A5034597558- Breast Cancer Treatment Studies
- Breast Implant and Reconstruction
- Reconstructive Surgery and Microvascular Techniques
- Cancer survivorship and care
- Head and Neck Cancer Studies
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 and healthcare impacts
- Palliative Care and End-of-Life Issues
- Vascular Malformations and Hemangiomas
- Ethics in Clinical Research
- Breast Lesions and Carcinomas
- LGBTQ Health, Identity, and Policy
- Global Cancer Incidence and Screening
- Body Image and Dysmorphia Studies
- Patient-Provider Communication in Healthcare
- Central Venous Catheters and Hemodialysis
- Economic and Financial Impacts of Cancer
- Lymphatic System and Diseases
- Cancer-related cognitive impairment studies
- Childhood Cancer Survivors' Quality of Life
- Cleft Lip and Palate Research
- Cancer Treatment and Pharmacology
- Vascular Malformations Diagnosis and Treatment
- Digital Imaging in Medicine
- Meta-analysis and systematic reviews
University of Amsterdam
2013-2025
Vrije Universiteit Amsterdam
2018-2024
Amsterdam University Medical Centers
2018-2024
St. Antonius Ziekenhuis
2024
Amsterdam UMC Location Vrije Universiteit Amsterdam
2017-2024
Ghent University Hospital
2024
Plastic Electronics (Netherlands)
2024
Brigham and Women's Hospital
2018-2023
Japanese Red Cross Narita Hospital
2022
Creative Commons
2021
Abstract Background The coronavirus disease 2019 (COVID-19) pandemic (officially declared on the March 11, 2020), and resulting measures, are impacting daily life medical management of breast cancer patients survivors. We evaluated to what extent these changes have affected quality life, physical, psychosocial well-being previously or currently being treated for cancer. Methods This study was conducted within a prospective, multicenter cohort survivors (Utrecht Multiple BREast intervention...
A critical barrier to outcome assessment in gender-affirming healthcare is the lack of a specific patient-reported measure (PROM). This phase I protocol describes an international collaboration between investigators Canada, Denmark, Netherlands and USA who have coalesced develop new PROM (ie, GENDER-Q) evaluate outcomes psychological, hormonal surgical treatments.This study uses interpretive description approach. Participants aged 16 years older seeking any form treatments centres located...
Objective: The aim was to compare the (sentinel) lymph node detection rate of indocyanine green (ICG)-fluorescent imaging versus standard-of-care 99m Tc-nanocoilloid for sentinel (SLN)-mapping. Background: current gold standard axillary staging in patients with breast cancer is biopsy (SLNB) using radio-guided surgery radioisotope technetium ( Tc), sometimes combined blue dye. A promising alternative fluorescent ICG. Methods: In this noninferiority trial, we enrolled 102 consecutive invasive...
Importance Despite the widespread use of breast implants, to date, no large-scale international studies on long-term revision incidence different implant types have been conducted. Objective To determine whether data could be combined using a harmonized dataset increase power and investigate clinically relevant differences in complication-related between types. Design, Setting, Participants This multicenter, population-based cohort study used from Australian Breast Device Registry Dutch...
Randomized controlled trials (RCTs)—the gold standard for evaluating the effects of medical interventions—are notoriously challenging in terms logistics, planning and costs. The cohort multiple randomized trial approach is designed to facilitate pragmatic evaluation (new) interventions a promising variation from conventional RCTs. In this paper, we evaluate methodological challenges conducting an RCT within cohort. We argue that equally valid results can be obtained conducted cohorts as...
The "cohort multiple randomized controlled trial," a new design for pragmatic trials, embeds trials within cohort. cohort RCT is an attractive alternative to conventional RCTs in fields where recruitment slow, (competing) interventions the same condition have be tested, are highly preferred by patients and doctors, risk of disappointment bias, cross-over, contamination considerable. To prevent these unwanted effects, provides information on randomization intervention group/arm only, only...
In oncology, RCTs are often beset by slow recruitment, limited generalizability, and strong preferences for interventions patients physicians. The cohort multiple randomized controlled trial (cmRCT) is an innovative design with the potential to overcome those challenges. cmRCT, a prospective serves as infrastructure RCTs. We implemented cmRCT in clinical breast cancer setting creating UMBRELLA—a large of DCIS patients/survivors. For all participants, data patient-reported outcomes (PROs,...
Background Existing patient‐reported outcome measures (PROMs) used to assess patients with head and neck cancer have methodologic content deficiencies. Herein, the development of a PROM that meets range clinical research needs across oncology is described. Methods After conceptual framework, which involved literature review, semistructured patient interviews, expert input, who were treated at Memorial Sloan Kettering Cancer Center recruited by their surgeon. The FACE‐Q Head Neck Module was...
