A5041277249- HIV/AIDS Research and Interventions
- HIV Research and Treatment
- HIV/AIDS drug development and treatment
- Antibiotic Resistance in Bacteria
- Bacterial Identification and Susceptibility Testing
- HIV-related health complications and treatments
- Sepsis Diagnosis and Treatment
- Antimicrobial Resistance in Staphylococcus
- Mycobacterium research and diagnosis
- Urinary Tract Infections Management
- Streptococcal Infections and Treatments
- Antifungal resistance and susceptibility
- Tuberculosis Research and Epidemiology
- Infective Endocarditis Diagnosis and Management
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotics Pharmacokinetics and Efficacy
- Antibiotic Use and Resistance
- Bacterial biofilms and quorum sensing
- Cytomegalovirus and herpesvirus research
- Hemodynamic Monitoring and Therapy
- Infections and bacterial resistance
- Nosocomial Infections in ICU
- Hepatitis C virus research
- Fungal Infections and Studies
- Immune Response and Inflammation
Yonsei University
2013-2025
Severance Hospital
2012-2025
Ontario Institute for Cancer Research
2024
Kaiser Permanente Stockton Medical Offices
2024
Coalition for Epidemic Preparedness Innovations
2023
Dartmouth College
2022
University of Kentucky
2022
University of California, San Francisco
2021
Amgen (United States)
2018-2020
University of Maryland, Baltimore
2015-2020
No therapies for targeting
ABSTRACT We investigated the phenotypic and genetic properties of metallo-β-lactamase-producing Pseudomonas isolates collected at a tertiary-care hospital in Korea since 1995. The prevalence imipenem resistance among aeruginosa reached 16% 1997, when 9% resistant organisms were found to produce VIM-2 β-lactamase, class B enzyme previously only P. from Europe. VIM-2-producing putida also detected. Resistance was transferable both these species PAO4089Rp by filter mating, although determinant...
Sepsis, including severe sepsis and septic shock, is a major cause of morbidity mortality. Albumin C-reactive protein (CRP) are considered as good diagnostic markers for sepsis. Thus, initial CRP albumin levels were combined to ascertain their value an independent predictor 180-day mortality in patients with shock.We conducted retrospective cohort study involving 670 (>18 years old) who admitted the emergency department had received standardized resuscitation algorithm (early goal-directed...
Red blood cell distribution width (RDW) is known to be a predictor of severe morbidity and mortality in some chronic diseases such as congestive heart failure. However, our knowledge, little about RDW patients with Gram-negative bacteremia, major nosocomial cause intra-abdominal infections, urinary tract primary bacteremia. Therefore, we investigated whether an independent Clinical characteristics, laboratory parameters, outcomes 161 bacteremia from November 2010 March 2011 diagnosed at...
To evaluate the effects of transfusions in patients with severe sepsis and septic shock on mortality.Propensity-matched analysis a prospective observational database (April 2005 to February 2009).Twenty-two medical surgical intensive care units 12 teaching hospitals Korea.One thousand fifty-four community-acquired shock.None.Of 1,054 patients, 407 (38.6%) received blood transfusion. The mean pretransfusion hemoglobin level was 7.7 ± 1.2 g/dL. Transfused had higher 28-day in-hospital...
Stenotrophomonas maltophilia is a nosocomial pathogen associated with high morbidity and mortality, particularly in immunocompromised or critically ill patients. In this study, we investigated the risk factors for mortality patients S. bacteremia. Retrospectively, medical records from all bacteremia between December 2005 2014 at Severance Hospital, 2000-bed tertiary care hospital Seoul, Korea, were reviewed. Analysis was performed to identify 28-day mortality. total, 142 enrolled study. The...
Infection is a major cause of mortality in patients with systemic lupus erythematosus (SLE). This study describes infectious complications SLE and analyzes the risk factors for infection at time diagnosis during course case-control study. Of 110 enrolled, 42 (38%) had least 1 episode disease. The incidence disease was 4.4/100 patient-years (py) total follow-up duration 954 y. In multivariate analysis, independent predictors were an activity index (SLEDAI) > 12 (p = 0.01), C3 levels < 90...
