A5071731223- Health Systems, Economic Evaluations, Quality of Life
- Smoking Behavior and Cessation
- Advanced Causal Inference Techniques
- Health Policy Implementation Science
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Nicotinic Acetylcholine Receptors Study
- Air Quality and Health Impacts
- Behavioral Health and Interventions
- Cancer Risks and Factors
- Pharmaceutical Economics and Policy
- Pharmacovigilance and Adverse Drug Reactions
- Neuroscience of respiration and sleep
- Cannabis and Cannabinoid Research
- Radiomics and Machine Learning in Medical Imaging
- Long-Term Effects of COVID-19
- Innovation Policy and R&D
- Economic and Financial Impacts of Cancer
- Cancer Genomics and Diagnostics
- Gestational Diabetes Research and Management
- Cardiovascular Health and Risk Factors
- Biomedical Ethics and Regulation
- Healthcare Systems and Reforms
- Pharmaceutical industry and healthcare
- Breastfeeding Practices and Influences
- Biosimilars and Bioanalytical Methods
National Institute for Health and Care Excellence
2023-2024
University of Nottingham
2018-2021
Rigshospitalet
2020
Real-world evidence (RWE) in health technology assessment (HTA) holds significant potential for informing healthcare decision-making. A multistakeholder workshop was organised by the European Health Data and Evidence Network (EHDEN) GetReal Institute to explore status, challenges, opportunities incorporating RWE into HTA, with a focus on learning from regulatory initiatives such as Medicines Agency (EMA) Analysis Real World Interrogation (DARWIN EU
Abstract Background Assessing benefits and harms of health interventions is resource-intensive often requires feasibility pilot trials followed by adequately powered randomised clinical trials. Data from are used to inform the design sample size When a trial conducted, results may be disregarded in terms harms. Methods We describe using data Trial Sequential Analysis software estimate required for one or more investigating behavioural smoking cessation intervention. show how new, planned can...
Abstract Importance Drug shortages leave affected patients in a vulnerable position. Objective To describe incidence and prevalence of use for medicines with suggested at least one European country, as announced by the Medicines Agency, to characterise users these drugs including indication use, duration dosage. Design We performed descriptive cohort study from 2010 up 2024 network databases which have mapped their data Observational Medical Outcomes Partnership (OMOP) Common Data Model...
Abstract Background and Aims Due to concerns about increased exposure nicotine, pregnant women using nicotine replacement therapy (NRT) stop smoking are usually advised NRT if they relapse smoking. This study investigated whether this is justified. We compared changes in saliva cotinine from baseline 2 weeks post‐target quit date smokers who relapsed continued use their patches having been assigned or placebo. Design Setting Controlled pre–post design stratified by intervention condition the...
Although English Stop Smoking Services routinely offer dual nicotine replacement therapy (NRT) to help pregnant women quit smoking, little is known about how and tobacco smoke exposures following this compare with that from smoking. We compared, in when smoking after being offered NRT, saliva cotinine exhaled carbon monoxide (CO) concentrations numbers of daily cigarettes smoked.Secondary analysis data three sequential, observational, mixed-methods cohort studies conducted as part the...
Introduction There is an increasing number of policy and guidance documents on the use acceptability real-world evidence (RWE) to support regulatory health technology assessment (HTA) decision-making. The Innovative Health Initiative Integration Heterogeneous Data Evidence towards Regulatory HTA Acceptance (IDERHA) partnership undertaking a global landscape review these understand where there consensus divergence, further development needed. Methods A literature search MEDLINE Embase...
Background Smoking is a major international public health problem. Aim To determine effects of concurrent smoking and nicotine replacement therapy (NRT) use on reported heaviness smoking, (cotinine) body fluid, exhaled air carbon monoxide (CO) concentrations. Method Systematic review meta-analysis randomised controlled trials (RCTs) that test interventions permitting NRT comparing, within participants, outcomes when with those using concurrently. Results In total, 29 studies were included in...
Abstract Background: Assessing benefits and harms of health interventions is resource-intensive often requires feasibility pilot trials followed by adequately powered randomised clinical trials. Data from are used to inform the design sample size When a trial conducted, results may be disregarded in terms harms. Methods: We describe using data Trial Sequential Analysis software estimate required for one or more investigating behavioural smoking cessation intervention. show how new, planned...
Abstract Background Assessing benefits and harms of health interventions is resource-intensive often requires feasibility pilot trials followed by adequately powered randomised clinical trials. Data from are used to inform the design sample size When a trial conducted, results may be disregarded in terms harms. Methods We describe using data Trial Sequential Analysis program estimate required for one or more investigating behavioural smoking cessation intervention. show how new, planned can...
Abstract Background Assessing benefits and harms of health interventions is resource-intensive often requires feasibility pilot trials followed by adequately powered randomised clinical trials. Data from are used to inform the design sample size When a trial conducted, results may be disregarded in terms harms.MethodsWe describe using data Trial Sequential Analysis software estimate required for one or more investigating behavioural smoking cessation intervention. We show how new, planned...