The symptoms and appearance of vascular malformations can severely harm a patient's quality life. aim treatment generally is to improve condition-specific and/or appearance. Therefore, it highly important start testing effects in clinical studies from the perspective.To develop patient-reported outcome measure for measuring patients with malformations.A first draft was based on previously internationally developed core set. qualitative part this study involved interviews 14 patients, which...
Abstract Purpose Timing of Deep Inferior Epigastric artery Perforator (DIEP)-flap breast reconstruction in the context post-mastectomy radiotherapy for cancer patients is topic debate. We compared impact immediate (before radiotherapy) versus delayed (after DIEP-flap (IBR DBR) on short- and long-term patient-reported outcomes (PROs). Methods Within prospective, multicenter cohort (UMBRELLA), we identified 88 women who underwent or received PMRT. At 6 12 months post-mastectomy, as well (≥...
Coronary artery calcium (CAC) is a strong and independent predictor of cardiovascular disease (CVD) risk. This study assesses reproducibility automatic CAC scoring on radiotherapy planning computed tomography (CT) scans breast cancer patients, examines its association with traditional risk factors.This included 561 patients undergoing between 2013 2015. was automatically scored an algorithm using supervised pattern recognition, expressed as Agatston scores categorized into five categories...
The association between lymphedema of the arm and impaired health-related QoL (HR-QoL) has led to changes in clinical practice. However, data on breast (ie, edema) are lacking. We prospectively evaluated patient-reported prevalence determinants edema its effect HR-QoL pain.We included 836 patients undergoing breast-conserving surgery followed by radiotherapy October 2013 2016 (UMBRELLA cohort). Patient-reported edema, HR-QoL, pain were assessed means European Organisation for Research...
Klippel–Trenaunay syndrome (KTS) is a congenital malformation with prominent vascular anomalies. A persistent embryonic vein (PEV) may be located on the affected leg(s) of patients KTS. Our understanding PEVs legs limited and their nomenclature confusing. The objective this study was to obtain further insight in prevalence, etiology KTS propose standardized description anomalous leg veins We investigated 70 for presence (lateral marginal vein, LMV) by duplex ultrasonography. performed...
Background: The COVID-19 pandemic, and the resulting measures, are impacting daily life medical management of patients with breast cancer. We evaluated to what extent these changes have affected quality life, physical psychosocial wellbeing (being) treated for Materials methods: This study was conducted within prospective Utrecht cohort Multiple BREast cancer intervention studies Long-term evaluation (UMBRELLA). Shortly after implementation extra questionnaires were sent 1595 participants,...
Health apps are increasingly being used in clinical care and may hold significant theoretical potential. However, they often implemented before any research has been done to confirm actual benefits for patients, physicians, researchers.This study aimed explore experiences of patients health providers with the use a supportive breast cancer app during first 6 months following diagnosis, terms practice purposes.Between June 2013 April 2014, all ages were invited shortly after diagnosis app,...
Although peer support programs as a health resource have become increasingly popular, only limited studies evaluated the added value of one-on-one for breast cancer patients. This study aims to bridge knowledge gap by focusing on two related research topics. First, we emotional well-being and (unmet) needs regarding supportive care. Second, patients' perspectives their experiences after having support.A quantitative analysis was conducted provide insight in symptoms anxiety depression...
Informed consent for randomized trials often causes significant and persistent anxiety, distress confusion to patients. Where an experimental treatment is compared a standard care control, much of this burden potentially avoidable in the control group. We propose "just-in-time" which discussions take place two stages: initial research from all participants later specific only those assigned intervention. All patients are first approached informed about procedures, such as questionnaires or...
To evaluate the impact of chemotherapy on subjective cognitive functioning according to age in a large cohort breast cancer patients.Within UMBRELLA cohort, 715 patients with early-stage primary invasive (T1-3N0-1M0) were selected. Subjective function was assessed by means EORTC QLQ-C30 up 24 months and compared between treated without chemotherapy, for three different strata (355 < 55 years, 240 aged 55-65 120 > 65 years). Differences non-chemotherapy at time points linear mixed-effect...
Abstract Background Although deep inferior epigastric perforator (DIEP) flap breast reconstruction is the most widely used technique for autologous reconstruction, this leads to large scars in visible areas on and abdomen. So far, limited studies have thoroughly addressed impact of abdominal satisfaction Health-related Quality Life (HR-QoL). Objectives This research aimed determine whether women with no/minor scar symptoms after undergoing DIEP-flap differ perceived HR-QoL from symptomatic...
Abstract Purpose To evaluate patient-reported cosmetic satisfaction in women treated with radiation therapy for breast cancer and to determine the association between dissatisfaction quality of life (QoL) depression. Methods Within prospective UMBRELLA cohort, all patients ≥ 1 year after conserving treatment or mastectomy immediate reconstruction were selected. Self-reported was measured on a 5-point Likert scale. QoL, social functioning, emotional functioning using EORTC QLQ-C30 BR23 at 1,...