A5011319147- Smoking Behavior and Cessation
- Behavioral Health and Interventions
- Air Quality and Health Impacts
- Health Literacy and Information Accessibility
- Obesity, Physical Activity, Diet
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cancer-related gene regulation
- Peroxisome Proliferator-Activated Receptors
- Epigenetics and DNA Methylation
- Digital Mental Health Interventions
- American History and Culture
- Palliative Care and End-of-Life Issues
- Geriatric Care and Nursing Homes
- Political Economy and Marxism
- Health, Environment, Cognitive Aging
- Interprofessional Education and Collaboration
- Chemokine receptors and signaling
- Whipple's Disease and Interleukins
- Neuroscience of respiration and sleep
- Nicotinic Acetylcholine Receptors Study
- Anesthesia and Pain Management
- Mental Health and Patient Involvement
- American Sports and Literature
- Health Policy Implementation Science
- Intestinal and Peritoneal Adhesions
University of Nottingham
2013-2025
Aberdeen Royal Infirmary
2024
University of Glasgow
1900-2015
Hannah Research Foundation
2002-2003
Western Infirmary
1900
The authors describe a rare case of 46-year-old woman, presenting with 1-year history wasting disease and widespread mediastinal lymphadenopathy on imaging. patient had pulmonary hypertension diagnosed 7 years prior been treated macitentan (an endothelin receptor antagonist) sildenafil. Following an admission to the authors’ centre severe anaemia workup for suspected haematological malignancy, duodenal biopsy confirmed diagnosis Whipple’s disease. Interestingly, did not report cardinal...
Increased life expectancy and the accompanying prevalence of chronic conditions have led to focus delivery health care migrating from hospital into people's homes. While previous studies investigated integration particular types medical devices home, it was our intention describe how are integrated lives older people. Adopting a qualitative study design, 12 people, who used in took part in-depth, semi structured interviews. In 7 interviews participants their partners were interviewed...
Smoking during pregnancy is a leading cause of negative and perinatal outcomes. While UK guidelines recommend nicotine replacement therapy (NRT) for smoking cessation pregnancy, adherence to NRT generally low may partially explain why appears less effective in compared non-pregnant smokers. This study aimed identify describe factors associated with from health professional’s perspective. Two focus groups one expert group were conducted 26 professionals involved antenatal stop services the...
Introduction Reducing smoking during pregnancy is a public health priority. Nicotine replacement therapy (NRT) offered routinely to pregnant women who smoke in the United Kingdom. However, evidence of treatment efficacy this population weak, most likely due poor adherence. Guided by Necessity‐Concerns Framework, we conducted qualitative study better understand women’s perceived needs and concerns regarding NRT use, with consideration combination NRT. Methods Semi‐structured interviews were...
Reducing smoking rates in pregnancy continues to be a public health priority. Given recent UK government policy change resulting The National Health Service (NHS) making significant new contribution cessation support England, addition that of Local Authorities (LA), an up-to-date assessment national offered pregnant women is needed. LA Stop Smoking (SSS) managers and representatives from maternity services NHS Trusts were invited participate online survey autumn 2020. Topics included service...
Improving adherence to nicotine replacement therapy (NRT) in pregnancy may result higher smoking cessation rates. Informed by the Necessities and Concerns Framework, we developed an intervention targeting NRT adherence. To evaluate this, derived necessities concerns questionnaire (NiP-NCQ), which measures perceived need for about potential consequences.Here describe development content validation of NiP-NCQ. From qualitative work, identified potentially modifiable determinants classed these...
Nicotine replacement therapy (NRT) helps people stop smoking. Monitoring treatment adherence is important as poor to NRT limits its effectiveness. As e-cigarettes contain nicotine, their use ('vaping') likely affect both and We wished measure NRT, investigate relationships between vaping smoking so we developed 'NicUse', a smartphone App linked cloud database for collecting data relevant adherence. report user-acceptability validity among pregnant by comparing heaviness of reported NicUse...
Many countries recommend Nicotine Replacement Therapy (NRT) for smoking cessation in pregnancy. Preclinical studies of nicotine exposure to pregnant mammals could indicate how may adversely affect the developing fetus. As a first step towards summarising this literature, we undertook systematic scoping review determine number and nature offspring outcomes studied.
