A5059832232- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- HIV/AIDS drug development and treatment
- Long-Term Effects of COVID-19
- HIV Research and Treatment
- Clostridium difficile and Clostridium perfringens research
- Antibiotic Resistance in Bacteria
- Microscopic Colitis
- HIV/AIDS Research and Interventions
- Antimicrobial Resistance in Staphylococcus
- Hepatitis B Virus Studies
- Hepatitis C virus research
- Pneumonia and Respiratory Infections
- Antibiotics Pharmacokinetics and Efficacy
- Bacterial Infections and Vaccines
- Nosocomial Infections in ICU
- Tuberculosis Research and Epidemiology
- Urinary Tract Infections Management
- Helicobacter pylori-related gastroenterology studies
- Antibiotic Use and Resistance
- Fungal Infections and Studies
- Bacterial Identification and Susceptibility Testing
- COVID-19 and healthcare impacts
- HIV-related health complications and treatments
- Respiratory viral infections research
Hospital Universitario La Paz
2014-2024
Hospital La Paz Institute for Health Research
2021-2024
Instituto de Salud Carlos III
2001-2024
Centro de Investigación Biomédica en Red
2022-2024
Centre for Biomedical Network Research on Rare Diseases
2022-2024
Instituto de Investigación Biomédica de Salamanca
2024
Centro de Investigación Biomédica en Red de Cáncer
2024
Universidad Autónoma de Madrid
2021
Universidad Alfonso X el Sabio
2017
Universidad Autónoma de Ciudad Juárez
2016
ObjectivesThe objective of this study was to estimate the association between tocilizumab or corticosteroids and risk intubation death in patients with coronavirus disease 19 (COVID-19) a hyperinflammatory state according clinical laboratory parameters.MethodsA cohort performed 60 Spanish hospitals including 778 COVID-19 data indicative state. Treatment mainly tocilizumab, an intermediate-high dose (IHDC), pulse (PDC), combination therapy, no treatment. Primary outcome death; follow-up 21...
Abstract Background Baricitinib has shown efficacy in hospitalized patients with COVID-19, but no placebo-controlled trials have focused specifically on severe/critical COVID, including vaccinated participants. Methods Bari-SolidAct is a phase-3, multicentre, randomised, double-blind, trial, enrolling participants from June 3, 2021 to March 7, 2022, stopped prematurely for external evidence. Patients COVID-19 were randomised 4 mg once daily or placebo, added standard of care. The primary...
Invasive pulmonary aspergillosis (IPA) is a complication of respiratory bacterial and viral infections such as coronavirus disease 2019 (COVID-19).In University Hospital La Paz (Madrid, Spain), we reviewed the clinical demographic characteristics 10 patients with positive severe acute syndrome 2 (SARS-CoV-2) PCR Aspergillus spp. isolate in samples. We also recovered results galactomannan tests serum and/or bronchoalveolar lavage (BAL) samples.Eight male two female from 51 to 76 years were...
Treatment of hepatitis B virus (HBV) with lamivudine may not completely suppress viral replication and often fails as a result resistance. Tenofovir is new HIV inhibitor further activity against HBV, which was explored in 12 HBV/HIV-co-infected patients detectable levels serum HBV-DNA, despite receiving lamivudine-containing antiretroviral regimen. Lamivudine-resistance mutations were found HBV from seven patients. HBV-DNA dropped median 3.78 logs baseline to 24 weeks. very effective at...
Background Human metapneumovirus (HMPV) has an important etiological role in acute lower respiratory infections children under five years. Our objectives were to estimate the relative contribution of HMPV hospitalization with infection, define clinical and epidemiological features single multiple infections, compare syncytial virus (HRSV), rhinovirus (HRV), adenovirus human bocavirus same population. Methods findings A prospective study performed on all less than 14 years age a tract disease...
Introduction: The concurrency of both, acute stroke and myocardial infarction in normal conditions, outside the pandemic is rare. Coagulopathy has been associated with inflammatory phase coronavirus disease (COVID-19) might be involved this concurrency. Cases Report: We describe 2 patients previous mild or no symptoms COVID-19, admitted for recent/simultaneous whom admission polymerase chain reaction was negative but serologic testing diagnosed COVID-19. In these patients, concurrent could...
