A5001812810- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Cerebrospinal fluid and hydrocephalus
- Advanced Neuroimaging Techniques and Applications
- S100 Proteins and Annexins
- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Cardiac Arrest and Resuscitation
- Trauma and Emergency Care Studies
- Adipose Tissue and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Regulation of Appetite and Obesity
- MRI in cancer diagnosis
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Fetal and Pediatric Neurological Disorders
- Migraine and Headache Studies
- Face Recognition and Perception
- Menopause: Health Impacts and Treatments
- Psychosomatic Disorders and Their Treatments
- Sex and Gender in Healthcare
- Hormonal and reproductive studies
- Dementia and Cognitive Impairment Research
- Intracranial Aneurysms: Treatment and Complications
- Mesenchymal stem cell research
National Institute of Neurological Disorders and Stroke
2016-2025
National Institutes of Health
2012-2024
Johns Hopkins University
1997-2020
University of Utah
2020
Suffolk University
2020
Office of the Director
2020
Harvard University
2020
University of Rochester
2020
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2020
Massachusetts General Hospital
2020
Diffusion tensor imaging is highly sensitive to the microstructural integrity of brain and has uncovered significant abnormalities following traumatic injury not appreciated through other methods. It hoped that this increased sensitivity will aid in detection prognostication patients with injury. However, pathological substrates such changes are poorly understood. Specifically, decreases fractional anisotropy derived from diffusion consistent axonal injury, myelin or both white matter...
After central nervous system injury, inflammatory macrophages (M1) predominate over anti-inflammatory (M2). The temporal profile of M1/M2 phenotypes in and microglia after traumatic brain injury (TBI) rats is unknown. We subjected female to severe controlled cortical impact (CCI) examined the postinjury time course their brains. motor cortex (2.5 mm left laterally 1.0 anteriorly from bregma) anesthetized Wistar (ages 8 10 weeks; N = 72) underwent histologically moderate CCI with a 5-mm...
Abstract Traumatic microbleeds are small foci of hypointensity seen on T2*-weighted MRI in patients following head trauma that have previously been considered a marker axonal injury. The linear appearance and location some traumatic suggests vascular origin. aims this study were to: (i) identify characterize with acute brain injury; (ii) determine whether predict clinical outcome; (iii) describe the pathology underlying an index patient. Patients presenting to emergency department who...
Metrics of diffusion tensor imaging (DTI) and magnetization transfer (MTI) can detect diffuse axonal injury in traumatic brain (TBI). The relationship between the changes these measures underlying pathologies is still relatively unknown. This study investigated radiological-pathological correlation techniques immunohistochemistry using a closed head rat model TBI.TBI was performed on female rats followed longitudinally by magnetic resonance (MRI) out to 30 days postinjury, with subset...
Abstract Introduction Head injury is associated with significant morbidity and mortality. Long‐term associations of head dementia in community‐based populations are less clear. Methods Prospective cohort study 14,376 participants (mean age 54 years at baseline, 56% female, 27% Black, 24% injury) enrolled the Atherosclerosis Risk Communities (ARIC) Study. was defined using self‐report International Classification Diseases, Ninth/Tenth Revision (ICD‐9/10) codes. Dementia cognitive assessments,...
Acute traumatic brain injury (TBI) is associated with long-term cognitive and behavioral dysfunction. In vivo studies have shown histone deacetylase inhibitors (HDACis) to be neuroprotective following TBI in rodent models. HDACis are intriguing candidates because they capable of provoking widespread genetic changes modulation protein function. By using known a unique small-molecule pan-HDACi (LB-205), we investigated the effects mechanisms HDACi-induced neuroprotection CNS an astrocyte...
In this report, we identify existing issues and challenges related to research on traumatic brain injury (TBI) in females provide future directions for research. 2017, the National Institutes of Health, partnership with Center Neuroscience Regenerative Medicine Defense Veterans Brain Injury Center, hosted a workshop that focused unique facing researchers, clinicians, patients, other stakeholders regarding TBI women. The goal “Understanding Women” was bring together researchers clinicians...
Introduction: Elevated levels of blood-based proinflammatory cytokines are linked to acute moderate severe traumatic brain injuries (TBIs), yet less is known in mild (m)TBI cohorts. The current study examined whether can differentiate patients with mTBI, and without neuroimaging findings (CT MRI). Material Methods: Within 24 h a determined by Glasgow Coma Scale (GCS) between 13 15, participants (n = 250) underwent computed tomography (CT) magnetic resonance imaging (MRI) scan provided blood...
