A5015046378- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- Osteoarthritis Treatment and Mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Rheumatoid Arthritis Research and Therapies
- Traumatic Brain Injury Research
- Bone and Joint Diseases
- Bone health and osteoporosis research
- Autoimmune and Inflammatory Disorders Research
- Medical Imaging Techniques and Applications
- Lower Extremity Biomechanics and Pathologies
- Bone health and treatments
- MRI in cancer diagnosis
- Knee injuries and reconstruction techniques
- Advancements in Photolithography Techniques
- Temporomandibular Joint Disorders
- High Altitude and Hypoxia
- Bone Metabolism and Diseases
- NMR spectroscopy and applications
- Advanced NMR Techniques and Applications
- Neuroscience of respiration and sleep
- Obstructive Sleep Apnea Research
- Functional Brain Connectivity Studies
- Musculoskeletal synovial abnormalities and treatments
- Cerebrospinal fluid and hydrocephalus
Uniformed Services University of the Health Sciences
2014-2025
Center for Neuroscience and Regenerative Medicine
2016-2022
Henry M. Jackson Foundation
2016-2022
Maryland Oncology Hematology
2019
Unifor
2018
Merck & Co., Inc., Rahway, NJ, USA (United States)
2009-2017
University of Pennsylvania
2013-2016
Children's Hospital of Philadelphia
2013-2016
Philadelphia University
2013-2016
United States Military Academy
2009-2013
To evaluate differences in white matter diffusion properties as a function of age healthy children and adolescents.Echo-planar diffusion-tensor magnetic resonance (MR) imaging was performed 33 subjects aged 5-18 years who were recruited from functional study normal language development. Results neurologic, psychologic, structural MR examinations within the range for all subjects. The trace apparent coefficient fractional anisotropy correlated by using Spearman rank correlation.Statistically...
A possible relationship between cognitive abilities and white matter structure as assessed by magnetic resonance diffusion tensor imaging (DTI) was investigated in the pediatric population. DTI performed on 47 normal children ages 5-18. Using a voxelwise analysis technique, fractional anisotropy (FA) mean diffusivity (MD) were tested for significant correlations with Wechsler full-scale IQ scores, subject age gender used covariates. Regions displaying positive of scores FA found bilaterally...
PURPOSE: To determine if age and early symptomatic degeneration alter the spatial dependency of cartilage T2. MATERIALS AND METHODS: In 25 asymptomatic volunteers six with symptoms patellar chondromalacia, quantitative T2 maps were obtained a multiecho, spin-echo magnetic resonance imaging sequence at 3.0 T. Spatial variation in was evaluated as function participant symptoms. RESULTS: All demonstrated continuous increase from radial zone to articular surface. population aged 46–60 years...
To determine the spatial variation of in vivo cartilage T2 young asymptomatic adults.Quantitative maps seven male adults and one volunteer with a history previous intraarticular chondroid fragments were calculated by using multiecho, spin-echo magnetic resonance imaging sequence at 3.0 T. The bilinearly interpolated to generate profiles across thickness cartilage.All volunteers demonstrated monotonic increase T2, which increased from 32 msec +/- 1 deep radial zone 48 transitional 67 2 outer...
Abstract Technical limitations imposed by resolution and B1 homogeneity have thus far limited quantitative in vivo T2 mapping of cartilage to the patella. The purpose this study is develop femoral/tibial joint assess regional variability knee. Quantitative knee was performed on 15 asymptomatic adults (age, 22–44) using a 3T MR scanner. There consistent pattern spatial variation with longer values near articular surface. greatest occurs patella, where increases from 45.3 ± 2.5 msec at...
Abstract Previous studies have found developmental differences between males and females in brain structure. During childhood adolescence, relative white matter volume increases faster boys than girls. Sex the development of microstructure were investigated a cohort normal children ages 5–18 cross‐sectional diffusion tensor imaging (DTI) study. Greater fractional anisotropy (FA) was shown associative regions (including frontal lobes), while greater FA girls splenium corpus callosum. mean...
The purpose of this study was to perform a quantitative evaluation the effect static magnetic field orientation on cartilage transverse (T2) relaxation time in intact living joint and determine magnitude magic angle vivo femoral cartilage.Quantitative T2 maps femoral-tibial were obtained eight asymptomatic male volunteers using 3-T magnet. Cartilage profiles (T2 vs normalized distance from subchondral bone) evaluated as function radial zone with applied (B(0)).At 0.3 bone, is 8.6% longer...
Purpose To analyze T2 maps of pelvic and thigh muscles in Duchenne muscular dystrophy (DMD), to identify the most severely affected muscle, correlate muscle with grade fatty infiltration at nonquantitative magnetic resonance (MR) imaging results clinical assessment. Materials Methods This prospective study was HIPAA compliant approved by institutional review board; written consent obtained from all participants' parents or guardians. Thirty-four boys DMD (mean age, 8.4 years) were evaluated...
