A5033852136- Dementia and Cognitive Impairment Research
- Alzheimer's disease research and treatments
- Neurological Disease Mechanisms and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Infectious Encephalopathies and Encephalitis
- Neurological Disorders and Treatments
- Frailty in Older Adults
- Peripheral Neuropathies and Disorders
- Traumatic Brain Injury and Neurovascular Disturbances
- Autoimmune Neurological Disorders and Treatments
- Genetic Neurodegenerative Diseases
- Functional Brain Connectivity Studies
- Epilepsy research and treatment
- Advanced Neuroimaging Techniques and Applications
- Alcoholism and Thiamine Deficiency
- Inflammatory Myopathies and Dermatomyositis
- Mitochondrial Function and Pathology
- Obesity, Physical Activity, Diet
- T-cell and Retrovirus Studies
- Glycogen Storage Diseases and Myoclonus
- GDF15 and Related Biomarkers
- Physical Activity and Health
- Thyroid Disorders and Treatments
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Sarcoidosis and Beryllium Toxicity Research
Oita University
2013-2025
Oita Prefectural Hospital
2023-2025
Oita University Hospital
2017
Neurology, Inc
2016
Faculty (United Kingdom)
2015
Importance There are limited efficacious treatments for Alzheimer disease. Objective To assess efficacy and adverse events of donanemab, an antibody designed to clear brain amyloid plaque. Design, Setting, Participants Multicenter (277 medical research centers/hospitals in 8 countries), randomized, double-blind, placebo-controlled, 18-month phase 3 trial that enrolled 1736 participants with early symptomatic disease (mild cognitive impairment/mild dementia) low/medium or high tau pathology...
Background: The development of evidence-based interventions for delaying or preventing cognitive impairment is an important challenge. Most previous studies using self-report questionnaires face problems with reliability and consistency due to recall bias misclassification among older people. Therefore, objective measurement lifestyle components needed confirm the relationships between factors function. Aims: current study examined relationship collected wearable sensors function...
Abstract Background and Objectives The GAA repeat expansion within the fibroblast growth factor 14 ( FGF14 ) gene has been found to be associated with late‐onset cerebellar ataxia. This study aimed investigate genetic causes of ataxia in patients Japan. Methods We collected a case series 940 index who presented chronic remained genetically undiagnosed after our preliminary screening. To locus, we employed an integrated diagnostic strategy that involved fluorescence amplicon length analysis...
Abstract Human T-cell leukemia virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic neurodegenerative disease. This multicenter, randomized phase 3 study evaluated the efficacy and safety of 0.3 mg/kg intravenous mogamulizumab, monoclonal antibody targeting-CC chemokine receptor 4, every 12 weeks in HAM/TSP patients. comprised 24-week double-blind, placebo-controlled period, open-label extension treatment period. The primary endpoint was proportion...
<h3>Importance</h3> Understanding the association of lifestyle factors with mild cognitive impairment enables development evidence-based interventions for delaying impairment. <h3>Objective</h3> To explore whether objectively measured factors, such as physical activity, conversation, and sleep, are associated cortical amyloid burden cerebral glucose metabolism in older adults <h3>Design, Setting, Participants</h3> This cohort study included 855 community-dwelling Usuki, Oita Prefecture,...
This study examined regional cerebral blood flow (rCBF) in Alzheimer's disease (AD) patients with and without subclinical hypothyroidism (SCH).Eleven AD SCH 141 underwent brain perfusion single photon emission computed tomography (SPECT). The SPECT data were analyzed by statistical parametric mapping (SPM8) FineSRT.AD showed a significantly decreased rCBF mainly the temporal lobe thalamus, whereas those parietotemporal cingulate gyrus as well frontal lobe.Our findings suggest that may affect...
Background: This study examined the effect of white matter lesions (WMLs) on regional cerebral blood flow (rCBF) in patients with Alzheimer's disease (AD). Methods: Ninety-eight AD were included (40 men and 58 women; mean age, 78.1 years). Cognitive function was assessed using Mini-Mental State Examination. Brain magnetic resonance imaging (MRI) 99mTc ethyl cysteinate dimer single photon emission computed tomography performed all subjects. divided into two subgroups according to presence...
Benign gynecologic tumor, such as uterine adenomyosis, has been suggested to develop hypercoagulability. Although some cases of cerebral infarction associated with adenomyosis have reported, the mechanism hypercoagulation initiated by is still not clear, and therapeutic strategy uncertain. A 44-year-old woman was presented our department headache, left hand weakness, gait disturbance during her menstrual phase. She had a history infertility treatment for 18 years heavy bleeding. Magnetic...
The aim of the present study was to evaluate relationship between baseline white matter lesions (WML) and changes in regional cerebral blood flow during longitudinal follow up patients with Alzheimer's disease (AD).A total 38 AD were included (16 men, 22 women; mean age 77.8 years). All evaluated using Mini-Mental State Examination brain perfusion single-photon emission computed tomography at an approximately 2-year up. divided into two subgroups according presence WML on magnetic resonance...
Brain perfusion may differ between patients with corticobasal syndrome (CBS) and without aphasia.Twenty-six (9 males 17 females; mean age 76 ± 5.3 years) CBS were enrolled in the study. MRI single-photon emission computed tomography performed all subjects. Language was evaluated using Standard Test of Aphasia. The divided into two subgroups according to presence or absence progressive aphasia. Differences regional cerebral blood flow (rCBF) groups detected based on voxel-by-voxel group...
