A5075790819- Traumatic Brain Injury Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Cardiac Arrest and Resuscitation
- Innovations in Medical Education
- Sleep and Wakefulness Research
- Sleep and related disorders
- Disaster Response and Management
- Resilience and Mental Health
- Health and Medical Research Impacts
- Medical Education and Admissions
- S100 Proteins and Annexins
- Posttraumatic Stress Disorder Research
- Occupational Health and Performance
- Simulation-Based Education in Healthcare
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Sleep and Work-Related Fatigue
- Vestibular and auditory disorders
- Advanced MRI Techniques and Applications
- Redox biology and oxidative stress
- Anesthesia and Sedative Agents
- Education and Military Integration
- Connexins and lens biology
- Effects of Radiation Exposure
- Coffee research and impacts
- Health, Environment, Cognitive Aging
Uniformed Services University of the Health Sciences
2012-2024
Walter Reed Army Institute of Research
2015-2020
Naval Medical Research Command
2017-2020
National Institute of Nursing Research
2017
United States Military Academy
2017
United States Army Medical Research and Development Command
2017
Abstract Neurological dysfunction after traumatic brain injury (TBI) is caused by both the primary and a secondary cascade of biochemical metabolic events. Since TBI can be variety mechanisms, numerous models have been developed to facilitate its study. The most prevalent are controlled cortical impact fluid percussion injury. Both typically use "sham" (craniotomy alone) animals as controls. However, sham operation objectively damaging, we hypothesized that craniotomy itself may cause unique...
The role of caffeine in enhancing performance has been studied for years, and there is no doubt that can be enhancing. Also, a wealth information allows an interesting distinction between physical cognitive performance. Most adults America consume moderate doses various forms on daily basis as typically found coffee, tea, soft drinks, dietary supplements, energy shots, chocolate, well over-the-counter pills gums. Although readily available widely consumed, when using it to enhance...
Emotional processing is particularly sensitive to sleep deprivation, but research on the topic has been limited and prior studies have generally evaluated only a circumscribed subset of emotion categories. Here, we effects one night deprivation subsequent recovery ability identify six most widely agreed upon basic categories (happiness, surprise, fear, sadness, disgust, anger). Healthy adults (29 males; 25 females) classified series 120 standard facial expressions that were computer morphed...
Combat military and civilian law enforcement personnel may be exposed to repetitive low-intensity blast events during training operations. Persons who use explosives gain entry (i.e., breach) into buildings are known as "breachers" or dynamic personnel. Breachers operate under the guidance of established safety protocols, but despite these precautions, breachers low-level throughout their careers frequently report performance deficits symptoms healthcare providers. Although little is about...
Injuries from exposure to explosions rose dramatically during the Iraq and Afghanistan wars, which motivated investigations of blast-related neurotrauma operational breaching. In this study, military "breachers" were exposed controlled, low-level blast a 10-day explosive breaching course. Using an omics approach, we assessed epigenetic, transcriptional, inflammatory profile changes in blood trainees, with varying levels lifetime exposure, along daily self-reported symptoms (with tinnitus,...
Abstract Motor and sensory deficits are common following traumatic brain injury (TBI). Although rodent models provide valuable insight into the biological functional outcomes of TBI, success translational research is critically dependent upon proper selection sensitive, reliable, reproducible assessments. Published literature includes various observational scales designed to evaluate post‐injury functionality; however, heterogeneity in TBI location, severity, symptomology can complicate...
Important challenges for the diagnosis and monitoring of mild traumatic brain injury (mTBI) include development plasma biomarkers assessing neurologic injury, pathogenesis, predicting vulnerability untoward outcomes. While several biomarker proteins have shown promise in this regard, used individually, these candidates lack adequate sensitivity and/or specificity making a definitive or identifying those at risk subsequent pathology. The objective study was to evaluate panel six recognized...
Closed-head concussive injury is one of the most common causes traumatic brain (TBI). Isolated concussions frequently produce acute neurological impairments, and individuals typically recover spontaneously within a short time frame. In contrast, injuries resulting from multiple can result in cumulative damage elevated risk developing chronic pathologies. Increased attention has focused on identification diagnostic markers that prognostically serve as indices health after injury, revealing...
Repeated exposure to low-level blast is a characteristic of few select occupations and there concern that such occupational exposures present risk for traumatic brain injury. These include specialized military law enforcement units employ controlled detonation explosive charges the purpose tactical entry into secured structures. The negative effects from based on rates operator self-reported headache, sleep disturbance, working memory impairment, other concussion-like symptoms. A challenge...
The Women in Combat Symposium was held at the Defense Health Headquarters April 29 to May 1, 2014, cohosted by Office of Assistant Secretary for Affairs and Consortium Military Performance. conference a call renew extend research investment policy commitment recognize operational scenarios, requirements, health priorities, combat-related injury exposures uniquely relevant performance well-being female Service members. participants worked groups identify knowledge capability gaps critical...
