A5027322215- Bone Metabolism and Diseases
- Bone health and osteoporosis research
- Estrogen and related hormone effects
- Bone health and treatments
- Ovarian function and disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Menopause: Health Impacts and Treatments
- Reproductive Health and Technologies
- Reproductive Biology and Fertility
- Antioxidant Activity and Oxidative Stress
- TGF-β signaling in diseases
- Immune Cell Function and Interaction
- Vitamin D Research Studies
- Reproductive System and Pregnancy
- Bone and Joint Diseases
- Amino Acid Enzymes and Metabolism
- MicroRNA in disease regulation
- Global Health Workforce Issues
- Diet and metabolism studies
- Inflammatory mediators and NSAID effects
- Nutrition and Health in Aging
- Circular RNAs in diseases
- Metabolism and Genetic Disorders
- Nutritional Studies and Diet
- Neuroendocrine regulation and behavior
Universitat de València
2015-2024
INCLIVA Health Research Institute
2014-2023
Biomedical Research Institute
2021
Menéndez Pelayo International University
2015-2016
Hospital Del Mar
2016
Hospital del Mar Research Institute
2016
Universitat Autònoma de Barcelona
2016
Municipal Institute for Medical Research
2016
Instituto Valenciano de la Edificación
2014
Hospital Clínico Universitario de Valencia
2003-2011
Estradiol (E 2 ) acts on the endothelium to promote vasodilatation through release of several compounds, including prostanoids, which are products arachidonic acid metabolism. Among these, prostacyclin (PGI2) and thromboxane A2 (TXA2) exert opposite effects vascular tone. The role different estrogen receptors (ERs) in PGI2/TXA2 balance, however, has not been fully elucidated. Our study sought uncover whether E enhances basal production PGI2 or TXA2 cultured human umbilical vein endothelial...
Objective/Hypothesis This study examined correlations between surgical recommendations based on either drug‐induced sleep endoscopy (DISE) or common awake examination methods in patients with obstructive apnea syndrome (OSAS). Study Design Prospective, blinded, clinical trial at a university hospital. Methods An otorhinolaryngologist designed plans for OSAS after examination, lateral cephalometry, the Müller maneuver, and Friedman staging. A second blinded to previous made DISE. third person...
Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide (NO) synthase, is a novel cardiovascular risk factor produced by endothelial cells. ADMA levels are mainly regulated the activity dimethylaminohydrolases (DDAH). Endothelial release increased in presence oxidized LDL cholesterol (oxLDL), whereas estrogens stimulate NO production cells increasing both expression and synthase reducing levels. Thus, aim present study was to evaluate estradiol effects on DDAH/ADMA/NO...
Vascular effects of estradiol are being investigated because there controversies among clinical and experimental studies. DNA microarrays were used to investigate global gene expression patterns in cultured human umbilical vein endothelial cells (HUVEC) exposed 1 nmol/L for 24 hours. When compared control, 187 genes identified as differentially expressed with 1.9-fold change threshold. Supervised principal component analysis hierarchical cluster revealed the differences between control...
This study aims to analyze, in mice, the long-term effects of delayed fatherhood on postnatal development, spontaneous motor activity, and learning capacity offspring. Hybrid parental-generation (F(0)) males, at age 12, 70, 100, 120 wk, were individually housed with a randomly selected 12-wk-old hybrid female. The resulting first-generation (F(1)) offspring tested for several developmental behavioral variables. Cumulative percentage F(1) pups that attained immediate righting 120-wk group was...
Genes explaining the susceptibility to osteoporosis have not been fully elucidated. Our objective was explore association of polymorphisms capturing common variations lipoprotein receptor-related protein (LRP) 5 and 6 genes, encoding two Wnt receptors, with femoral neck bone mineral density (BMD) osteoporotic fractures spine hip.Cross-sectional, case-control, replication genetic study.Thirty-nine tagging functional single nucleotide (SNPs) were analyzed in a group 1043 postmenopausal women...
ABSTRACT Gamma interferon (IFN-γ) and the cellular responses induced by it are essential for controlling mycobacterial infections. Most patients bearing an IFN-γ receptor ligand-binding chain (IFN-γR1) deficiency present gross mutations that truncate protein prevent its expression, giving rise to severe infections and, frequently, a fatal outcome. In this report new mutation affects IFN-γR1 domain in Spanish patient with disseminated infection multifocal osteomyelitis is characterized. The...
The molecular mechanisms of the vascular effects phytoestrogens are poorly studied. Prostacyclin is a potent vasodilator synthesized by two isoforms cyclooxygenase (COX) in endothelium. This study examine phytoestrogens, isoflavones genistein and daidzein, on prostacyclin production cultured human umbilical vein endothelial cells (HUVECs) possible role not only estrogen receptors but also both COX isoforms. significantly increased release time- dose-dependent (0.01-1 μM) manner, being higher...
This study aims to analyze, in mice, the long-term effects of delayed fatherhood on reproductive fitness and longevity offspring. Hybrid parental-generation (F(0)) males, at age 12, 70, 100, 120 wk, were individually housed with a randomly selected 12-wk-old hybrid female. The first-generation (F(1)) females was tested from 25 wk until end their life. In F(1) testing period ranged 52 death. Breeding 120-wk group displayed interbirth intervals longer than 12-, 70-, 100-wk groups. Furthermore,...