Paulina Sergot
A5011469132- Posttraumatic Stress Disorder Research
- Traumatic Brain Injury Research
- Migration, Health and Trauma
- Child Abuse and Trauma
- Traumatic Brain Injury and Neurovascular Disturbances
- Resilience and Mental Health
- Psychosomatic Disorders and Their Treatments
- Cardiac Arrest and Resuscitation
- Acute Ischemic Stroke Management
- Trauma and Emergency Care Studies
- Intensive Care Unit Cognitive Disorders
- Treatment of Major Depression
- Anesthesia and Neurotoxicity Research
- Tryptophan and brain disorders
- Anesthesia and Sedative Agents
- Functional Brain Connectivity Studies
- Gut microbiota and health
- Intracranial Aneurysms: Treatment and Complications
- Noise Effects and Management
- Stress Responses and Cortisol
- Cerebrovascular and Carotid Artery Diseases
- Memory and Neural Mechanisms
- Child Abuse and Related Trauma
- Cannabis and Cannabinoid Research
- Acupuncture Treatment Research Studies
The University of Texas Health Science Center at Houston
2019-2025
Texas Medical Center
2022-2024
Emory University
2022-2023
National Heart Lung and Blood Institute
2023
Park Terrace Care Center
2023
McLean Hospital
2022
Provision Healthcare
2022
Temple University
2022
University of North Carolina at Chapel Hill
2022
University of Nevada, Las Vegas
2022
Objective: Dissociation, a disruption or discontinuity in psychological functioning, is often linked with worse psychiatric symptoms; however, the prognostic value of dissociation after trauma inconsistent. Determining whether trauma-related uniquely predictive later outcomes would enable early identification at-risk populations. The authors conducted largest prospective longitudinal biomarker study persistent to date determine its capacity for adverse following acute trauma. Methods: All...
Abstract Patients exposed to trauma often experience high rates of adverse post-traumatic neuropsychiatric sequelae (APNS). The biological mechanisms promoting APNS are currently unknown, but the microbiota-gut-brain axis offers an avenue understanding as well possibilities for intervention. Microbiome composition after exposure has been poorly examined regarding outcomes. We aimed determine whether gut microbiomes trauma-exposed emergency department patients who develop have dysfunctional...
Background and Purpose The restoration of blood-flow following cerebral ischemia incites a series deleterious cascades that exacerbate neuronal injury. Pharmacologic inhibition the C3a-receptor ameliorates injury by attenuating post-ischemic inflammation. Recent reports also implicate C3a in modulation tissue repair, suggesting complement may influence both recovery at later time-points. Methods To evaluate effect antagonism on neurogenesis neurological outcome subacute period stroke,...
The complex and heterogeneous nature of traumatic brain injury (TBI) has rendered the identification diagnostic prognostic biomarkers elusive. A single acute biomarker may not be sufficient to categorize severity and/or predict outcome. Using multivariate dimension reduction analyses, we tested sensitivity specificity a multi-analyte panel proteins as an ensemble for TBI. Serum was collected within 24 h in cohort 130 patients enrolled multi-center prospective Transforming Research Clinical...
<h3>Importance</h3> A substantial proportion of the 40 million people in US who present to emergency departments (EDs) each year after traumatic events develop posttraumatic stress disorder (PTSD) or major depressive episode (MDE). Accurately identifying patients at high risk ED would facilitate targeting preventive interventions. <h3>Objectives</h3> To and validate a prediction tool based on reports motor vehicle collision predict PTSD MDE 3 months later. <h3>Design, Setting,...
Abstract Visual components of trauma memories are often vividly re-experienced by survivors with deleterious consequences for normal function. Neuroimaging research on has primarily focused threat-processing circuitry as core to trauma-related dysfunction. Conversely, limited attention been given visual which may be particularly relevant posttraumatic stress disorder (PTSD). Prior work suggests that the ventral stream is directly related cognitive and affective disturbances observed in PTSD...
