A5007287776- Bone health and osteoporosis research
- Bone health and treatments
- COVID-19 and healthcare impacts
- Estrogen and related hormone effects
- Rheumatoid Arthritis Research and Therapies
- Long-Term Effects of COVID-19
- Bone and Joint Diseases
- Global Cancer Incidence and Screening
- COVID-19 Clinical Research Studies
- COVID-19 and Mental Health
- Chronic Disease Management Strategies
- Healthcare Systems and Reforms
- Vitamin D Research Studies
- Hip and Femur Fractures
- Cancer Diagnosis and Treatment
- Healthcare cost, quality, practices
- Medical Coding and Health Information
- HIV-related health complications and treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Health Systems, Economic Evaluations, Quality of Life
- Migration, Health and Trauma
- Clinical practice guidelines implementation
- Health disparities and outcomes
- Viral Infections and Immunology Research
- Economic and Financial Impacts of Cancer
University of Oxford
2020-2025
Nuffield Orthopaedic Centre
2020-2025
NIHR Oxford Musculoskeletal Biomedical Research Centre
2024
Hospital del Mar Research Institute
2019-2023
Universitat Autònoma de Barcelona
2020-2023
Municipal Institute for Medical Research
2016-2021
Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable
2016-2021
Instituto de Salud Carlos III
2017-2020
Hospital Del Mar
2018-2020
Escuela Nacional de Sanidad
2020
Abstract Context COVID-19 is a major health problem because of saturation intensive care units (ICU) and mortality. Vitamin D has emerged as potential treatment able to reduce the disease severity. Objective This work aims elucidate effect 25(OH)D3 (calcifediol) on COVID-19–related outcomes. Methods observational cohort study was conducted from March May 2020, among patients admitted wards Hospital del Mar, Barcelona, Spain. A total 930 with were included; 92 excluded previous calcifediol...
Abstract Intersectional social determinants including ethnicity are vital in health research. We curated a population-wide data resource of self-identified from over 60 million individuals England primary care, linking it to hospital records. assessed terms completeness, consistency, and granularity found one ten do not have information recorded care. By records, were completed for 94% individuals. reconciling SNOMED-CT concepts census-level categories into consistent hierarchy, we organised...
Introduction The COVID-19 pandemic had collateral effects on many health systems. Cancer screening and diagnostic tests were postponed, resulting in delays diagnosis treatment. This study assessed the impact of screening, diagnostics incidence breast, colorectal, lung, prostate cancer; whether rates returned to pre-pandemic levels by December, 2021. Methods is a cohort electronic records from United Kingdom (UK) primary care Clinical Practice Research Datalink (CPRD) GOLD database. included...
Abstract Heat waves are a major public health challenge, yet the link between heat-related illness (HRI) and regional climate geography is underexplored. We examined HRI excess sun exposure incidence rates (IR) [95% confidence interval (CI) per 100,000 person-years], their correlation with maximum temperatures across 9 US climatic zones 33,603,572 individuals were followed from 2017 to 2022. observed 10,652 diagnosis (median age: 49 years, 62.3% male). Seasonal peaks occurred during summer:...
ABSTRACT Aromatase inhibitors have been associated with accelerated bone loss and an increased risk of osteoporotic fractures. Currently, bisphosphonates are recommended to reduce fracture in these patients. The aim this study is evaluate the breast cancer patients receiving aromatase inhibitors, compared tamoxifen users, assess effectiveness oral reducing risk. We performed observational cohort up 10 years follow-up. Data were extracted from primary care records a population database. Women...
To explore clustering of comorbidities among patients with a new diagnosis OA and estimate the 10-year mortality risk for each identified cluster.This is population-based cohort study individuals first incident hip, knee, ankle/foot, wrist/hand or 'unspecified' site between 2006 2020, using SIDIAP (a primary care database representative Catalonia, Spain). At time diagnosis, conditions associated in literature that were found ≥1% (n = 35) fitted into two cluster algorithms, k-means latent...
Background: The COVID-19 pandemic affected cancer screening, diagnosis and treatments. Many surgeries were substituted with bridging therapies during the initial lockdown, yet consideration of treatment side effects their management was not a priority. Objectives: To examine how changing social restrictions imposed by incidence trends endocrine prescriptions in newly diagnosed (incident) breast prostate patients and, secondarily, treatment-related outcomes (including bisphosphonate...
