A5053775328- Mitochondrial Function and Pathology
- Genetic Neurodegenerative Diseases
- Parkinson's Disease Mechanisms and Treatments
- Vasculitis and related conditions
- Sarcoidosis and Beryllium Toxicity Research
- Alzheimer's disease research and treatments
- Polyomavirus and related diseases
- Intracranial Aneurysms: Treatment and Complications
- Viral Infections and Vectors
- Acute Ischemic Stroke Management
- Vector-borne infectious diseases
- Cerebrovascular and Carotid Artery Diseases
- Bacterial Infections and Vaccines
- Neurosurgical Procedures and Complications
- Eosinophilic Disorders and Syndromes
- Material Dynamics and Properties
- Potassium and Related Disorders
- Energy Harvesting in Wireless Networks
- Multiple Sclerosis Research Studies
- Neurological disorders and treatments
- Peripheral Neuropathies and Disorders
- Cardiovascular Effects of Exercise
- Ion Transport and Channel Regulation
- Systemic Lupus Erythematosus Research
- Cerebral Venous Sinus Thrombosis
Beppu Medical Center
2021-2025
National Hospital Organization
2021-2025
Kyushu University
2012-2023
Omuta hospital
2022
Aso Iizuka Hospital
2015
National Institute of Technology, Miyakonojo College
2007
Nagoya University
1991
Clinical manifestations of Lyme borreliosis (LB), caused by Borrelia burgdorferi sensu lato (Bbsl), include erythema migrans, neuroborreliosis (LNB), carditis, and arthritis. LB is a notifiable disease in Japan with <30 surveillance-reported cases annually, predominately from Hokkaido Prefecture. However, LB, including LNB, may be under-diagnosed since diagnostic tests are not readily available. We sought to determine if LNB could cause previously undiagnosed encephalitis or meningitis...
Spinocerebellar ataxia type 8 (SCA8) is a neurodegenerative condition that presents with several neurological symptoms, such as cerebellar ataxia, parkinsonism, and cognitive impairment. It caused by CTA/CTG repeat expansion on chromosome 13q21 (ataxin opposite strand [ATXN8OS]). However, the pathological significance of this remains unclear. Moreover, abnormal expansions in ATXN8OS have also been reported other diseases, including progressive supranuclear palsy. In study, we analyzed all...
Dynactin forms a protein complex with dynein that retrogradely transports cargo along microtubules. Dysfunction of this dynein-dynactin causes several neurodegenerative diseases such as Perry syndrome, motor neuron and progressive supranuclear palsy. Recently, we reported colocalization phosphorylated α-synuclein (p-SNCA) the largest subunit dynactin (DCTN1) in Lewy body (LB)-like structures syndrome. Previous reports have not focused on relationship between synucleinopathies. Thus, examined...
Tick-borne encephalitis (TBE) is an infection of the central nervous system caused by tick-borne virus (TBEV). TBE endemic in parts Europe and Asia. TBEV transmitted to humans primarily Ixodes ticks. There have been 5 cases identified Japan, all on northern island Hokkaido. Rodents with antibodies ticks throughout indicating that might be undiagnosed Japan. Residual serum cerebrospinal fluid (CSF) collected 2010-2021 from 520 patients ≥1 year-of-age previously hospitalized or meningitis...
A 38-year-old woman with untreated Graves' disease was admitted to our hospital because of headache and diplopia for 3 months. neuro-ophthalmic examination showed bilateral papilledema abducens nerve paralysis. The cerebrospinal fluid pressure extremely high. Brain magnetic resonance imaging cerebral venous thrombosis in the superior sagittal right transverse sigmoid sinuses. Laboratory investigations revealed elevated factor VIII von Willebrand levels. patient recovered after...
The protein μ‐crystallin (CRYM) is a novel component of the marsupial lens that has two functions: it key regulator thyroid hormone transportation and reductase sulfur‐containing cyclic ketimines. In this study, we examined changes expression pattern CRYM in different rat organs during development using immunohistochemistry immunoblotting. As reportedly expressed corticospinal tract, also investigated human cases amyotrophic lateral sclerosis (ALS) immunohistochemistry. brain, was cerebral...
Central pontine myelinolysis (CPM), which was originally considered to be the result of rapid correction chronic hyponatremia, is not necessarily accompanied by hyponatremia or drastic changes in serum sodium level. Here, we report a case an anorexic 55-year-old male with history pharyngo-laryngo-esophagogastrectomy, initially hospitalized status epilepticus. Although his consciousness gradually recovered as were controlling convulsion, it deteriorated again new onset anisocoria, and...