<h3>Objective:</h3> To explore gene expression after moderate blast exposure (vs baseline) and proteomic changes moderate- low-) exposure. <h3>Methods:</h3> Military personnel (N = 69) donated blood for quantification of protein level, peak pressure exposures were detected by helmet sensors before during a training program (10 days total). On day 7, some participants (n 29) sustained (mean 7.9 psi) matched to with no/low-blast the 40). PAXgene tubes collected from one site at baseline 10;...
Autoimmune profiling in rats revealed the antioxidant enzyme, peroxiredoxin 6 (PRDX6), as a target for autoantibodies evoked response to traumatic brain injury (TBI). Consistent with this proposal, immunohistochemical analysis of rat cerebral cortex demonstrated that PRDX6 is highly expressed perivascular space, presumably contained within astrocytic foot processes. Accordingly, an immunosorbent electrochemiluminescence assay was developed investigating human samples. found be measurable...
To investigate the effects of caffeine on psychomotor vigilance and sleepiness during sleep restriction following subsequent recovery sleep. Participants were N = 48 healthy good sleepers. All participants underwent five nights satiation (time-in-bed [TIB]: 10 hours), followed by (TIB: 5 three 8 hours) in a laboratory. Caffeine (200 mg) or placebo was administered form chewing gum at 08:00 am 12:00 pm each day phase. completed hourly 10-minute tests modified Maintenance Wakefulness Test...
Serial MRI facilitates the in vivo analysis of intra- and intersubject evolution traumatic brain injury lesions. Despite availability MRI, natural history experimental focal contusion lesions controlled cortical impact (CCI) rat model has not been well described. We performed CCI on rats during acute to chronic stages cerebral investigate time course changes brain. Female Wistar underwent their left motor cortex with a flat tip driven by an electromagnetic piston. In was at 7 T serially over...
Abstract Traumatic brain injury (TBI) is a serious health concern for civilians and military populations, blast‐induced TBI (bTBI) has become an increasing problem personnel over the past 10 years. To understand biological psychological effects of injuries to examine potential interventions that may help prevent, attenuate, treat bTBI, it valuable conduct controlled animal experiments. This unit discusses available paradigms model traumatic in animals, with emphasis on relevance these...
Abstract Military and law enforcement breachers are exposed to many low-level blasts during their training occupational experiences in which they detonate explosives force entry into secured structures. There is a concern that exposure these repetitive blast events career could result cumulative neurological effects. This study aimed determine concentrations of neurofilament light (NF-L), tau, amyloid-beta 42 (Aβ42) serum neuronal-derived extracellular vesicles (EVs) an experienced breacher...
Traumatic brain injury (TBI) pathophysiology can be attributed to either the immediate, primary physical injury, or delayed, secondary which begins minutes hours after initial and persist for several months longer. Because these cascades are delayed last a significant time period post-TBI, they research targets new therapeutics. To investigate changes in mitochondrial function both cortical impact site ipsilateral hippocampus of adult male rats 7 17 days controlled (CCI) were examined. State...
Mesenchymal stromal cells secrete a variety of anti-inflammatory factors and may provide regenerative medicine option for the treatment traumatic brain injury. The present study investigates efficacy multiple intravenous or intracardiac administrations rat mesenchymal human in female rats after controlled cortical impact by vivo MRI, neurobehavior, histopathology evaluation. Neither nor administration derived from either humans improved MRI measures lesion volume neurobehavioral outcome...
ABSTRACT Introduction Developing physicians as leaders has gained attention across the United States. Undergraduate medical education (UME) and graduate (GME) leader development programs have increased. During postgraduate years (PGY), graduates bring their leadership to bedside; however, associations between performance in school GME is largely unknown. It important find experiences that can assess may be useful predict future performance. The purpose of this study was determine if (1)...
ABSTRACT Introduction Leadership development is a cornerstone aspect of military medical education. Operation Bushmaster, field practicum (MFP) conducted by the USU, tests fourth-year students’ clinical skills and leadership acumen in an operational environment. No studies have examined perceptions their own during this MFP. Therefore, study explored from perspectives. Materials Methods Using qualitative phenomenological design, we analyzed reflection papers 166 students who participated...
Objectives To evaluate how blast exposure impacts peripheral biomarkersin military personnel enrolled in 10-day training.Methods On day 7, 21 experienced peak overpressure <2 pounds per square inch (psi); while 29 ≥5 psi. Blood samples were collected each to measure changes amyloid beta (Aβ), neurofilament light chain (NFL), and tau concentrations.Results Within 24 hours following psi, the psi group had lower Aβ42 (p = .004) NFL < .001) compared (9.35%) (22.01%) baseline. Twenty-four after...