Abstract Ventriculitis is a complication of meningitis (community-acquired or nosocomial) other central nervous system (CNS) infections such as brain abscess. They are associated with different spectrum microorganisms, from resistant gram-negative bacilli to staphylococci, that can lead serious illness high mortality. Difficult-to-treat resistance (DTR) may increase 20% deaths respective susceptible isolates the same bacteria. We present first report clinical cured case DTR Pseudomonas...
The immune suppression caused by HIV infection accelerates the course of liver disease chronic hepatitis B virus (HBV) infection. We assessed outcome HIV/HBV-coinfected patients exposed to highly active antiretroviral therapy (HAART) including anti-HBV drugs. Baseline and follow-up plasma HBVDNA HIV-RNA levels, HBV serological markers, CD4 counts were longitudinally evaluated in all HBsAg(+) individuals with on regular at an urban reference clinic. Out 79 carriers identified, 39 (50%)...
Bezlotoxumab is marketed for the prevention of recurrent Clostridioides difficile infection (rCDI). Its high cost could be determining its prescription to a different population than that represented in clinical trials. The objective study was verify effectiveness and safety bezlotoxumab preventing rCDI investigate factors related failure real world. A retrospective, multicentre cohort patients treated with Spain conducted. We compared characteristics those pivotal MODIFY assessed recurrence...
The SARS-CoV-2 pandemic might have increased the risks of healthcare-associated infections (HAIs); however, several studies HAI such as urinary tract (UTIs) and catheter-associated (CAUTIs) shown contradictory results. aim this study is to assess clinical features UTIs bacterial isolates from urine samples hospitalized COVID-19 patients. We conducted a retrospective observational including 87 patients with admitted our centre. Bacterial presented were 87: 9 (10.3%) community-acquired...
Background: Lopinavir/ritonavir (Kaletra) is the latest available protease inhibitor (PI). It has shown greater potency than former PIs in phase II/III trials, either naive or PI-experienced patients being for nonnucleoside reverse transcriptase inhibitors (NNRTIs). Method: We analyzed first 138 recruited during expanded access program an HIV/AIDS reference center. Only who had significant past exposure to all three different antiretroviral drug families and were failing their current...
Background. Because most infections caused by carbapenemase-producing Enterobacteriaceae (CPE) begin during hospitalization, there are limited data about community-onset (CO) CPE. Our aim is to describe the frequency of CO CPE as well clinical features bloodstream (CO-BSIs). Methods. This study includes retrospective case series in a tertiary hospital from January 2010 July 2014. Any sample with positive culture for that had been ordered primary care doctors or at emergency room (ER) were...
Both fidaxomicin and bezlotoxumab (used in combination with an antibiotic against Clostridioides difficile) achieve reductions recurrence rates of C. difficile infection (CDI). However, the two strategies have never been compared.Data from retrospective cohorts 'real-life' use a standard anti-C. were used to compare both strategies. Since not identical, we propensity score analysis.Three hundred patients included: 244 cohort 78 cohort. A history renal failure or immunosuppression was more...
ABSTRACT Epstein‐Barr virus (EBV) is a herpesvirus capable of establishing lifelong latent infections, leading to wide spectrum diseases. It can affect multiple organs, including the gastrointestinal tract, typically through lymphoproliferative syndromes or gastric cancer, while acute disease rare and poorly understood. Two cases EBV‐induced colitis in kidney transplant recipients were described. Additionally, scoping review literature was conducted identify all reported EBV infection...
Background Linezolid has good penetration to the meninges and could be an alternative for treatment of Staphylococcus aureus meningitis. We assessed efficacy safety linezolid therapy this infection.Methods Retrospective multicenter cohort study 26 adults treated with linezolid, derived from a 350 cases S. meningitis diagnosed at 11 university hospitals in Spain (1981-2015).Results There were 15 males (58%) mean age was 47.3 years. Meningitis postoperative 21 (81%) patients. The infection...