A5085452163- Ethics in Clinical Research
- Health Systems, Economic Evaluations, Quality of Life
- Meta-analysis and systematic reviews
- Patient-Provider Communication in Healthcare
- Healthcare cost, quality, practices
- Ethics in medical practice
- Mental Health and Patient Involvement
- BRCA gene mutations in cancer
- Childhood Cancer Survivors' Quality of Life
- Metabolism and Genetic Disorders
- Obesity and Health Practices
- Genomics and Rare Diseases
- Adolescent and Pediatric Healthcare
- Clinical practice guidelines implementation
- Infant Development and Preterm Care
- Pediatric Pain Management Techniques
- Delphi Technique in Research
- Health disparities and outcomes
- Biomedical Ethics and Regulation
- Health Policy Implementation Science
- Obesity, Physical Activity, Diet
- Statistical Methods in Clinical Trials
- Palliative Care and End-of-Life Issues
- Maternal Mental Health During Pregnancy and Postpartum
- Ethics and Legal Issues in Pediatric Healthcare
Ottawa Hospital
2017-2025
Ottawa Hospital Research Institute
2018-2025
University of Ottawa
2014-2024
Deleted Institution
2024
SickKids Foundation
2019-2023
Western University
2023
Université Laval
2023
CHU Dinant Godinne UCL Namur
2023
University of Aberdeen
2023
Hospital for Sick Children
2019-2023
In pharmacoepidemiology, routinely collected data from electronic health records (including primary care databases, registries, and administrative healthcare claims) are a resource for research evaluating the real world effectiveness safety of medicines. Currently available guidelines reporting using non-randomised, data—specifically REporting studies Conducted Observational Routinely Data (RECORD) Strengthening Reporting OBservational in Epidemiology (STROBE) statements—do not capture...
Routinely collected health data, for administrative and clinical purposes, without specific a priori research questions, are increasingly used observational, comparative effectiveness, services research, trials. The rapid evolution availability of routinely data has brought to light issues not addressed by existing reporting guidelines. aim the present project was determine priorities stakeholders in order guide development REporting studies Conducted using Observational Routinely-collected...
Optimal health care delivery, both now and in the future, requires a continuous loop of knowledge generation, dissemination, uptake on how best to provide care, not just determining what interventions work but also ensure they are provided those who need them. The randomized clinical trial (RCT) is most rigorous instrument determine works care. However, major issues with trials enterprise lack integration delivery compromise medicine's ability serve society.
Outcome measurement in clinical genetics is problematic because the patient benefits are difficult to measure. The aim this qualitative grounded theory study was develop a theoretical framework describing from using services. Seven focus groups and 19 interviews were conducted with patients, group representatives, health professionals. Data analysis resulted construction of model empowerment summarizing Empowerment similar concept perceived personal control (PPC), measure PPC has been...
A bstract We present a novel technique for the analysis of proton-proton collision events from ATLAS and CMS experiments at Large Hadron Collider. For given final state choice kinematic variables, we build graph network in which individual appear as weighted nodes, with edges between defined by their distance space. then show that it is possible to calculate local metrics serve event-by-event variables separating signal background processes, evaluate these number different networks are...
The ways in which we access, acquire, and use data clinical trials have evolved very little over time, resulting a fragmented inefficient system that limits the amount quality of evidence can be generated.
Abstract The aim of this qualitative study was to explore the emotional effects that may be common many genetic conditions, or risk could appropriately targeted by clinical genetics services. sample comprised 52 individuals. Seven focus groups with patients services, their representatives from patient support organizations and healthcare providers were conducted. Focus supplemented 19 face‐to‐face interviews group representatives. audio taped, transcribed in full, analyzed using constant...
Background Infant vaccinations are necessary for public health, but painful, causing distress to the infant and caregivers. Breastfeeding sucrose effectively reduce infants' pain during vaccinations, these strategies recommended in health care provider (HCP)-targeted education vaccination guidelines. However studies show infrequently used. YouTube is a popular medium publicly share watch videos, many consumer posted videos distressed infants being vaccinated with no treatment. The aims of...
In 2018, the World Health Organization reported that depression is most common cause of disability worldwide, with over 300 million people currently living depression. Depression affects an individual's physical health and well-being, impacts psychosocial functioning, has specific negative short- long-term effects on maternal health, child developmental trajectories, family health. The aim these reviews to identify evidence benefits harms screening for in general adult population pregnant...
Abstract Background Addressing persistent and pervasive health inequities is a global moral imperative, which has been highlighted magnified by the societal impacts of COVID-19 pandemic. Observational studies can aid our understanding impact structural oppression based on intersection gender, race, ethnicity, age other factors, as they frequently collect this data. However, Strengthening Reporting Studies in Epidemiology (STROBE) guideline, does not provide guidance related to reporting...
Cluster randomised trials (CRTs) are used for evaluating health-related interventions in low-income and middle-income countries (LMICs) but raise complex ethical issues. To inform the development of future ethics guidance, we aim to characterise CRTs conducted exclusively LMICs by examining types clusters, settings, author affiliations primary clinical focus evaluate adherence trial registration reporting requirements over time.
C-C chemokine receptor type 5 (CCR5) antagonists may improve both acute stroke outcome and long-term recovery. Despite their evaluation in ongoing clinical trials, gaps remain the evidence supporting use.With a panel of patients with lived experiences stroke, we performed systematic review animal models that administered CCR5 antagonist assessed infarct size or behavioral outcomes. MEDLINE, Web Science, Embase were searched. Article screening data extraction completed duplicate. We pooled...
C-C chemokine receptor type 5 (CCR5) antagonists may improve both acute stroke outcome and long-term recovery. Despite their evaluation in ongoing clinical trials, gaps remain the evidence supporting use.With a panel of patients with lived experiences stroke, we performed systematic review animal models that administered CCR5 antagonist assessed infarct size or behavioral outcomes. MEDLINE, Web Science, Embase were searched. Article screening data extraction completed duplicate. We pooled...