A5103073009- Neuroinflammation and Neurodegeneration Mechanisms
- Blood groups and transfusion
- Biochemical effects in animals
- Immunodeficiency and Autoimmune Disorders
- Pain Mechanisms and Treatments
- Inflammatory mediators and NSAID effects
- Connexins and lens biology
- Adenosine and Purinergic Signaling
- Transplantation: Methods and Outcomes
- Lung Cancer Treatments and Mutations
- Cytokine Signaling Pathways and Interactions
- Lymphoma Diagnosis and Treatment
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Redox biology and oxidative stress
- Complement system in diseases
- S100 Proteins and Annexins
- Drug-Induced Adverse Reactions
- Renal Transplantation Outcomes and Treatments
- Chronic Lymphocytic Leukemia Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Vagus Nerve Stimulation Research
- Neuroscience and Neuropharmacology Research
- Osteoarthritis Treatment and Mechanisms
- Cardiac Arrest and Resuscitation
- Traumatic Brain Injury Research
University of Calgary
2015-2021
Uniformed Services University of the Health Sciences
2015
Canadian Blood Services
2014-2015
Center for Neuroscience and Regenerative Medicine
2015
A new therapeutic option for treating arthritis pain.
Important challenges for the diagnosis and monitoring of mild traumatic brain injury (mTBI) include development plasma biomarkers assessing neurologic injury, pathogenesis, predicting vulnerability untoward outcomes. While several biomarker proteins have shown promise in this regard, used individually, these candidates lack adequate sensitivity and/or specificity making a definitive or identifying those at risk subsequent pathology. The objective study was to evaluate panel six recognized...
Autoimmune profiling in rats revealed the antioxidant enzyme, peroxiredoxin 6 (PRDX6), as a target for autoantibodies evoked response to traumatic brain injury (TBI). Consistent with this proposal, immunohistochemical analysis of rat cerebral cortex demonstrated that PRDX6 is highly expressed perivascular space, presumably contained within astrocytic foot processes. Accordingly, an immunosorbent electrochemiluminescence assay was developed investigating human samples. found be measurable...
Increased afferent input resulting from painful injury augments the activity of central nociceptive circuits via both neuron-neuron and neuron-glia interactions. Microglia, resident immune cells nervous system (CNS), play a crucial role in pathogenesis chronic pain. This study provides framework for understanding how peripheral joint signals CNS to engage spinal microglial responses. During first week monosodium iodoacetate (MIA)-induced knee male rats, inflammatory neuropathic pain were...
Purpose: To evaluate the impact to cPRA in a waitlist population, if DQA, DPA and DPB donor typings, fully resolved serologic equivalents are included Canadian Calculator (CcPRA) or excluded (OPTN calculator-OcPRA). Methods: Single antigen (Ag) frequencies broad for DQ7,8,9(DQ3) DQ5,6(DQ1) not OcPRA were compared. using loci limited was compared waitlisted patients establish baseline population similarity. between calculators when included. Results: 818 prevalent patients’ (pts) (n=506 (62%)...