A5085794534- Bone health and osteoporosis research
- Bone health and treatments
- Bone Metabolism and Diseases
- Bone and Joint Diseases
- Connective tissue disorders research
- Hip and Femur Fractures
- Bone fractures and treatments
- Spondyloarthritis Studies and Treatments
- Vitamin D Research Studies
- Shoulder Injury and Treatment
- Rheumatoid Arthritis Research and Therapies
- Shoulder and Clavicle Injuries
- MicroRNA in disease regulation
- Liver Disease Diagnosis and Treatment
- Hip disorders and treatments
- Bone and Dental Protein Studies
- Bariatric Surgery and Outcomes
- Pelvic and Acetabular Injuries
- Muscle metabolism and nutrition
- Diet and metabolism studies
- Liver Diseases and Immunity
- Hematological disorders and diagnostics
- Vitamin K Research Studies
- Psoriasis: Treatment and Pathogenesis
- Liver Disease and Transplantation
Medical University of Vienna
2015-2024
Barmherzige Schwestern Krankenhaus Wien
2015-2023
St Vincent Medical Center
2008-2022
Vienna General Hospital
2015-2022
Vinforce
2010-2022
St Vincent Hospital
2008-2022
Ordensklinikum Linz Barmherzige Schwestern
2008-2021
Universitätszahnklinik Wien
2019-2021
Applied Optimization (United States)
2020
Karl Landsteiner Society
2015
Context: Established bone turnover markers do not reflect fracture risk in idiopathic male and premenopausal osteoporosis the role of microRNAs (miRNAs) these patients is currently unclear. miRNAs are a class small non-coding RNAs that regulate gene expression tissue homeostasis. They considered new endocrine regulators with promising potential as biomarkers. Objective: Evaluation circulating miRNA signatures female subjects postmenopausal osteoporotic low-traumatic fractures. Design,...
ABSTRACT Laparoscopic Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) are common effective methods to treat severe obesity, but these procedures can adversely influence bone metabolism areal mineral density (aBMD). This was a prospective 24-month single-center interventional two-arm study in 220 women similarly aged men (median age 40.7 years) with body mass index (BMI) >38 kg/m2 after RYGB SG procedures. Patients were randomized into: 1) an intervention group receiving:...
The role of sclerostin as a key regulator bone formation remains unknown after Roux-en-Y gastric bypass (RYGB) or laparoscopic sleeve gastrectomy (SG).The study objectives were evaluation and Dickkopf-1 (DKK-1) serum levels surgery correlations with turnover markers (P1NP, CTX), parathyroid hormone (iPTH) areal mineral density (BMD), changes at total body, lumbar spine hip.This was prospective observational single-center two-arm in premenopausal women acute adipositas over 24...
Psoriatic arthritis (PsA) is a chronic inflammatory disease characterized by periarticular bone loss and new formation. Current data regarding systemic mineral density (BMD) in PsA are conflicting. The aim of this study was to evaluate microstructure volumetric BMD (vBMD) patients with psoriasis. We performed HR-pQCT scans at the ultradistal radius 50 patients, 30 psoriasis 70 healthy, age- sex-related controls assessing trabecular volume (BV/TV), number (Tb.N), inhomogeneity network,...
The assessment of bone quality and the prediction fracture risk in idiopathic osteoporosis (IOP) are complex prospects as mineral density (BMD) turnover markers (BTM) do not indicate fracture-risk. MicroRNAs (miRNAs) promising new biomarkers for diseases, but current understanding biological information contained variability miRNAs is limited. Here, we investigated association between serum-levels 19 miRNA to microstructure histomorphometry based upon biopsies µCT (9.3 μm) scans from 36...
Abstract During teriparatide (TPTD) treatment, high levels of bone formation are accompanied by an increase in resorption. The aim this work was to test if coadministration raloxifene (RAL) or alendronate (ALN) following 9 months ongoing TPTD therapy would reopen the anabolic window, thereby exerting additional benefit on mineral density (BMD). Postmenopausal women (n = 125) with severe osteoporosis treatment for were randomized into three open-label groups a further months: ALN (70 mg/week)...
Abstract Nine month teriparatide (TPTD) monotherapy followed by co-administration of raloxifene (RAL) or alendronate (ALN) for another nine 9 months resulted in incremental bone mineral density (BMD) increase. The aim this study was to investigate the effects continued antiresorptive treatments 12 extension phase. Postmenopausal women (n = 125) with severe osteoporosis on ongoing TPTD treatment were randomized into three open-label groups months: ALN (70 mg/week, n 41), RAL (60 mg/d, 37)...
