A5079611387- Mathematical Biology Tumor Growth
- Gene Regulatory Network Analysis
- Helicobacter pylori-related gastroenterology studies
- Antibiotic Resistance in Bacteria
- Angiogenesis and VEGF in Cancer
- Evolution and Genetic Dynamics
- Cancer Cells and Metastasis
- Magnetic confinement fusion research
- stochastic dynamics and bifurcation
- Epigenetics and DNA Methylation
- Microtubule and mitosis dynamics
- Ecosystem dynamics and resilience
- Mathematical and Theoretical Epidemiology and Ecology Models
- Fusion materials and technologies
- Antibiotics Pharmacokinetics and Efficacy
- Cancer, Hypoxia, and Metabolism
- Cellular Mechanics and Interactions
- Veterinary medicine and infectious diseases
- Superconducting Materials and Applications
- Antimicrobial Resistance in Staphylococcus
- Advanced Thermodynamics and Statistical Mechanics
- Microfluidic and Bio-sensing Technologies
- Bioinformatics and Genomic Networks
- Pluripotent Stem Cells Research
- Cancer Genomics and Diagnostics
Institució Catalana de Recerca i Estudis Avançats
2016-2025
Universitat Autònoma de Barcelona
2016-2025
Centre de Recerca Matemàtica
2015-2025
CEA Cadarache
2009-2023
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
2009-2023
London Institute for Mathematical Sciences
2008-2023
Basque Center for Applied Mathematics
2010-2023
Institute for Integrative Systems Biology
2023
Barcelona Graduate School of Mathematics
2016-2022
Hospital Universitario de La Princesa
1998-2018
We present a physiologically structured lattice model for vascular tumor growth which accounts blood flow and structural adaptation of the vasculature, transport oxygen, interaction between cancerous normal tissue, cell division, apoptosis, endothelial factor release, coupling these processes. Simulations are used to investigate effects nutrient heterogeneity, invasion emergent laws.
We investigate a three-dimensional multiscale model of vascular tumour growth, which couples blood flow, angiogenesis, remodelling, nutrient/growth factor transport, movement of, and interactions between, normal cells, nutrient-dependent cell cycle dynamics within each cell. In particular, we determine how the domain size, aspect ratio initial network influence tumour's growth its long-time composition. establish whether it is possible to extrapolate simulation results obtained for small...
When fighting cancer, knowledge on metabolism has always been important. Today, it matters more than ever. The restricted cataloging of cancer genomes is quite unlikely to achieve the task curing unless integrated into metabolic networks that respond and influence constantly evolving stem cell (CSC) cellular states. Once genomic era carcinogenesis had pushed 1920s Otto Warburg's hypothesis obscurity for decades, most recent studies begin support a new developing paradigm, in which molecular...
The scratch assay is an in vitro technique used to assess the contribution of molecular and cellular mechanisms cell migration. can also be evaluate therapeutic compounds before clinical use. Current quantification methods assays deal poorly with irregular cell-free areas crooked leading edges which are features typically present experimental data. We introduce a new migration method, called ‘monolayer edge velocimetry’, that permits analysis low-quality data better statistical...
Energy metabolism plasticity enables stemness programs during the reprogramming of somatic cells to an induced pluripotent stem cell (iPSC) state. This relationship may introduce a new era in understanding Warburg's theory on metabolic origin cancer at level (CSCs). Here, we used Yamanaka's technology attempt create stable CSC research lines which dissect transcriptional control mTOR—the master switch cellular catabolism and anabolism—in CSC-like states. The rare colonies with iPSC-like...
Abstract For the past several years, JET scientific programme (Pamela et al 2007 Fusion Eng. Des . 82 590) has been engaged in a multi-campaign effort, including experiments D, H and T, leading up to 2020 first with 50%/50% D–T mixtures since 1997 ever plasmas ITER mix of plasma-facing component materials. this purpose, concerted physics technology was launched view prepare campaign (DTE2). This paper addresses key elements developed by directly contributing preparation. intense preparation...