ABSTRACT Objectives This study aimed to assess the impact of COVID-19 lockdown on screening and diagnosis breast, colorectal, lung, prostate cancer. The also investigated whether rates returned pre-pandemic levels by December 2021. Design Cohort study. Setting Electronic health records from UK primary care Clinical Practice Research Datalink (CPRD) GOLD database. Participants included individuals registered with CPRD between January 2017 2021, at least 365 days prior observation. Main...
Dear Preprints with the Lancet Readers, We removed this preprint due to concerns about description of research in paper. This led us initiate an investigation into study.Following conclusion study by National Centre Biomedical Research on Frailty and Healthy Aging (CIBERFES), Spain, report concluded that: 1) In elaboration manuscript correspondence authors Journal, there was a series mistakes made qualification its description; 2) At all times good practices for clinical were carefully...
<title>Abstract</title> Prior evidence has suggested the multisystem symptomatic manifestations of post-acute COVID-19 condition (PCC). Here we conducted a network cluster analysis 24 WHO proposed symptoms to identify potential latent subclasses PCC. Individuals with positive test or diagnosed SARS-CoV-2 after 09/2020 and at least one symptom within ≥ 90 365 days following infection were included. Sub-analyses among people 3 different symptoms. Summary characteristics provided for each...
Abstract Importance Drug shortages leave affected patients in a vulnerable position. Objective To describe incidence and prevalence of use for medicines with suggested at least one European country, as announced by the Medicines Agency, to characterise users these drugs including indication use, duration dosage. Design We performed descriptive cohort study from 2010 up 2024 network databases which have mapped their data Observational Medical Outcomes Partnership (OMOP) Common Data Model...
Background: Tamoxifen (TAM) and aromatase inhibitor (AI) therapies have been associated with increased risk of thromboembolic cardiovascular events, respectively, in addition to other side effects. This study analysed the these events overall survival (OS) benefit breast cancer patients treated AI, compared TAM-treated patients, a large population-based cohort. Methods: observational cohort included women diagnosed TAM or AI. Data were extracted from primary care records population database...
The availability of anti-osteoporosis medications with rapid onset and high potency requires tools to identify patients at imminent fracture risk (IFR). There are few that predict a patient's IFR. We aimed develop validate for recent initiating oral bisphosphonate therapy. Models two separate cohorts, those incident fragility (IFx) prescription (OBP), were developed in primary care records from Spain (SIDIAP database), UK (Clinical Practice Research Datalink GOLD), Denmark (Danish Health...
ABSTRACT The objective of this work was to estimate the incidence rate cardiovascular disease (CVD) events (myocardial infarction, stroke, or CVD death) at 1 year among three cohorts patients high risk fracture (osteoporosis, previous fracture, and anti-osteoporosis medication) identify key factors in these cohorts. To do so, prospective cohort study used data from Clinical Practice Research Datalink, a primary care database United Kingdom. Major adverse (MACE, composite outcome for...
Abstract Background The mechanisms behind ART-induced bone changes in HIV-infected patients are poorly known. We aimed to analyse inflammatory and markers HIV after tenofovir disoproxil fumarate initiation, the associations with strength parameters. Methods HIV-positive participants starting fumarate-based ART underwent dual-energy X-ray absorptiometry (QDR 4500 SL®, Hologic, Waltham, MA, USA) for mineral density (BMD), a microindentation test (OsteoProbe®, Active Life Scientific, Santa...
Abstract Background Bone mineral density (BMD) decreases with ART initiation a tenofovir disoproxil fumarate-containing regimen, although bone tissue quality increases. The impact of dolutegravir (DTG)/abacavir (ABC)/lamivudine (3TC)-based on health parameters is not clear. Objectives To study the DTG/ABC/3TC-based therapy in ART-naive individuals HIV after 48 weeks treatment. Methods An observational, prospective and analytical treatment-naive patients undergoing regimen at week follow-up....
ABSTRACT The DKK1 gene encodes an extracellular inhibitor of the Wnt pathway with important role in bone tissue development, homeostasis, and different critical aspects biology. Several BMD genome‐wide association studies (GWASs) have consistently found SNPs genomic region. For these reasons, it is to assess functionality coding regulatory variants gene. Here, we studied putative variants, previously associated by others ourselves, also six missense present general population. Using a...