Power spectral analysis (PSA) of the variation in heart rate is useful determining relative activity sympathetic and parasympathetic nerves. In this study, PSA was used to investigate relationship between abnormalities autonomic nerve function presence thyroid disorders patients with autoimmune diseases. The low frequency (LF) or high (HF) components R-R variations were determined by PSA. coefficient time intervals (CV(R-R)) positively correlated HF healthy subjects. untreated hyperthyroid...
Tick-borne encephalitis (TBE) is an infection of the central nervous system caused by tick-borne virus (TBEV). TBE endemic in parts Europe and Asia. TBEV transmitted to humans primarily Ixodes ticks. There have been 5 cases identified Japan, all on northern island Hokkaido. Rodents with antibodies ticks throughout indicating that might be undiagnosed Japan. Residual serum cerebrospinal fluid (CSF) collected 2010-2021 from 520 patients ≥1 year-of-age previously hospitalized or meningitis...
Physical inactivity and sleep disturbances are major problems in an ageing society. There is increasing evidence that physical activity associated with quality. However, the association between daily walking steps remain unclear. This prospective study examined relationship objectively measured parameters Japanese community-dwelling older adults. In total, 855 individuals aged 65 above, uninterrupted follow-up from August 2015 to March 2016, were enrolled. The participants wore a wristband...
. Here we report a genetically confirmed case of Creutzfeldt-Jakob disease with prion protein gene codon 180 mutation presenting atypical magnetic resonance imaging findings. The present exhibited an acute onset and lateralized neurologic signs, progressive cognitive impairment. No myoclonus or periodic synchronous discharges on electroencephalography were observed. Diffusion-weighted images revealed areas high signal intensity in the right frontal temporal cortices at that extended to whole...
The Montreal Cognitive Assessment (MoCA) test has high sensitivity and specificity for detecting mild cognitive impairment or early dementia. How the MoCA score relates to findings of positron emission tomography imaging, however, remains unclear.This prospective study examined relationship between Japanese version (MoCA-J) brain amyloid deposition cerebral glucose metabolism among subjects with impairment.A total 125 underwent MoCA-J test, amyloid- 18F-fluorodeoxyglucose- tomography. Linear...
This study examined the relationship between baseline white matter lesions (WMLs) and progression of cognitive decline in patients with late-onset Alzheimer's disease (AD).Fifty-six AD were included (23 men, 33 women; mean age, 77.8 years). All subjects treated acetylcholinesterase inhibitors followed up for approximately 1 year. The Mini-Mental State Examination (MMSE) score was assessed at least twice to evaluate progressive impairment. underwent brain MRI divided into WMLs(-), mild...
Background: White matter lesions are frequently found in mild cognitive impairments and Alzheimer’s disease. Matrix metalloproteinases the tissue inhibitor of implicated amyloid-β catabolism blood brain barrier permeability. However, it remains unclear whether they associated with white Objective: The aim this study was to examine association matrix degeneration subjects amyloid-positive impairment. Methods: Thirty amnestic impairment (14 men 16 women; mean age, 75.6 ± 5.8 years) underwent...
Aim The aim of the present study was to examine differences in brain perfusion single‐photon emission computed tomography patterns compared dementia with Lewy bodies (DLB) or without cingulate island sign (CIS). Methods A total 43 patients DLB and 63 Alzheimer's disease (AD) were included study. CIScore determined based on posterior area occipital cortex using eZIS software. analyzed receiver operating characteristic curve analysis. Statistical parametric mapping 8 used for voxel‐by‐voxel...
Abstract Background Developing a screening method for identifying individuals at higher risk of elevated brain amyloid burden is important to reduce costs and patients in clinical trials on Alzheimer’s disease or the setting. We developed machine learning models using objectively measured lifestyle factors predict positron emission tomography. Methods Our prospective cohort study non-demented, community-dwelling older adults aged ≥ 65 years was conducted from August 2015 September 2019...
<b><i>Background:</i></b> Cerebrovascular white matter lesions (WMLs) are associated with cognitive impairment in patients subcortical vascular dementia. We performed a comprehensive gene expression analysis to elucidate genes WML development chronic cerebral hypoperfusion rat model. <b><i>Methods:</i></b> Brains of rats bilateral carotid ligation (2VO, n = 10) and sham-operated (n 5-10/group) were removed on days 1, 7, or 28 after surgery....
This study aimed to explore whether cerebrospinal fluid (CSF) levels of matrix metalloproteinases (MMPs), and their inhibitors (TIMPs) were associated with brain amyloid deposition, cortical glucose metabolism, white matter lesions (WMLs) in individuals amnestic mild cognitive impairment (MCI). A total 33 MCI (mean age, 75.6 years) underwent 11C-Pittsburgh compound B positron emission tomography (PiB-PET), 18F-fluorodeoxyglucose tomography, magnetic resonance imaging or computed CSF...
A 20-year-old man was admitted to our hospital with status epilepticus (SE).He had a high fever and tested polymerase chain reaction-positive for coronavirus disease 2019 (COVID-19).Brain magnetic resonance imaging showed gyral pattern of restricted diffusion cortical swelling hyperperfusion in the left hemisphere (Pic-