A5087514519- Chronic Disease Management Strategies
- Maternal Mental Health During Pregnancy and Postpartum
- Schizophrenia research and treatment
- Health Systems, Economic Evaluations, Quality of Life
- Pregnancy and Medication Impact
- Primary Care and Health Outcomes
- Dementia and Cognitive Impairment Research
- Health disparities and outcomes
- Inflammatory Bowel Disease
- Cardiac Health and Mental Health
- Mental Health Treatment and Access
- Statistical Methods and Bayesian Inference
- Microscopic Colitis
- Advanced Causal Inference Techniques
- Adrenal Hormones and Disorders
- Geriatric Care and Nursing Homes
- Hip and Femur Fractures
- Adolescent and Pediatric Healthcare
- Palliative Care and End-of-Life Issues
- Lipoproteins and Cardiovascular Health
- Statistical Methods and Inference
- Diabetes Management and Research
- Migration, Health and Trauma
- Bipolar Disorder and Treatment
- Blood Pressure and Hypertension Studies
University College London
2016-2025
Aarhus University
2015-2025
Aarhus University Hospital
2016-2025
British Heart Foundation
2025
Health Data Research UK
2025
University of Liverpool
2025
MRC Unit for Lifelong Health and Ageing
2025
Uppsala University
2024
University College Lahore
2024
Royal London Hospital
2024
Routinely collected health data, obtained for administrative and clinical purposes without specific a priori research goals, are increasingly used research. The rapid evolution availability of these data have revealed issues not addressed by existing reporting guidelines, such as Strengthening the Reporting Observational Studies in Epidemiology (STROBE). REporting studies Conducted using Data (RECORD) statement was created to fill gaps. RECORD an extension STROBE address items observational...
Abstract: Missing data are ubiquitous in clinical epidemiological research. Individuals with missing may differ from those no terms of the outcome interest and prognosis general. often categorized into following three types: completely at random (MCAR), (MAR), not (MNAR). In research, seldom MCAR. can constitute considerable challenges analyses interpretation results potentially weaken validity conclusions. A number methods have been developed for dealing data. These include complete-case...
People with severe mental illness (SMI) appear to have an elevated risk of death from cardiovascular disease, but results regarding cancer mortality are conflicting.To estimate this excess and the contribution antipsychotic medication, smoking, social deprivation.Retrospective cohort study.United Kingdom's General Practice Research Database. Patients Two cohorts were compared: people SMI diagnoses without such diagnoses. Main Outcome Measure Mortality rates for coronary heart disease (CHD),...
Objective To examine whether gender differences in primary care consultation rates (1) vary by age and deprivation status (2) diminish when for reproductive reasons or common underlying morbidities are accounted for. Design Cross-sectional study of a cohort patients registered with general practice. Setting UK care. Subjects Patients (1 869 149 men 1 916 898 women) 446 eligible practices 2010. Primary outcome measures rate. Results This analyses routinely collected data. The crude rate was...
In pharmacoepidemiology, routinely collected data from electronic health records (including primary care databases, registries, and administrative healthcare claims) are a resource for research evaluating the real world effectiveness safety of medicines. Currently available guidelines reporting using non-randomised, data—specifically REporting studies Conducted Observational Routinely Data (RECORD) Strengthening Reporting OBservational in Epidemiology (STROBE) statements—do not capture...
Few studies have investigated the incidence of eating disorders (EDs). Important questions about changes in diagnosed recent years, disorder and gender-specific onset case detection remain unanswered. Understanding is important for public health, clinical practice service provision. The aim this study was to estimate annual (age-specific, subtype-specific) ED: anorexia nervosa (AN), bulimia (BN) not otherwise specified (EDNOS) primary care over a 10-year period UK (2000-2009); examine within...