The reduction of the apparent diffusion coefficient (ADC) water shortly after a focal ischemic insult is thought to reflect intracellular accumulation (cytotoxic edema) related high-energy metabolism failure and loss ion homeostasis. We attempted clarify whether varying ranges ADC measurements in brain tissue can be used differentiate between reversible irreversible lesions before reperfusion temporary ischemia model. induced 45 minutes 12 rats using middle cerebral artery suture occlusion...
All participants provided informed consent to participate in this study, which was approved by the institutional review board of Milton S. Hershey Medical Center. The purpose study determine feasibility cartilage T2 mapping evaluation response femoral and tibial running exercise. Quantitative magnetic resonance (MR) maps weight-bearing articular were obtained seven young healthy men before immediately after 30 minutes using a 3.0-T MR imager. There no statistically significant change...
To conduct a rigorous evaluation of the repeatability liver stiffness assessed by MR elastography (MRE) in healthy and hepatitis-C-infected subjects.A biopsy-correlated study using four-slice MRE was conducted five four HCV-infected subjects. Subjects were scanned twice on day 1 after 7-14 days. Each slice acquired during 14-s breath-hold with commercially available acquisition technique (MR-Touch, GE Healthcare). Results analyzed two independent analysts.The intraclass correlation...
Odanacatib, a cathepsin K inhibitor, increases spine and hip areal bone mineral density (BMD) in postmenopausal women with low BMD cortical thickness ovariectomized monkeys.The objective of the study was to examine impact odanacatib on trabecular compartments estimated strength at spine.This randomized, double-blind, 2-year trial.The conducted private or institutional practice.PARTICIPANTS included 214 BMD.The intervention 50 mg placebo weekly.Changes by dual-energy x-ray absorptiometry...
Abstract Traumatic microbleeds are small foci of hypointensity seen on T2*-weighted MRI in patients following head trauma that have previously been considered a marker axonal injury. The linear appearance and location some traumatic suggests vascular origin. aims this study were to: (i) identify characterize with acute brain injury; (ii) determine whether predict clinical outcome; (iii) describe the pathology underlying an index patient. Patients presenting to emergency department who...
Abstract Diffusion‐weighted, echo‐planar imaging (EPI) was used to map regional changes In the apparent diffusion coefficient (ADC) during experimental focal ischemia in rat brain following permanent middle cerebral arterial occlusion (MCAO). Sixteen 64 × diffusion‐weighted EPIs were acquired 32 s with successively increasing amplitudes of diffusion‐sensitive gradient pulses. A linear least‐squares regression algorithm fit 15 16 two‐dimensional matrices, on a pixel‐by‐pixel basis, solve for...
Abstract Fluorine‐19 inversion‐recovery, echo‐planar imaging (IR‐EPI) wais used in conjunction with a new PFC emulsion, perfluoro‐15‐crown‐5‐ether, to map the spatial distribution of oxygen tension murine liver, spleen and radiation induced fibrosarcoma (RIF‐1) tumors. Intravenously administered emulsions were allowed sequester spleen, tumor 3 7 days prior experiments. Seven, 64 × IR‐EPls acquired successively increasing inversion times (TI). A nonlinear least‐squares regression algorithm...
Abstract Objective Because the magnetic resonance imaging (MRI) transverse relaxation time (T2) of cartilage is sensitive to organization collagen fibers in cartilage, it may be a noninvasive image marker for senescent changes and early degeneration. The purpose this study was determine age‐dependent differences T2 values healthy asymptomatic women. Methods Quantitative maps patellar from 30 women ages 22–86 years were obtained using 3.0T MRI scanner. population stratified by age into 4...
Noninvasive detection of mild traumatic brain injury (mTBI) is important for evaluating acute through chronic effects head injuries, particularly after repetitive impacts. To better detect abnormalities from mTBI, we performed longitudinal studies (baseline, 3, 6, and 42 days) using magnetic resonance diffusion tensor imaging (DTI) kurtosis (DKI) in adult mice mTBI (r-mTBI; daily × 5) or sham procedure. This r-mTBI produced righting reflex delay was first characterized the corpus callosum to...
ABSTRACT The cathepsin K inhibitor odanacatib (ODN), currently in phase 3 development for postmenopausal osteoporosis, has a novel mechanism of action that reduces bone resorption while maintaining formation. In 2 studies, increased areal mineral density (aBMD) at the lumbar spine and total hip progressively over 5 years. To determine effects ODN on cortical trabecular estimate changes strength, we conducted randomized, double-blind, placebo-controlled trial, using both quantitative computed...
To determine the magnetic resonance (MR) imaging findings in knee early juvenile rheumatoid arthritis.MR (1.5 T) was performed more symptomatic 30 children with arthritis a symptom duration 1 year or less. Conventional, fast spin-echo, three-dimensional gradient-echo, and gadolinium-enhanced T1-weighted images were assessed. Two radiologists independently read images, third resolved disagreements. These compared radiographs 27 children.Mean maximal synovial thickness 4.8 mm +/- 2.4 (SD)....