Purpose: Over the last 30 years, Serratia marcescens (S. marcescens) has emerged as an important pathogen, and a common cause of nosocomial infections.The aim this study was to identify risk factors associated with mortality in patients S. bacteremia.Materials Methods: We performed retrospective cohort 98 who had one or more blood cultures positive for between January 2006 December 2012 tertiary care hospital Seoul, South Korea.Multiple were compared association 28-day all-cause...
University Hospitals in KoreaA prospective multicenter observational study was performed to investigate the epidemiology and outcomes of community-acquired severe sepsis septic shock.Subjects included 1,192 adult patients admitted 22 participating intensive care units (ICUs) 12 university hospitals Korean Sepsis Registry System from April, 2005 through February, 2009.Male accounted for 656 (55%) patients.Mean age 65.0 ± 14.2 yr.Septic shock developed 740 (62.1%) patients.Bacteremia present...
Severe sepsis is associated with an unacceptably high rate of mortality. Recent studies revealed elevated levels vascular endothelial growth factor (VEGF), a potent angiogenic and permeability factor, in patients sepsis. There was also association between VEGF severity. Here we investigate the effects anti-VEGF antibody (Bevacizumab, Bev) experimental model sepsis.Human umbilical vein cells (HUVECs), murine cecal ligation puncture (CLP), endotoxemia models were used. HUVECs treated...
Abstract Unfortunately, the options for treating multidrug-resistant (MDR) Acinetobacter baumannii ( A . ) infections are extremely limited. Recently, fosfomycin and minocycline were newly introduced as a treatment option MDR infection. Therefore, we investigated efficacy of combination colistin with minocycline, respectively, therapeutic in pneumonia. We examined carbapenem-resistant isolated from clinical specimens at Severance Hospital, Seoul, Korea. The effect fosfomycin, on bacterial...
Abstract Background Crohn’s disease (CD) and gastrointestinal Behçet’s (GIBD) are chronic inflammatory bowel disorders with similar presentations. Although they share treatment guidelines, empirical observations suggest worse postoperative outcomes in GIBD. This study compared long-term surgical between CD GIBD patients undergoing primary resection. Methods We conducted a retrospective cohort of resection for or at single center (2001-2021). was confirmed by pathology, while diagnosed using...
Abstract Introduction Viral blips have been associated with larger reservoir size and slower decay. Earlier antiretroviral therapy (ART) initiation may decrease the risk of blips. Methods We analyzed participants from U.S. Military HIV Natural History Study an estimated seroconversion date, viral suppression ≤400 copies/mL within 1 year after starting ART, at least 3 RNA measurements suppression. A blip was 401-1000 preceded followed by without changing ART. Cox proportional hazards models...
Since the diagnosis of extrapulmonary tuberculosis (EPT) is largely depended on physician's suspicion in respect disease, we believed that it would be worthwhile to scrutinize clinical characteristics EPT. Thus, here present retrospectively evaluated manifestations patients who were diagnosed as EPT cases a tertiary referral care hospital. Medical records 312 patients, having at Yongdong Severance hospital from January 1997 December 1999, reviewed retrospectively. In total 149 (47.8%) males...
This study investigated the molecular mechanisms of carbapenem resistance in clinical isolates Klebsiella pneumoniae from Korea and outcomes resistant K. infection. Sixteen showing to carbapenems collected a tertiary-care hospital were examined for resistance. PCR sequencing experiments detected bla DHA-1 AmpC β-lactamase gene all 16 isolates, whilst genes extended-spectrum β-lactamases 12 isolates. SDS-PAGE indicated that lacked 35 kDa and/or 36 outer-membrane proteins (OMPs). Sequence...
ABSTRACT We retrospectively analyzed the performance of Architect HIV antigen/antibody (Ag/Ab) combination assay in a tertiary health care center with situation low prevalence. The specificity and positive predictive value (PPV) were 99.78% 31.21%, respectively. However, PPV could increase to 99.99% 89.70% using an arbitrary cutoff value.