Abstract WEST is an MA class superconducting, actively cooled, full tungsten (W) tokamak, designed to operate in long pulses up 1000 s. In support of ITER operation and DEMO conceptual activities, key missions are: (i) qualification high heat flux plasma-facing components integrating both technological physics aspects relevant particle exhaust conditions, particularly for the monoblocks foreseen divertor; (ii) integrated steady-state at confinement, with a focus on power issues. During phase...
AIM: To investigate which factors predict outcome of elderly patients on discharge and at 6 months. METHODS: A prospective study in an acute geriatric ward. Within 48 h admission, were assessed for social factors, problems, admission diagnoses, medication, function mental ability. Outcome measures mortality, length stay, institutionalization, readmissions attendance accident emergency within RESULTS: 353 studied, with a mean age 81.8 years. Logistic regression analyses showed that variables...
We develop an off-lattice, agent-based model to describe vasculogenesis, the de novo formation of blood vessels from endothelial progenitor cells during development. The that comprise our vessel network are viewed as linearly elastic spheres move in response forces they experience. distinguish two types cells: elements contained within and tip located at ends vessels. Tip mechanical caused by interactions with neighbouring local tissue environment, chemotactic a persistence force which...
We introduce a hybrid two-dimensional multiscale model of angiogenesis, the process by which endothelial cells (ECs) migrate from pre-existing vascular bed in response to local environmental cues and cell-cell interactions, create new network. Recent experimental studies have highlighted central role cell rearrangements formation angiogenic networks. Our accounts for this phenomenon via heterogeneous ECs their microenvironment. These rearrangements, turn, dynamically remodel environment. The...
SOX2 is a core pluripotency-associated transcription factor causally related to cancer initiation, aggressiveness, and drug resistance by driving the self-renewal seeding capacity of stem cells (CSC).Here, we tested ability clinically proven inhibitor lysine-specific demethylase 1 (LSD1/KDM1A) iadademstat (ORY-100) target SOX2-driven CSC in breast cancer.Iadademstat blocked CSC-driven mammosphere formation cell lines that are dependent on expression maintain their phenotype.Iadademstat...
Significance Oxygen heterogeneity in solid tumors is recognized as a limiting factor for therapeutic efficacy. This arises from the abnormal tumor vascular structure. We investigate role that anomalies red blood cell transport plays establishing oxygen tissue. introduce metric to characterize vasculature (mean vessel length-to-diameter ratio, <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" overflow="scroll"> <mml:mi>λ</mml:mi> </mml:math> ) and demonstrate how it predicts...
The behavior of nonlinear systems near critical transitions has significant implications for stability, transients, and resilience in complex systems. Transient times, <a:math xmlns:a="http://www.w3.org/1998/Math/MathML"><a:mi>τ</a:mi></a:math>, become extremely long phase (or bifurcations) a phenomenon known as slowing down, are observed electronic circuits, circuit quantum electrodynamics, ecosystems, gene regulatory networks. Critical down typically follows universal laws the form <b:math...
Abstract A one-two punch sequential regimen of senescence-inducing agents followed by senolytic drugs has emerged as a novel therapeutic strategy in cancer. Unfortunately, cancer cells undergoing therapy-induced senescence (TIS) vary widely their sensitivity to senotherapeutics, and companion diagnostics predict the response TIS specific drug are lacking. Here, we hypothesized that ability BH3 profiling assay functionally measure mitochondrial priming state—the proximity apoptotic...
The maintenance of epigenetic landscapes (EL) requires the precise regulation chromatin-modifying enzymes (ChME). Competition for ChME can lead to degradation ELs, triggering large-scale changes in cell fate information contained EL. Predicting impending tipping points (ETP) by identifying early warning signals (EWS) may help anticipate onset identity loss during aging and cancer. We have developed a general mathematical framework that incorporates different connectivity patterns generated...