Background Few studies have investigated how to best measure adherence smoking cessation medications, but continuous usage measures are recommended. Objective In this first study of its kind, we compared methods for measuring nicotine replacement therapy (NRT) among pregnant women, investigating the completeness and validity data collected from daily assessments using a smartphone app versus retrospective questionnaires. Methods Women aged ≥16 years who were smokers <25 weeks offered...
Many countries, including the UK, recommend nicotine replacement therapy (NRT) for smoking cessation during pregnancy. However, adherence to NRT is generally low, lapse or relapse common and using reduce harm from number of cigarettes smoked only advocated in non-pregnant smokers. Two focus groups were conducted with 13 professionals involved antenatal stop services (SSS). The data analysed thematically. themes extracted that describe health professionals' attitudes towards either lapses...
Although English Stop Smoking Services routinely offer dual nicotine replacement therapy (NRT) to help pregnant women quit smoking, little is known about how and tobacco smoke exposures following this compare with that from smoking. We compared, in when smoking after being offered NRT, saliva cotinine exhaled carbon monoxide (CO) concentrations numbers of daily cigarettes smoked.Secondary analysis data three sequential, observational, mixed-methods cohort studies conducted as part the...
This longitudinal study explores the lived experience of four couples where one person from each couple is prescribed an oxygen concentrator to use at home. Transcripts were analysed using interpretative phenomenological analysis. The findings reported here focus on two super-ordinate themes: ‘the journey acceptance’ and ‘negotiating changing relationships’. Participants described a gradual process accepting device into their lives, impact couple’s relationships role that expectations have...
Methylation of a CpG dinucleotide at cytosine C5 (mCpG)is major modification in vertebrate genomes associatedwith epigenetic gene silencing. methylation recruitsproteins which specifically recognise this motif and thesemethylated DNA binding proteins then recruit enzymeswhich chemically physically alter chromatin, inducingtranscriptional repression. Although most motifs aremethylated, short (500–2000 bp) CG-rich regions, knownas islands (CGIs), found within *60 % humangene promoters remain...
Abstract Background The effectiveness of Nicotine Replacement Therapy (NRT) for smoking cessation in pregnancy is limited by inconsistent and incorrect use. This paper describes the development process “Baby, Me, & NRT”, a novel pregnancy-specific intervention aimed at enhancing adherence to NRT. Methods An integrated approach was used, combining evidence, theory, stakeholders’ feedback, tailoring principles. involved six iterative steps: (1) synthesizing relevant published evidence...
Smoking during pregnancy is harmful to unborn babies, infants and women. Nicotine replacement therapy (NRT) offered as the usual stop-smoking support in UK. However, this often used insufficient doses, intermittently or for too short a time be effective. This randomised controlled trial (RCT) explores whether bespoke intervention, delivered pregnancy, improves adherence NRT effective cost-effective promoting smoking cessation. A two-arm parallel-group RCT was conducted pregnant women aged...
To explore the acceptability and perceived motivations barriers of using nicotine replacement therapy (NRT) to reduce number daily cigarettes smoked in pregnancy, rather than for stopping completely.
Introduction Pain surrounding major lower extremity amputations (MLEAs) in the vascular surgical patient can be severe, conferring significant debilitation from preoperative stage through to chronic rehabilitation phase. Although there is an evolving understanding of array existing analgesic medications and modalities, pain management this context continues challenging. A previous report UK revealed that MLEA practices may not optimal perspective patients. There are also limitations...
Evidence for the effectiveness of nicotine replacement therapy (NRT) smoking-cessation in pregnancy is weak. This has been attributed to insufficient dosing and low adherence. study investigated acceptability key messages delivery modes a behavioral intervention increase NRT adherence pregnancy. Semi-structured telephone interviews were carried out with pregnant or postpartum women aged ≥16 from across England, who had offered during as part quit attempt struggled (n = 10), focus group...
Journal Article The Path to Mechanized Shoe Production in the United States. By Ross Thomson. (Chapel Hill: University of North Carolina Press, 1989. xvi + 296 pp. $39.95.) Get access Philip Scranton Woodrow Wilson Center and Rutgers University, Camden Search for other works by this author on: Oxford Academic Google Scholar American History, Volume 77, Issue 3, December 1990, Pages 1022–1023, https://doi.org/10.2307/2079052 Published: 01 1990