Objective To investigate trends in incident and prevalent diagnoses of type 2 diabetes mellitus (T2DM) its pharmacological treatment between 2000 2013. Design Analysis longitudinal electronic health records The Health Improvement Network (THIN) primary care database. Setting UK care. Participants In total, we examined 8 838 031 individuals aged 0–99 years. Outcome measures incidence prevalence T2DM 2013, the effect age, sex social deprivation on these were examined. Changes prescribing...
Objective. To assess trends in long-term (i.e. ≥3 months) oral glucocorticoid (GC) prescriptions over the past 20 years. Methods. Data of UK adult patients registered between January 1989 and December 2008 with general practices contributing to The Health Improvement Network (THIN) database were obtained. annual prevalence GC was assessed whole population specifically people RA, PMR/GCA, asthma, chronic obstructive pulmonary disease (COPD), Crohn's ulcerative colitis (UC). Trends 20-year...
An epidemiological study of British general practice patients who received oral glucocorticoids showed that these drugs were seven times as likely to attempt suicide with the same illness did not receive steroids. The increase was most prominent in younger people. Mania and delirium also significantly more common, particularly older men. Neuropsychiatric effects common receiving higher doses those previous mental disorders.
Routinely collected health data, for administrative and clinical purposes, without specific a priori research questions, are increasingly used observational, comparative effectiveness, services research, trials. The rapid evolution availability of routinely data has brought to light issues not addressed by existing reporting guidelines. aim the present project was determine priorities stakeholders in order guide development REporting studies Conducted using Observational Routinely-collected...
Autism has long been viewed as a paediatric condition, meaning that many autistic adults missed out on diagnosis children when autism was little known. We estimated numbers of diagnosed and undiagnosed people in England, examined how diagnostic rates differed by socio-demographic factors.This population-based cohort study prospectively collected primary care data from IQVIA Medical Research Data (IMRD) compared the prevalence to community estimate underdiagnosis. 602,433 individuals...
Current evidence of the association between prenatal exposure to glucocorticoids and long-term mental disorders is scarce has limitations.
Summary There have been widespread changes in land use the uplands of UK but implications for dispersal adult stages aquatic invertebrates are poorly known. We estimated lateral insects (Plecoptera, Trichoptera, Ephemeroptera) seven small, upland streams draining catchments under three categories (coniferous plantation forest, cleared moorland). Malaise traps were set out transects perpendicular to each stream. More than 29 000 taken, distributed among 15 species stoneflies, 40 caddisflies...
<b>Objective</b> To determine the extent to which antibiotics reduce risk of serious complications after common respiratory tract infections. <b>Design</b> Retrospective cohort study. <b>Setting</b> UK primary care practices contributing general practice research database. <b>Data source</b> 3.36 million episodes infection. <b>Main outcome measures</b> Risk in treated and untreated patients month diagnosis: mastoiditis otitis media, quinsy sore throat, pneumonia upper infection chest Number...
<b>Objectives</b> To estimate survival after a diagnosis of dementia in primary care, compared with people without dementia, and to determine incidence dementia. <b>Design</b> Cohort study using data from The Health Improvement Network (THIN), care database. <b>Setting</b> 353 general practices the United Kingdom providing THIN. <b>Participants</b> All adults aged 60 years or over first ever code for 1990 2007 (n=22 529); random sample five participants every participant matched on practice...
1. Emergence and inland dispersal of adult stoneflies (Plecoptera) caddisflies (Trichoptera) from Broadstone Stream, an acidic iron‐rich stream in southern England, were studied over 10 months 1996–1997. Fifteen pyramidal emergence traps placed randomly a 200‐m stretch. Three Malaise above the six more on each side (one wooded, one open) along transect at distances 1, 15, 30, 45, 60 75 m channel. 2. More than 16 000 stoneflies, belonging to 11 species, just under 400 (22 species) caught....
Propensity score based methods are used increasingly to evaluate the effectiveness of treatments when evidence from randomised trials is not available. However, users need be aware their strengths and limitations