A5010571731- Acute Lymphoblastic Leukemia research
- Lysosomal Storage Disorders Research
- Sarcoma Diagnosis and Treatment
- Glioma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Cellular transport and secretion
- Neuroblastoma Research and Treatments
- Carbohydrate Chemistry and Synthesis
- CNS Lymphoma Diagnosis and Treatment
- Trypanosoma species research and implications
- Glycosylation and Glycoproteins Research
- Neurofibromatosis and Schwannoma Cases
- Meningioma and schwannoma management
- Brain Metastases and Treatment
- Cancer-related cognitive impairment studies
- Thermal Regulation in Medicine
- Bone Tumor Diagnosis and Treatments
- Chronic Lymphocytic Leukemia Research
- Immunodeficiency and Autoimmune Disorders
- Cancer Treatment and Pharmacology
- Cardiac tumors and thrombi
- Vascular Malformations Diagnosis and Treatment
- Cardiac Arrest and Resuscitation
Tel Aviv University
2015-2025
Schneider Children's Medical Center
2015-2025
University of Pennsylvania
1981-2023
Icahn School of Medicine at Mount Sinai
2020-2023
Mount Sinai Beth Israel
2022
Rabin Medical Center
2003-2021
Rafael Advanced Defense Systems (Israel)
2013-2021
John Wiley & Sons (United States)
2019
Charles River Laboratories (Netherlands)
2019
Nassau University Medical Center
2014-2018
Importance There are limited efficacious treatments for Alzheimer disease. Objective To assess efficacy and adverse events of donanemab, an antibody designed to clear brain amyloid plaque. Design, Setting, Participants Multicenter (277 medical research centers/hospitals in 8 countries), randomized, double-blind, placebo-controlled, 18-month phase 3 trial that enrolled 1736 participants with early symptomatic disease (mild cognitive impairment/mild dementia) low/medium or high tau pathology...
Ewing sarcoma (EWS) is a highly metastatic malignancy in young patients. Ovarian cryopreservation often an option for fertility preservation cancer patients of reproductive age, specifically minors. Thus, the possibility ovarian involvement EWS needs to be elucidated.Eight aged 13-20 years with participated study. samples were fixed and prepared light microscopy, frozen liquid nitrogen RNA extraction followed by RT-PCR. Histological studies, including immunostaining adhesion receptor CD99,...
In an examination of the biologic differences between neuroblastoma Stage IV-S (metastases to liver, skin, or bone marrow but not bone), which has a high likelihood spontaneous regression, and IV is usually fatal, 13 children with disease 17 were studied at diagnosis shortly thereafter. Serum ferritin levels elevated in 15 disease, IV-S. E-rosette inhibitory factor was present serum 12 patients, detected patients. All patients had levels. Elevated appear distinguish from (N Engl J Med. 1981;...
SCURVY is a rare disorder in the United States because of wide availability fresh fruits and vegetables frequent supplementation common packaged foods with vitamin C. Although C levels leukocytes are reduced many patients iron overload due to repeated blood transfusions,1 clinical scurvy has not been reported this group. We have studied patient homozygous β-thalassemia overload, who had two episodes despite normal intake Investigation stores before treatment during recovery showed that...
To evaluate the rates of endocrine abnormalities in survivors childhood brain tumors and identify risk factors.The medical charts patients were reviewed for background, disease-related treatment-related data. Endocrine dysfunction was determined by clinical laboratory evaluation.The study group included 114 with a mean age 15.57 ± 5.93 years. Mean at tumor diagnosis 7.07 5.42 years, follow-up 12.8 6.25 Fifty-seven (50%) had an abnormality. The occurrence several significantly associated...
The course of three patients indicated that both types reaction, Shwartzman and Arthus-like, can occur in hyperacute rejection human-kidney allografts the late histologic appearances may be indistinguishable. In first patient failure kidney occurred four hours, association with development a bleeding diathesis. Sequential were those progressive fibrin deposition resembling generalized reaction. second patient, two consecutive kidneys from same donor rejected within minutes revascularization...
In experimental animals, a reduction in renal mass leads to glomerulosclerosis of the residual parenchyma and eventual failure. humans, however, data on influence nephrectomy or agenesis future functional parameters hypertension are as yet controversial.To evaluate blood-pressure patterns children with solitary kidney result either unilateral (URA) uninephrectomy (UNX) correlate them increase size remaining kidney.Twenty-eight were divided into two groups: URA group, 18 subjects (13 male...
Abstract BACKGROUND Tumors in the Ewing family (EFTs) are second most common bone tumors children and adolescents. Despite aggressive chemotherapy, one‐third of patients with localized tumor still may develop recurrences. This implies that not all cells eradicated have a level residual disease. EFTs characterized by specific chromosomal translocations result chimeric transcripts can be detected reverse transcriptase‐polymerase chain reaction (RT‐PCR) analysis. METHODS The authors report...
Purpose Most children today with bone sarcomas undergo limb-sparing surgery. When treating younger than 12 years of age, the result is significant limb length discrepancy (LLD). One solutions use an expandable endoprosthesis. Methods A retrospective analysis 38 skeletally immature patients sarcoma lower in whom different types endoprostheses were used from January 1988 to December 2005 included. All under age 14 years. There 26 osteosarcoma and Ewing's sarcomas. The data collected included...
Methotrexate can influence the central nervous system through several metabolic toxic pathways. These effects be categorized as immediate, acute to subacute, or chronic neurologic syndromes. The subacute syndrome occurs frequently in lymphoblastic leukemia treatment protocols, generally manifesting with focal signs and changes seen on magnetic resonance imaging single photon emission computed tomography. While some patients neurotoxicity is transient benign allows for continuation of...