A5067918450- Osteoarthritis Treatment and Mechanisms
- Bone health and osteoporosis research
- Bone and Joint Diseases
- Lower Extremity Biomechanics and Pathologies
- Knee injuries and reconstruction techniques
- Hip disorders and treatments
- Total Knee Arthroplasty Outcomes
- Musculoskeletal synovial abnormalities and treatments
- Medical Imaging Techniques and Applications
- Medical Imaging and Analysis
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Spine and Intervertebral Disc Pathology
- Advanced X-ray and CT Imaging
- Rheumatoid Arthritis Research and Therapies
- Orthopaedic implants and arthroplasty
- Hip and Femur Fractures
- Shoulder Injury and Treatment
- Musculoskeletal pain and rehabilitation
- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Bone health and treatments
- Orthopedic Infections and Treatments
- Cancer-related molecular mechanisms research
- Bone Metabolism and Diseases
University of California, San Francisco
2016-2025
University of California System
2011-2024
Berry (United States)
2015-2024
University of St. Francis
2005-2022
Laboratoire d’Imagerie Biomédicale
2022
Nordhausen University of Applied Sciences
2017
Deutsches Archäologisches Institut, Zentrale
2016
Technical University of Munich
2001-2012
Max Planck Institute for Extraterrestrial Physics
2004-2012
Klinikum rechts der Isar
2002-2012
Osteoporosis is becoming an increasingly important public health issue, and effective treatments to prevent fragility fractures are available. imaging of critical importance in identifying individuals at risk for who would require pharmacotherapy reduce fracture also monitoring response treatment. Dual x-ray absorptiometry currently the state-of-the-art technique measure bone mineral density diagnose osteoporosis according World Health Organization guidelines. Motivated by a 2000 National...
ABSTRACT The goal of this magnetic resonance (MR) imaging study was to quantify vertebral bone marrow fat content and composition in diabetic nondiabetic postmenopausal women with fragility fractures compare them nonfracture controls without type 2 diabetes mellitus. Sixty-nine (mean age 63 ± 5 years) were recruited. Thirty-six patients (47.8%) had spinal and/or peripheral fractures. Seventeen fracture diabetic. Thirty-three (52.2%) controls. Sixteen To composition, underwent MR spectroscopy...
Abstract The purpose of this study was to use high resolution (HR) magnetic resonance (MR) images the calcaneus investigate trabecular structure patients with and without osteoporotic hip fractures compare these techniques bone mineral density (BMD) in differentiating fracture nonfracture patients. Axial sagittal HR MR were obtained 50 females (23 postmenopausal 27 controls). A three-dimensional gradient–echo sequence used a slice thickness 500 μm plane 195 × μm. Texture analysis performed...
Pelvic and proximal femur insufficiency fractures are of increasing significance in our aging population, cross-sectional imaging is challenging. The aims this study were to compare the sensitivity CT MRI detecting fractures; analyze typical location, morphology, combinations thereof these morphology; associated clinical findings.MRI studies obtained at 1.5 T analyzed 145 patients with pelvic fractures. In 64 patients, multidetector (MDCT) findings compared. Imaging by two radiologists;...
To longitudinally evaluate cartilage matrix changes by using magnetic resonance (MR) imaging T1(ρ) (T1 relaxation time in rotating frame) and T2 quantification to study the relationship between meniscal damage degeneration anterior cruciate ligament (ACL)-reconstructed knees.This was an institutional review board-approved, HIPAA-compliant study. Informed consent obtained. Twelve patients with acute ACL injuries were imaged 3.0-T MR at baseline (after injury prior reconstruction) 1 year after...
Background Semiquantitative assessment of MRI plays a central role in musculoskeletal research; however, the clinical setting reports often tend to be subjective and qualitative. Grading schemes utilized research are not used because they extraordinarily time‐consuming unfeasible practice. Purpose To evaluate ability deep‐learning models detect stage severity meniscus patellofemoral cartilage lesions osteoarthritis anterior cruciate ligament (ACL) subjects. Study Type Retrospective study...
Abstract T 1ρ and 2 relaxation time constants have been proposed to probe biochemical changes in osteoarthritic cartilage. This study aimed evaluate the spatial correlation distribution of values Ten patients with osteoarthritis (OA) 10 controls were studied at 3T. The was investigated using Z ‐scores. variation patellar cartilage different layers. these measured texture analysis parameters based on gray‐level co‐occurrence matrices (GLCM). mean ‐scores for significantly higher OA vs. ( P...
The goals of this study were (i) to compare the prevalence focal knee abnormalities, mean cartilage T2 relaxation time, and spatial distribution magnetic resonance (MR) times between subjects with without risk factors for Osteoarthritis (OA), (ii) determine relationship MR parameters, age morphology as determined whole-organ imaging scores (WORMS) (iii) assess reproducibility WORMS scoring time measurements including grey level co-occurrence matrix (GLCM) texture parameters.Subjects OA (n =...
Abstract Purpose: To show the feasibility of assessing spatial distribution skeletal muscle adipose tissue using chemical shift‐based water/fat separation and to characterize differences in calf intermuscular (IMAT) compartmentalization patients with type 2 diabetes mellitus (T2DM) compared healthy age‐matched controls. Materials Methods: A approach a multiecho 3D spoiled gradient echo sequence was applied study 64 patients, including 35 controls 29 subjects T2DM. Masks were defined based on...
Background A multitask deep learning model might be useful in large epidemiologic studies wherein detailed structural assessment of osteoarthritis still relies on expert radiologists' readings. The potential such a clinical routine should investigated. Purpose To develop for grading radiographic hip features radiographs and compare its performance to that attending-level radiologists. Materials Methods This retrospective study analyzed joints seen weight-bearing anterior-posterior pelvic...
Purpose To test the hypothesis that artificial intelligence (AI) techniques can aid in identifying and assessing lesion severity cartilage, bone marrow, meniscus, anterior cruciate ligament (ACL) knee, improving overall MRI interreader agreement. Materials Methods This retrospective study was conducted on 1435 knee studies (n = 294 patients; mean age, 43 years ± 15 [standard deviation]; 153 women) collected within three previous (from 2011 to 2014). All were acquired using...