A5015972538- Geriatric Care and Nursing Homes
- Dementia and Cognitive Impairment Research
- Health Systems, Economic Evaluations, Quality of Life
- Pharmaceutical Practices and Patient Outcomes
- Aging and Gerontology Research
- Ethics in Clinical Research
- Frailty in Older Adults
- Alzheimer's disease research and treatments
- Health and Medical Research Impacts
- Simulation-Based Education in Healthcare
- Cholinesterase and Neurodegenerative Diseases
- Palliative Care and End-of-Life Issues
- Acute Ischemic Stroke Management
- Global Health Workforce Issues
- Cultural Competency in Health Care
- Primary Care and Health Outcomes
- Interprofessional Education and Collaboration
- Aging, Health, and Disability
- Medication Adherence and Compliance
- Diversity and Career in Medicine
- Health Policy Implementation Science
- Biomedical Ethics and Regulation
- Nursing Diagnosis and Documentation
- Autism Spectrum Disorder Research
- Optimism, Hope, and Well-being
SUNY Upstate Medical University
2010-2024
Upstate University Hospital
2023-2024
Syracuse VA Medical Center
2019
Syracuse University
1995-2017
Florida State University
2017
University of Saskatchewan
2015
Auburn Community Hospital
2010
Stanford University
2003
Beijing Geriatric Hospital
1998
Medicina
1998
Importance There are limited efficacious treatments for Alzheimer disease. Objective To assess efficacy and adverse events of donanemab, an antibody designed to clear brain amyloid plaque. Design, Setting, Participants Multicenter (277 medical research centers/hospitals in 8 countries), randomized, double-blind, placebo-controlled, 18-month phase 3 trial that enrolled 1736 participants with early symptomatic disease (mild cognitive impairment/mild dementia) low/medium or high tau pathology...
Optimal health care delivery, both now and in the future, requires a continuous loop of knowledge generation, dissemination, uptake on how best to provide care, not just determining what interventions work but also ensure they are provided those who need them. The randomized clinical trial (RCT) is most rigorous instrument determine works care. However, major issues with trials enterprise lack integration delivery compromise medicine's ability serve society.
Abstract This study aimed to evaluate the sensitivity and specificity of subepidermal moisture (SEM), a biomarker employed for early detection pressure injuries (PI), compared “Gold Standard” clinical skin tissue assessment (STA), characterize timing SEM changes relative diagnosis PI. blinded, longitudinal, prospective enrolled 189 patients (n = 182 in intent‐to‐treat [ITT]) at acute post‐acute sites (9 USA, 3 UK). Data were collected from patients' heels sacrums using biocapacitance...
The ways in which we access, acquire, and use data clinical trials have evolved very little over time, resulting a fragmented inefficient system that limits the amount quality of evidence can be generated.
Background and Objectives: For persons with dementia, the relationships between caregiver burden, physical frailty, race, behavioral psychological symptoms (BPSD), other associated variables are poorly understood. Only one prior study examined among these but did not include which is an important social determinant of health outcomes in United States. To examine interactions, we conducted a cross-sectional exploratory based on model by Sugimoto colleagues. Materials Methods: The sample...
Strategies to reduce the documented disparities in health and care for rapidly growing numbers of older patients from diverse ethnic populations include increased cultural competence providers. To assist geriatric faculty medical other professional schools develop training their ethnogeriatric programs, University California Academic Geriatric Resource Program partnered with Ethnogeriatric Committee American Geriatrics Society a curricular framework. The framework includes core competencies...
The majority of clinical trials currently and historically do not include older adults or non-white participants. While more women are being recruited, their numbers still limited. It is very hard to interpret trial results apply them when participation in focus this article the lack by persons diverse races ethnicities presentation a model infrastructure grounded community engagement that proving be effective increasing interest African Americans research.
Background Rapid diagnosis for time-sensitive illnesses such as stroke, cardiac arrest, and septic shock is essential successful treatment. Much attention has therefore focused on new strategies rapid objective diagnosis, Point-of-Care Tests (PoCT) blood biomarkers. Here we use a biomimicry-based approach to demonstrate diagnostic platform, based enzymes tethered nanoparticles (NPs). As proof of principle, oriented immobilization pyruvate kinase (PK) luciferase (Luc) silica NPs achieve...
Use of high-dose statin therapy (HDST) in patients with stroke became standard clinical practice after the Stroke Prevention by Aggressive Reduction Cholesterol Levels (SPARCL) study, which mean age study population was approximately 63 years. Little data are available on adverse effects statins when used high doses adults older than 65 The objective this to assess magnitude HDST geriatric patients.This single-center, retrospective, case-control conducted at Upstate Medical University,...
The US Food and Drug Administration (FDA) approval of monoclonal antibodies (MAB) targeting amyloid protein for treatment Alzheimer's disease has ushered in a new era care. Disease-modifying therapies are now available to patients living with cognitive impairment confirmed presence brain beta-amyloid. Many geriatricians have voiced concerns even outright disagreement their clinical use.1, 2 these valid. For example, the accelerated Biogen's aducanumab was spectacular failure regulatory...
Angiosarcoma is a cancer that derived from endothelial cells line blood vessels and lymphatic channels. Cutaneous angiosarcoma can appear anywhere on the skin clinical presentation highly variable. Most cases scalp face de novo. Our case describes 91-year-old female with cutaneous angiosarcoma. serves to remind physicians an abnormal finding in older adults should raise their index of suspicion for early biopsy be performed.
Abstract Background Older adults, especially minoritized racial-ethnic groups, are historically underrepresented in biomedical research. This study summarizes the development and assesses impact of a review board involving multisectoral group stakeholders with goal increasing diversity older adults Methods A 25-member community members, caregivers, researchers, clinicians from Upstate New York reviewed 3 projects presented by clinician-scientists, pharmaceutical company between January...
Objectives To evaluate the efficacy and safety of megestrol for off-label use in older patients with weight loss. Design Retrospective, nonblinded cohort study. Setting Upstate University Hospital is a 420-bed facility academic medical center level 1 trauma center. Community 314-bed acute care/hospital/ambulatory care long-term hospital that also provides teaching services. Participants Patients 65 years age without malignancy or acquired immunodeficiency syndrome who were initiated...