Importance Adverse posttraumatic neuropsychiatric sequelae after traumatic stress exposure are common and have higher incidence among socioeconomically disadvantaged populations. Pain, depression, avoidance of trauma reminders, reexperiencing trauma, anxiety, hyperarousal, sleep disruption, nightmares been reported. Wrist-wearable devices with accelerometers capable assessing 24-hour rest-activity characteristics prevalent may utility in measuring these outcomes. Objective To evaluate...
Prior sexual trauma (ST) is associated with greater risk for posttraumatic stress disorder after a subsequent traumatic event; however, the underlying neurobiological mechanisms remain opaque. We investigated longitudinal dysfunction and amygdala functional dynamics following admission to an emergency department new primarily nonsexual in participants without previous ST. Participants (N = 2178) were recruited acute exposure (primarily motor vehicle collision). A subset (n 242) completed...
Abstract Background Residential segregation is associated with differential exposure to air pollution. Hippocampus structure and function are highly susceptible pollutants posttraumatic stress disorder (PTSD) development. Therefore, we investigated associations between residential segregation, pollutants, hippocampal neurobiology, PTSD in recent trauma survivors. Methods Participants ( N = 278; 34% non-Hispanic white, 46% Non-Hispanic Black, 16% Hispanic) completed multimodal neuroimaging...
Childhood adversity is associated with susceptibility to posttraumatic stress disorder (PTSD) in adulthood. Both PTSD and adverse experiences childhood are linked disrupted white matter microstructure, yet the role of as a potential neural mechanism connecting remains unclear. The present study investigated moderating previous on longitudinal changes microstructures symptoms following recent traumatic event As part AURORA Study, 114 trauma survivors completed diffusion weighted imaging at...
ABSTRACT PTSD is more prevalent in women than men and associated with autonomic dysfunction. Higher oestradiol levels have been decreased severity, however, the impact of on function not well characterised. We examined associations among peritraumatic multi‐site AURORA study. Participants ( n = 283, 69.6% female) were recruited from emergency department (ED) following trauma exposure. Skin conductance (SC) was measured during recall at ED. Oestradiol assayed blood collected ED, 2‐week...
Early detection of large vessel occlusion (LVO) stroke optimizes endovascular therapy and improves outcomes. Clinical severity scales used for LVO identification have variable accuracy. We investigated a portable LVO-detection device (PLD), using electroencephalography somatosensory-evoked potentials, to identify stroke.We obtained PLD data in suspected patients with enrolled prospectively via convenience sample 8 emergency departments within 24 hours symptom onset. discriminative signals...
Abstract The authors sought to characterize adverse posttraumatic neuropsychiatric sequelae (APNS) symptom trajectories across ten domains (pain, depression, sleep, nightmares, avoidance, re-experiencing, anxiety, hyperarousal, somatic, and mental/fatigue symptoms) in a large, diverse, understudied sample of motor vehicle collision (MVC) survivors. More than two thousand MVC survivors were enrolled the emergency department (ED) completed rotating battery brief smartphone-based surveys over...
Abstract Background Racial and ethnic groups in the USA differ prevalence of posttraumatic stress disorder (PTSD). Recent research however has not observed consistent racial/ethnic differences early aftermath trauma, suggesting that such chronic PTSD rates may be related to recovery over time. Methods As part multisite, longitudinal AURORA study, we investigated outcomes within 3 months after trauma. Participants ( n = 930) were recruited from emergency departments across provided periodic...
Childhood adversities (CAs) predict heightened risks of posttraumatic stress disorder (PTSD) and major depressive episode (MDE) among people exposed to adult traumatic events. Identifying which CAs put individuals at greatest risk for these adverse neuropsychiatric sequelae (APNS) is important targeting prevention interventions.
Abstract Background This is the first report on association between trauma exposure and depression from A dvancing U nderstanding of R ec O very afte traum (AURORA) multisite longitudinal study adverse post-traumatic neuropsychiatric sequelae (APNS) among participants seeking emergency department (ED) treatment in aftermath a traumatic life experience. Methods We focus presenting at EDs after motor vehicle collision (MVC), which characterizes most AURORA participants, examine associations...