A5031162237- Lysosomal Storage Disorders Research
- Glycosylation and Glycoproteins Research
- Cellular transport and secretion
- Carbohydrate Chemistry and Synthesis
- Sexual function and dysfunction studies
- Platelet Disorders and Treatments
- Hormonal and reproductive studies
- Blood groups and transfusion
- Invertebrate Immune Response Mechanisms
- Developmental Biology and Gene Regulation
- Pain Mechanisms and Treatments
- RNA Research and Splicing
- Chromosomal and Genetic Variations
- MicroRNA in disease regulation
- Tumors and Oncological Cases
- Salivary Gland Tumors Diagnosis and Treatment
- Lung Cancer Treatments and Mutations
- Viral Infectious Diseases and Gene Expression in Insects
- Lung Cancer Diagnosis and Treatment
- Biochemical and Molecular Research
- Oral and Maxillofacial Pathology
- Silk-based biomaterials and applications
- Biosimilars and Bioanalytical Methods
- Neutropenia and Cancer Infections
- Erythropoietin and Anemia Treatment
Gilead Sciences (United States)
2023-2024
Seoul National University Bundang Hospital
2022-2024
National University College
2024
New Generation University College
2024
Inje University Busan Paik Hospital
2024
Amgen (United States)
2017-2022
Creative Commons
2022
Stanford University
2015-2016
Jeonbuk National University
2003-2015
The University of Texas Southwestern Medical Center
2007-2014
The balance between germ-line stem cell (GSC) self-renewal and differentiation in Drosophila ovaries is mediated by the antagonistic relationship Nanos (Nos)-Pumilio translational repressor complex, which promotes GSC self-renewal, expression of Bam, a key factor. Here, we find that Bam Nos proteins are expressed reciprocal patterns young germ cells. Repression Bam-expressing cells depends on sequences nos 3'-UTR, suggesting regulated repression. Ectopic causes GSCs, this activity endogenous...
To estimate the risk of thrombocytopenia in various cancers and chemotherapy regimens.Structured patient-level data from Flatiron Health Electronic Record database were used to identify adult patients who received for a solid tumor or hematologic malignancy 2012 2017. Three-month cumulative incidence was assessed based on platelet counts, overall by grade thrombocytopenia. Co-occurrence anemia, neutropenia, leukopenia evaluated.Of 15,521 with tumors, 13% had within 3 months (platelet count <...
Double-stranded RNA-binding proteins (dsRBPs), such as R2D2 and Loquacious (Loqs), function in tandem with Dicer (Dcr) enzymes RNA interference (RNAi). In Drosophila , Dcr-1/Loqs Dcr-2/R2D2 complexes generate microRNAs (miRNAs) small interfering RNAs (siRNAs), respectively. Although does not regulate siRNA production, Dcr-2 coordinately bind siRNAs to promote assembly of the siRNA-induced silencing (siRISC) complexes. Conversely, Loqs enhances miRNA production. It is uncertain if Dcr-1...
During Drosophila oogenesis, germline stem cell (GSC) identity is maintained largely by preventing the expression of factors that promote differentiation. This accomplished via activity several genes acting either in GSC or its niche. The translational repressors Nanos and Pumilio act GSCs to prevent differentiation, probably inhibiting translation early differentiation factors, whereas niche signals silencing transcription factor Bam. We have found DNA-associated protein Stonewall (Stwl)...
Gaucher disease is caused by mutations in the gene for human glucocerebrosidase, a lysosomal enzyme involved intracellular hydrolysis of glucosylceramide. While over 150 different glucocerebrosidase have been identified patients with disease, not all reported fully characterized as being causative. One such mutation E326K mutation, which results from G to A nucleotide substitution at genomic position 6195 and has type 1, 2 3 disease. However, each instance, was found on same allele another...
This study evaluated noninferiority of darbepoetin alfa versus placebo for overall survival (OS) and progression-free (PFS) in anemic patients with NSCLC treated to a 12.0-g/dL hemoglobin (Hb) ceiling. Adults stage IV expected receive two or more cycles myelosuppressive chemotherapy Hb less than equal 11.0 g/dL were randomized 2:1 blinded 500 μg every 3 weeks. The primary endpoint was OS; stratified Cox proportional hazards model used evaluate (upper confidence limit hazard ratio [HR] <...
Antibodies to first-generation recombinant thrombopoietin (TPO) neutralized endogenous TPO and caused thrombocytopenia in some healthy subjects chemotherapy patients. The second-generation receptor agonist romiplostim, having no sequence homology TPO, was developed avoid immunogenicity. This analysis examined development of binding neutralising antibodies romiplostim or among adults with immune (ITP) 13 clinical trials a global postmarketing registry. 60/961 (6·2%) patients from...
Mutations in the gene encoding for lysosomal enzyme glucocerebrosidase (GBA) result Gaucher disease. In this study, seven novel missense mutations (A136E, H162P, K198E, Y205C, F251L, Q350X and I402F) a splice site mutation (IVS10+2T-->A) were identified by direct sequencing of three amplified segments gene. Five found patients with neuronopathic forms disease, two which, K198E appear to be associated type 2
This study was designed to evaluate the causative organisms in young male soldiers with clinical signs and symptoms after sexual contact that suggests a diagnosis of urethritis.Between June 2012 January 2015, patients urethritis had resulted from within 3 months participated this study. All were evaluated using urinalysis screened for Neisseria gonorrhoeae (NG), Chlamydia trachomatis (CT), Ureaplasma urealyticum (UU), Mycoplasma genitalium (MG), hominis (MH), herpes simplex virus (HSV) type...
Basal cell adenoma (BCA) is a rare benign tumor within the salivary glands. adenocarcinoma (BCAC), malignant counterpart of BCA, also an exceedingly with very limited clinical studies conducted. This study aims to investigate characteristics, demographics, and surgical outcomes patients diagnosed BCA BCAC parotid gland.
TPS8121 Background: Management of resectable NSCLC involves surgery with perioperative systemic therapy. Immune checkpoint inhibitors (CPIs) and targeted therapies are now used in the setting, leading to improved survival outcomes. The combination dom (anti–T-cell immunoglobulin ITIM domain [TIGIT]) zim (anti–programmed death protein 1 [PD-1]) has shown promising antitumor activity a manageable safety profile metastatic may provide an opportunity improve clinical outcomes setting...