A5082707461- HIV-related health complications and treatments
- Bone and Joint Diseases
- HIV/AIDS drug development and treatment
- COVID-19 Clinical Research Studies
- HIV Research and Treatment
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- HIV/AIDS Research and Interventions
- Respiratory Support and Mechanisms
- MicroRNA in disease regulation
- Poxvirus research and outbreaks
- HIV/AIDS oral health manifestations
- Lymphoma Diagnosis and Treatment
- Influenza Virus Research Studies
- COVID-19 and Mental Health
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Herpesvirus Infections and Treatments
- Dermatological and COVID-19 studies
Hospital Del Mar
2020-2025
Universitat Autònoma de Barcelona
2024
Hospital del Mar Research Institute
2022
Universitat Pompeu Fabra
2022
ObjectivesThe objective of this study was to estimate the association between tocilizumab or corticosteroids and risk intubation death in patients with coronavirus disease 19 (COVID-19) a hyperinflammatory state according clinical laboratory parameters.MethodsA cohort performed 60 Spanish hospitals including 778 COVID-19 data indicative state. Treatment mainly tocilizumab, an intermediate-high dose (IHDC), pulse (PDC), combination therapy, no treatment. Primary outcome death; follow-up 21...
ABSTRACT Background Passive immunotherapy with convalescent plasma (CP) is a potential treatment for COVID-19 which evidence from controlled clinical trials lacking. Methods We conducted multi-center, randomized trial in patients hospitalized COVID-19. All received standard of care treatment, including off-label use marketed medicines, and were 1:1 to receive one dose (250-300 mL) CP donors IgG anti-SARS-CoV-2. The primary endpoint was the proportion categories 5, 6 or 7 ordinal scale at day...
Background The impact of tenofovir disoproxil fumarate (TDF) antiretroviral (ART) regimens on bone health has been characterized mostly by mineral density (BMD), but recently also quality (BQ). aim this pilot study is to assess the changes in BMD and BQ after switch from TDF alafenamide (TAF) ART. Methods HIV individuals receiving TDF-based ART were randomized Bictegravir-TAF-Emtricitabine or remain same regimen. At baseline 24-weeks randomization, participants underwent (BMD) DXA assessment...
This real-world study compared the safety and effectiveness of Dolutegravir/lamivudine (D/L) Bictegravir/Emtricitabine/Tenefovir alafenamide (B/F/T) switch therapy regimens for people living with HIV (PLWH).The retrospective conducted from April 2019 to November 2022, included PLWH < 50 copies/mL HIV-RNA prior recruitment who initiated either D/L or B/F/T switching therapy. The primary objective was evaluate treatment discontinuation rates; virologic outcomes were also evaluated.690...
Abstract People living with human immunodeficiency virus (HIV) are the individuals most affected by current Monkeypox outbreak that was first announced in May 2022. Here we report Pan‐pox‐specific T‐cell responses a cohort of HIV‐1‐infected after receiving nonreplicative, attenuated smallpox vaccine JYNNEOS from Bavarian Nordic. Intradermal (i.d.) and subcutaneous (s.c.) vaccination safe without major side effects. Dose‐sparing i.d. superior to s.c. promoted polyfunctionality, expression...
Abstract Purpose To design a randomized clinical trial to assess the efficacy and safety of favipiravir in patients with COVID-19 disease pneumonia. Methods A randomized, double blind, placebo-controlled pneumonia was conducted three Spanish sites. Randomization 1:1 or placebo (in both groups added Standard Care) performed treat The primary endpoint “time improvement,” measured as an improvement for ≥ two categories on 7-point WHO ordinal scale up 28 days' time frame. Results Forty-four were...
Abstract Introduction People with HIV (PWH) poor immune response despite adequate antiretroviral treatment (ART) are susceptible to non-AIDS-related health issues. This study seeks evaluate bone quality in immunological nonresponders (INRs) comparison those proper (IRs) using vivo microindentation quantify quality, addition conventional mineral density (BMD) evaluations. Methods A cross-sectional was conducted at Hospital del Mar Barcelona from January 2019 June 2023. Participants were...
To compare clinical characteristics, outcomes, and resource consumption of patients with coronavirus disease 2019 (COVID-19) seasonal influenza requiring supplemental oxygen.Retrospective cohort study conducted at a tertiary-care hospital. Patients admitted because between 2017 2019, or COVID-19 March May 2020 oxygen were compared. Primary outcome: 30-day mortality. Secondary outcomes: 90-day mortality hospitalization costs. Attempted sample size to detect an 11% difference in was 187 per...
Abstract Objective The HIV infection is a chronic disease that causes neurocognitive impairment (NI) and has been related with early development of frailty. We aimed to study the main risk factors for disorders frailty in older adults. Materials methods Cross-sectional 40 individuals than 65 years under antiretroviral therapy Hospital del Mar (Barcelona) recruited between November 2019 October 2020. Data obtained through clinical scores blood sample evaluate NI analyzed non-parametric tests...
Abstract Background Bone mineral density (BMD) decreases with ART initiation a tenofovir disoproxil fumarate-containing regimen, although bone tissue quality increases. The impact of dolutegravir (DTG)/abacavir (ABC)/lamivudine (3TC)-based on health parameters is not clear. Objectives To study the DTG/ABC/3TC-based therapy in ART-naive individuals HIV after 48 weeks treatment. Methods An observational, prospective and analytical treatment-naive patients undergoing regimen at week follow-up....
Introduction. Long-term non-progressors (LTNPs) are HIV-infected individuals (HIV+) whose viral replication is controlled. However, these experience complications associated with HIV, among them, bone remodeling impairment. This study aims to perform a comprehensive health assessment and its association the inflammatory status of HIV+ LTNPs. A cross-sectional was conducted comparing strength components (bone mineral density tissue quality) between age-, sex-, comorbidities-matched groups...
Background: HIV infection produces a chronic inflammation which leads to early aging of people linving with HIV. The causes this persistent remain be unveil. Changes in microRNAs (miRNAs) expression the context may contribute different inflammatory response. Even though antiretroviral treatments (ART) have significantly increased patient survival, an underlying persist leading HIV-related comorbidities.\Objectives: To study differential circulating miRNAs treatment-naïve individuals compared...