A5062541403- Vitamin D Research Studies
- Bone health and osteoporosis research
- Mesenchymal stem cell research
- Bone health and treatments
- Fatty Acid Research and Health
- Vitamin C and Antioxidants Research
- COVID-19 Clinical Research Studies
- Wound Healing and Treatments
- Peroxisome Proliferator-Activated Receptors
- Antioxidant Activity and Oxidative Stress
- Long-Term Effects of COVID-19
- Retinoids in leukemia and cellular processes
- Nuts composition and effects
- Bone Metabolism and Diseases
- Adipose Tissue and Metabolism
- Adipokines, Inflammation, and Metabolic Diseases
- Parathyroid Disorders and Treatments
- Pharmacological Effects and Toxicity Studies
- MicroRNA in disease regulation
- Bone and Joint Diseases
- Cancer, Hypoxia, and Metabolism
- Endometriosis Research and Treatment
- Cancer Cells and Metastasis
- Medical Imaging and Pathology Studies
- Diabetic Foot Ulcer Assessment and Management
Instituto Maimónides de Investigación Biomédica de Córdoba
2015-2024
Hospital Universitario Reina Sofía
2015-2024
University of Córdoba
2015-2024
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable
2017-2024
Instituto de Salud Carlos III
2022-2023
Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
2023
Fundación Progreso y Salud
2020-2021
Biomedical Research Institute
2018
Sociedad Española de Endocrinología y Nutrición
2017
Centro de Excelencia en Procesos y Productos de Córdoba
2017
Abstract Context COVID-19 is a major health problem because of saturation intensive care units (ICU) and mortality. Vitamin D has emerged as potential treatment able to reduce the disease severity. Objective This work aims elucidate effect 25(OH)D3 (calcifediol) on COVID-19–related outcomes. Methods observational cohort study was conducted from March May 2020, among patients admitted wards Hospital del Mar, Barcelona, Spain. A total 930 with were included; 92 excluded previous calcifediol...
ABSTRACT Vitamin D has shown to play a role in multiple diseases due its skeletal and extraskeletal actions. Furthermore, vitamin deficiency become worldwide health issue. Few supplementation guidelines mention calcifediol treatment, despite being the direct precursor of calcitriol biomarker status. This 1-year, phase III–IV, double-blind, randomized, controlled, multicenter clinical trial assessed efficacy safety 0.266 mg soft capsules D–deficient postmenopausal women, compared...
Adipogenesis is a physiological process required for fat‐tissue development, mainly involved in regulating the organism energetic‐state. Abnormal distribution‐changes and dysfunctions such tissue are associated to different pathologies. Adipocytes generated from progenitor cells, via complex differentiating not yet well understood. Therefore, we investigated differential mRNA miRNA expression patterns of human mesenchymal stromal‐cells (MSC) induced differentiate into adipocytes by next...
Phloretin (a flavonoid abundant in apple), has antioxidant, anti-inflammatory, and glucose-transporter inhibitory properties. Thus, it interesting pharmacological nutraceutical potential. Bone-marrow mesenchymal stem cells (MSC) have high differentiation capacity, being essential for maintaining homeostasis regenerative capacity the organism. Yet, they preferentially differentiate into adipocytes instead of osteoblasts with aging. This a negative impact on bone turnover, remodeling,...
Medical treatment of coronavirus 19 disease (COVID-19) is a therapeutic challenge. The available data strongly suggest that calcifediol may reduce the severity COVID-19, and corticosteroids are choice worldwide for severe COVID-19. Both have very similar action profile, their combined use in patients modify contribution each administered compound. Objective: To evaluate how with and/or medical practice modified need ICU admission, death, or poor prognosis hospitalized COVID-19 during first...
Transcriptomic analysis in human MSC differentiated into adipocytes presence of oleuropein, identifies possible pathways responsible for its antiadipogenic effect.