstract Background Influenza-specific antivirals are recommended for all hospitalized children with suspected or confirmed influenza. However, antiviral use remains suboptimal. We investigated in influenza before the COVID-19 pandemic and during late period, as well factors associated use. Methods conducted active surveillance on &lt; 18 years old acute respiratory illness at seven pediatric centers New Vaccine Surveillance Network (12/01/2016–03/31/2020) period (07/01/2021–03/31/2023)....
BACKGROUND Despite national guidelines on appropriate antibiotic therapy, there is wide variation in decision-making for children with community-acquired pneumonia. This study sought to determine prevalence and factors associated guideline-concordant use presenting pneumonia the emergency department (ED). METHODS We enrolled aged younger than 18 years ED at 2 US children’s hospitals between September 2017 May 2019 clinical radiographic The primary outcome was as defined by 2011 Infectious...
To evaluate the prevalence of antiviral drug use in US children with influenza at high risk for complications and to identify factors associated dispensing. We conducted a retrospective cohort study outpatient visits individuals < 18 years during 2016-2020 seasons using Merative MarketScan Commercial Claims Encounter database. High-risk status was defined Infectious Disease Society America definitions included: age, specific co-morbidities, pregnancy or post-partum status, living long-term...
Endocrine resistance and metastatic progression are primary causes of treatment failure in breast cancer. While mitogen activated protein kinases (MAPKs) known to promote ligand-independent cell growth, the role MEK5-ERK5 pathway clinical carcinoma remains poorly understood. Here, we demonstrated increased ERK5 activation 30 39 (76.9%) tumor samples, as well across cancer systems. Overexpression MEK5 MCF-7 cells promoted both hormone-dependent hormone-independent tumorigenesis vitro vivo...