症例は53歳男性．左方注視時複視で発症し，頭部MRIで造影効果のある多発脳病変を認めた．悪性リンパ腫が疑われ前医で脳生検を行ったが悪性所見はなく，血管周囲にリンパ球の集簇を認めることから免疫関連性脳炎が疑われ，ステロイドパルス，シクロホスファミド投与，血漿交換等の免疫療法を行うも治療に反応しなかった．当院に転院後，脳生検を再度行い，最終的に原発性中枢神経系血管炎と診断した．ステロイドパルスとメトトレキサートの投与を行い病巣は縮小した．一度の脳生検では正確な病理診断がつかず，その後も侵襲的な治療が必要な場合は，複数回脳生検を行い正確な診断に至る必要がある．
Multiple system atrophy (MSA) is a sporadic adult‐onset neurodegenerative disease. It has recently been shown that patients with MSA accompanied by cognitive decline display numerous neuronal cytoplasmic inclusions (NCIs) in the limbic neurons. We examined potential mechanisms underlying formation of these NCIs determining mitochondrial function and statuses RNA processing analyzing 12 pathologically confirmed cases MSA. Among them, four had impairment Semiquantitative evaluation using...
Myotonic dystrophy type 1 (DM1) is an inherited autosomal-dominant condition that induces altered splicing of transcripts, including MAPT, leading to a distinctive abnormal deposition tau protein in the CNS. We characterized isoforms depositions brains 4 patients with classic DM1 by immunohistochemistry using isoform-specific antibodies. All patients, those presenile age, showed numerous neurofibrillary tangles (NFTs) both 3-repeat and 4-repeat limbic area mild involvement cerebral cortex....
Eosinophilic granulomatosis with polyangiitis (EGPA) is a small vessel necrotizing vasculitis characterized by asthma and eosinophilia. Ischemic stroke rare complication of the disease. We herein report case involving 77-year-old woman sinusitis who developed embolic splenic infarctions. Laboratory tests revealed hypereosinophilia elevated troponin-T N-terminal pro-brain natriuretic peptide. Antineutrophil cytoplasmic antibodies (ANCA) studies were negative. Skin biopsy showed infiltration...
症例は44歳男性である．2011年1月頃より両手指がふるえ始め，集中力の低下や「視点が合わない」などの視覚異常も出現．7月頃より両下肢のつっぱり感と筋痛が出現し，転倒するようになったため，前医受診した．CK 26,890 U/lと異常高値をみとめ，筋炎うたがいで当院紹介入院となった．針筋電図でmyokymic dischargeを多発性にみとめ，抗voltage-gated potassium channel（VGKC）複合体抗体が強陽性であったためIsaacs症候群と診断した．抗てんかん薬では効果不十分で，ステロイドパルス療法により劇的に症状は改善した．治療方法として，血漿交換/吸着療法や免疫グロブリン大量療法を第一選択にすることが多いが，ステロイド療法が著効する症例も一部存在するものと考えられる．
症例は40歳女性，全身性エリテマトーデスと重症筋無力症に対しプレドニゾロンとタクロリムスを内服中，腰部の疼痛と右優位の下肢脱力が出現した．右腰背部の帯状疱疹及びL1以下のBrown-Séquard症候群を認め，髄液中の水痘・帯状疱疹ウイルス（varicella zoster virus; VZV）-DNA陽性であり，MRI所見と併せVZV関連脳血管炎・脊髄炎と診断した．アシクロビル治療にも関わらず多発脳出血・脳梗塞による意識障害を来し，発症17日目に死亡した．病理解剖では，脊髄は横断性壊死に陥っており，神経細胞およびマクロファージがVZV免疫染色で陽性を示した．免疫抑制下でのVZV再活性化は致死的な転機をたどることがあり注意を要する．
Abstract Background Postvaccination acute disseminated encephalomyelitis (ADEM) may develop 2–30 days after vaccination. However, ADEM following pneumococcal vaccination has never been reported. Case presentation We report a 73‐year‐old woman with She developed fever and consciousness disturbance 17 the second administration of 23‐valent polysaccharide vaccine (PPSV23). Head magnetic resonance imaging (MRI) revealed numerous T2‐high lesions, mainly involving cerebral cerebellar white matter...
We report a case of granulomatosis with polyangiitis (GPA) presenting hypertrophic pachymeningitis huge brain tumor-like lesion. A 57-year-old man acutely developed consciousness disturbance. Magnetic resonance imaging revealed right frontal lobe mass thickened, contrast-enhanced dura. Computed tomography sinusitis and multiple lung nodules. The presence proteinase 3-anti-neutrophil cytoplasmic antibody indicated GPA. Histopathology the excised tissues thrombovasculitis heavy neutrophilic...
Platypnea-orthodeoxia syndrome is a rare clinical entity characterized by dyspnea and arterial blood deoxygenation in sitting position. An 89-year-old woman was diagnosed with subacute cerebellar infarction. Her oxygen saturation decreased to 88% position, resulting dyspnea. Cardiological thoracic computed tomography revealed an unruptured aortic aneurysm, enlarged ascending aorta, right atrial compression, counterclockwise rotation of the heart. anatomical distortion septum induced these...