A5075674884- Bone health and osteoporosis research
- Bone health and treatments
- Bone and Joint Diseases
- Medical Imaging Techniques and Applications
- Bone Metabolism and Diseases
- Radiomics and Machine Learning in Medical Imaging
- Hip and Femur Fractures
- Parathyroid Disorders and Treatments
- Bone fractures and treatments
- Advanced X-ray and CT Imaging
- Orthopaedic implants and arthroplasty
- Connective tissue disorders research
- Hip disorders and treatments
- Medical Imaging and Pathology Studies
- Medical Imaging and Analysis
- Orthopedic Infections and Treatments
- Bone Tumor Diagnosis and Treatments
- Organ Transplantation Techniques and Outcomes
- Vitamin D Research Studies
- Advanced Neuroimaging Techniques and Applications
- Fetal and Pediatric Neurological Disorders
- Congenital Diaphragmatic Hernia Studies
- Liver Disease and Transplantation
- Transplantation: Methods and Outcomes
- Congenital Heart Disease Studies
Vienna General Hospital
2021-2025
Medical University of Vienna
2016-2025
Klinik und Poliklinik für Nuklearmedizin
2015-2024
University of Vienna
2010-2023
University of California, San Francisco
2011-2016
University of California System
2011-2013
Innsbruck Medical University
2007-2010
Abstract The primary goal of this study was to assess peripheral bone microarchitecture and strength in postmenopausal women with type 2 diabetes fragility fractures (DMFx) compare them diabetics without (DM). Secondary goals were differences nondiabetic (Fx) (Co), DM Co women. Eighty (mean age 61.3 ± 5.7 years) recruited into these four groups (DMFx, DM, Fx, Co; n = 20 per group). Participants underwent dual-energy X-ray absorptiometry (DXA) high-resolution quantitative computed tomography...
ABSTRACT The goal of this magnetic resonance (MR) imaging study was to quantify vertebral bone marrow fat content and composition in diabetic nondiabetic postmenopausal women with fragility fractures compare them nonfracture controls without type 2 diabetes mellitus. Sixty-nine (mean age 63 ± 5 years) were recruited. Thirty-six patients (47.8%) had spinal and/or peripheral fractures. Seventeen fracture diabetic. Thirty-three (52.2%) controls. Sixteen To composition, underwent MR spectroscopy...
Sclerostin is a soluble inhibitor of osteoblast function. downregulated by the parathyroid hormone (PTH). Here, it was investigated whether sclerostin levels are influenced intact (i) PTH and associated with bone turnover, microarchitecture mass in dialysis patients. Seventy-six haemodialysis patients 45 healthy controls were included this cross-sectional study. Sclerostin, Dickkopf-1 (DKK-1), (iPTH), vitamin D markers turnover analysed. A subset 37 had measurements mineral density (BMD)...
Standard DXA measurements, including Fracture Risk Assessment Tool (FRAX) scores, have shown limitations in assessing fracture risk Type 2 Diabetes (T2D), underscoring the need for novel biomarkers and suggesting that other pathomechanisms may drive diabetic bone fragility. MicroRNAs (miRNAs) are secreted into circulation from cells of various tissues proportional to local disease severity were recently found be crucial homeostasis T2D. Here, we studied, if which circulating miRNAs or...
Abstract High-resolution peripheral quantitative computed tomography (HR-pQCT) has recently been introduced as a clinical research tool for in vivo assessment of bone quality. The utility this technology to address important skeletal health questions requires translation standardized multicenter data pools. Our goal was evaluate the feasibility pooling HR-pQCT imaging trials. Reproducibility experiments were performed using structure and composition-realistic phantoms constructed from...
Dialysis patients are at high risk for low-trauma bone fracture. Bone density measurements using dual-energy x-ray absorptiometry (DXA) do not reliably differentiate between with and without fractures. The aim of this study was to identify differences in microarchitecture a history fracture high-resolution peripheral quantitative computed tomography (HR-pQCT).
To evaluate the feasibility and reproducibility of superb microvascular imaging (SMI) neonatal brain to describe normal features. We performed transcranial ultrasound with SMI in 19 healthy term-born neonates. was done according a structured examination protocol, using two linear 18 MHz 14 transducers. Superficial deep scans were acquired coronal sagittal planes, left right superior frontal gyri as anatomical landmarks. All views imaged by monochrome colour evaluated respect visibility...
Abstract Background Liver transplantation is the state-of-the-art curative treatment for end-stage liver disease. Imaging a key element in detection of postoperative complications. So far, limited data available regarding best radiologic approach to monitor children after transplantation. Objective To harmonize imaging pediatric transplantation, European Society Pediatric Radiology Abdominal Taskforce initiated survey addressing current status including pre-, intra-, and phases. This paper...
Abstract A huge number of inbred mouse strains with different bone properties have become available for musculoskeletal research. C57Bl/6J and C3H/HeOuJ mice show a significant difference in their characteristics. Nevertheless, there is lack knowledge on the molecular basis these strain differences. The aim this study to determine gene expression selected regulators expressed marrow as well microstructure mice. Bone were investigated 20-week-old female Total RNA was extracted from tibia...
The aim of our study was to assess the attitudes towards AI and teleradiology their current usage in pediatric radiology within German-speaking countries.From March May 2023, we conducted an anonymous online survey among members Society for Pediatric Radiologists (GPR) Swiss Radiology (SGPR) via SurveyMonkey platform. consisted 25 items with rating scales open-ended responses.Out 418 society members, 36 completed questionnaire (8.6%). Teleradiology (50% fully agree, 27.8% partly agree)...
Background/objectives: This study prospectively evaluated clinical outcomes and osseous consolidation in patients with symptomatic scaphoid non-union treated avascular bone grafting percutaneous screw fixation. Two imaging methods, MDCT (multi-detector computed tomography) HR-pQCT (high-resolution peripheric quantitative computer tomography), were employed to assess healing. Methods: In Vienna, eight consecutive nine non-unions underwent revision surgery. Clinical measured using DASH PRWE...
Abstract Male idiopathic osteoporosis (MIO) is a metabolic bone disease that characterized by low mass, microstructural alterations, and increased fracture risk in otherwise healthy men. Although the detailed pathophysiology of MIO has yet to be clarified, evidence increasingly suggests an osteoblastic defect as underlying cause. In this study we tested hypothesis expression profile certain or osteoblast-related genes (ie, WNT10B, RUNX2, Osterix, Osteocalcin, SOST, RANKL, OPG) different...
To assess lesion detection and artifact size reduction of a multiacquisition variable-resonance image combination, slice encoding for metal correction (MAVRIC-SEMAC) hybrid sequence (MAVRIC-SL) compared to standard sequences at 1.5T 3T in porcine knee specimens with hardware.Artificial cartilage bone lesions defined were created the proximity titanium steel screws 2.5 mm diameter 12 imaged magnetic resonance imaging (MRI) MAVRIC-SL PD short T1 inversion recovery (STIR), fast spin echo (FSE)...
ABSTRACT The spectrum of therapeutic options and the amount clinical trials for male osteoporosis (mOP) is lower than those postmenopausal osteoporosis. Therefore, we examined effects 24 months ibandronate (IBN) treatment (3 mg/3 mL intravenously every 3 months) on bone material quality in 19 subjects with mOP within an open-label, single-center, prospective phase III study (Eudract number 2006-006692-20). Patients (median age [25th, 75th percentiles] 53.0 [44.5; 57.0] years) were included...