In the present study, we investigated bone geometry, microstructure, and volumetric mineral density (vBMD) in a cohort of patients with nonradiographic axial spondyloarthritis (nr-axSpA) order to define early changes occurring (axSpA) potential factors for deterioration microstructure.Patients axSpA (n = 107) healthy control subjects 50) similar age sex were assessed geometric, volumetric, microstructural parameters using high-resolution peripheral quantitative computed tomography (HR-pQCT)...
Fragility fractures are a frequent and costly event. In Austria, 92,835 fragility occurred in patients aged ≥ 50 years 2018, accruing direct costs of > 157 million €. Due to demographic aging, the number their associated expected increase even further.Fragility frequently with long hospital stays, loss independence, increased need for care elderly, consequences often leading premature death. The aim this study was estimate healthcare Austria 2018.The in-patient cases relevant ICD-10...
The aim of this study was to report the effects denosumab on radius cortical and trabecular bone density, mass, strength, wrist fracture incidence in FREEDOM (Fracture REduction Evaluation Denosumab Osteoporosis every 6 Months) study.In study, postmenopausal women with osteoporosis (N = 7,808) received placebo or 60 mg months for 36 months. Radius mineral density (BMD), content, strength (polar moment inertia) were evaluated two prespecified substudies using dual-energy x-ray absorptiometry...
Abstract Male idiopathic osteoporosis (MIO) is a metabolic bone disease that characterized by low mass, microstructural alterations, and increased fracture risk in otherwise healthy men. Although the detailed pathophysiology of MIO has yet to be clarified, evidence increasingly suggests an osteoblastic defect as underlying cause. In this study we tested hypothesis expression profile certain or osteoblast-related genes (ie, WNT10B, RUNX2, Osterix, Osteocalcin, SOST, RANKL, OPG) different...
Liver cirrhosis leads to bone loss. To date, information on quality (three-dimensional microarchitecture) and, thus, strength is scarce. We observed decreased at both assessed sites, independent of disease severity. Therefore, all patients should undergo early-stage screening for osteoporosis. Recent studies found low mineral density in cirrhosis, but data microstructure are This study weight-bearing and non-weight-bearing bones with healthy controls. The primary objective was evaluate...
Background: Bone mineral density at the humeral head is reduced in patients with chronic rotator cuff tears. loss associated repair failure after reconstruction. Bisphosphonates (eg, zoledronic acid) increase bone density. Hypothesis: Zoledronic acid improves of and biomechanical properties enthesis reconstruction tears rats. Study Design: Controlled laboratory study. Methods: A total 32 male Sprague-Dawley rats underwent unilateral (left) supraspinatus tenotomy delayed transosseous 3 weeks....
ABSTRACT The spectrum of therapeutic options and the amount clinical trials for male osteoporosis (mOP) is lower than those postmenopausal osteoporosis. Therefore, we examined effects 24 months ibandronate (IBN) treatment (3 mg/3 mL intravenously every 3 months) on bone material quality in 19 subjects with mOP within an open-label, single-center, prospective phase III study (Eudract number 2006-006692-20). Patients (median age [25th, 75th percentiles] 53.0 [44.5; 57.0] years) were included...
Background and Aims: To investigate the macro- microstructural changes of bone in patients with inflammatory bowel disease [IBD] to define factors associated loss IBD. Methods: A total 148 subjects, 59 Crohn's [CD], 39 ulcerative colitis [UC], 50 healthy controls were assessed for geometric, volumetric properties using high-resolution peripheral quantitative computed tomography. In addition, demographic disease-specific characteristics IBD recorded. Results: comparable age, sex, body mass...
Abstract Context MicroRNAs (miRNAs)—short, single-stranded, noncoding RNAs—regulate several biological processes, including bone metabolism. Objective We investigated circulating miRNAs as promising biomarkers for treatment monitoring in women with postmenopausal osteoporosis on denosumab (DMAB) therapy. Methods In this prospective, observational, single-center study, 21 treated DMAB were included a longitudinal follow-up of 2 years. Next-generation sequencing (NGS) was performed to screen...
Background: Characteristics of chronic rotator cuff tears include continuous loss tendon structure as well elasticity, followed by a high failure rate after surgical reconstruction. Several studies have already shown the beneficial effect extracorporeal shockwave therapy (ESWT) on tissue regeneration in pathologies. Hypothesis: ESWT improves biomechanical properties functional shoulder outcomes reconstruction rodents. Study Design: Controlled laboratory study. Methods: After detachment and 3...