The complex and heterogeneous nature of traumatic brain injury (TBI) has rendered the identification diagnostic prognostic biomarkers elusive. A single acute biomarker may not be sufficient to categorize severity and/or predict outcome. Using multivariate dimension reduction analyses, we tested sensitivity specificity a multi-analyte panel proteins as an ensemble for TBI. Serum was collected within 24 h in cohort 130 patients enrolled multi-center prospective Transforming Research Clinical...
Since 2015, US government and related personnel have reported dizziness, pain, visual problems, cognitive dysfunction after experiencing intrusive sounds head pressure. The has labeled these anomalous health incidents (AHIs).
Traumatic meningeal enhancement (TME) can be observed on MRI of patients with acute traumatic brain injury (TBI) and reflects abnormal contrast extravasation into the meninges. Resolution TME occurs over time, but persist for weeks, suggesting incomplete repair. This study's objectives were to describe TME's prevalence, severity, evolution time investigate association other imaging findings, blood-based biomarkers commonly associated TBI, recovery. Patients suspected TBI presenting within 48...
White adipose tissue plays an integral role in energy metabolism and is governed by endocrine, autocrine, neural signals. Neural control of mediated sympathetic neurons that innervate the tissue. To investigate effects this innervation, ex vivo system was developed which 3T3-L1 adipocytes are cocultured with isolated from superior cervical ganglia newborn rats. In coculture, both exhibit appropriate morphology, express cell-type-specific markers, modulate key metabolic processes one another....
Stroke is a sexually dimorphic disease, with differences between males and females observed both clinically in the laboratory. While have higher incidence of stroke throughout much lifespan, aged burden stroke. Sex result from combination factors, including elements intrinsic to sex chromosomes as well effects hormone exposure lifespan. Research investigating sexual dimorphism only beginning stages, but early findings suggest that different cell death pathways are activated after ischemic A...
Traumatic cerebrovascular injury (TCVI) is a common pathologic mechanism of traumatic brain (TBI) and presents an attractive target for intervention. The aims this study were to assess cerebral blood flow (CBF) reactivity (CVR) using magnetic resonance imaging (MRI) their value as biomarkers TCVI in chronic TBI, characterize the spatial distribution TCVI, relationships between each biomarker neuropsychological clinical assessments. Forty-two subjects (27 15 age- gender-matched healthy...
Stimulus-induced rhythmic, periodic, or ictal discharges (SIRPIDs) are a recently described form of epileptiform periodic evoked by arousal. Similar to other (e.g., pseudoperiodic lateralized discharges, generalized bilaterally independent discharges), SIRPIDs lie somewhere along an ictal-interictal continuum. To determine whether represent phenomenon reflected increased focal cerebral perfusion on single-photon emission computerized tomography, conversely interictal pattern, the authors...
Abstract The meninges serve as a functional barrier surrounding the brain, critical to immune response, and can be compromised following head trauma. Meningeal enhancement detected on contrast-enhanced MRI in patients presenting with acute traumatic brain injury, even when CT is negative. Following trauma, gadolinium-based contrast appears extravasate from vasculature, enhancing dura within minutes, later permeates subarachnoid space. aims of this study were characterize initial kinetics...
Serial MRI facilitates the in vivo analysis of intra- and intersubject evolution traumatic brain injury lesions. Despite availability MRI, natural history experimental focal contusion lesions controlled cortical impact (CCI) rat model has not been well described. We performed CCI on rats during acute to chronic stages cerebral investigate time course changes brain. Female Wistar underwent their left motor cortex with a flat tip driven by an electromagnetic piston. In was at 7 T serially over...
Older age consistently relates to a lesser ability fully recover from traumatic brain injury (TBI); however, there is limited data explicate the nature of age-related risks. This study was undertaken determine relationship on gene-activity following TBI, and how this biomarker changes in neuroimaging findings. A younger group (between ages 19-35 years), an older 60-89 years) were compared global within 48 hours then at follow-up 1-week. At each time-point gene-expression profiles, imaging...
Spontaneous mild ventriculomegaly (MVM) was previously reported in ∼43% of Wistar rats association with vascular anomalies without phenotypic manifestation. This traumatic brain injury (TBI) weight drop model study investigates whether MVM (n = 15) have different responses that could inadvertently complicate the interpretation imaging studies compared normal 15). Quantitative MRI, including diffusion tensor (DTI) and magnetization transfer (MTI), immunohistochemistry (IHC) analysis were used...
Objective The primary objective of this study was to track the incidence and progression traumatic microbleeds (TMBs) for up five years following brain injury (TBI).Methods Thirty patients with mild, moderate, or severe TBI received initial MRI within 48 h continued in a longitudinal years. findings assessed across year period. In addition TMBs, we noted presence other imaging including diffusion weighted (DWI) lesions, extra-axial intraventricular hemorrhage, hematoma, meningeal enhancement...