A5058675749- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Amyotrophic Lateral Sclerosis Research
- Parkinson's Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Acute Ischemic Stroke Management
- Neurological Disorders and Treatments
- Genetic Neurodegenerative Diseases
- Pluripotent Stem Cells Research
- Neurogenesis and neuroplasticity mechanisms
- Neurogenetic and Muscular Disorders Research
- Mitochondrial Function and Pathology
- Peripheral Neuropathies and Disorders
- RNA regulation and disease
- Cholinesterase and Neurodegenerative Diseases
- Autoimmune Neurological Disorders and Treatments
- S100 Proteins and Annexins
- Stroke Rehabilitation and Recovery
- Nerve injury and regeneration
- Cerebrovascular and Carotid Artery Diseases
- Multiple Sclerosis Research Studies
- Mesenchymal stem cell research
- Neurological diseases and metabolism
- Barrier Structure and Function Studies
Okayama University
2016-2025
Okayama University Hospital
2023-2025
National Center of Neurology and Psychiatry
2023
Kitakyushu City Hospital Organization
2013-2020
Tohoku University
1956-2018
Hokkaido University Hospital
2018
Sumitomo Dainippon Pharma (Japan)
2017
Columbia University
2011-2012
Shibaura Institute of Technology
2012
University of Miami
2012
Recent studies have revealed that the adult mammalian brain has capacity to regenerate some neurons after various insults. However, precise mechanism of insult-induced neurogenesis not been demonstrated. In normal brain, GFAP-expressing cells in subventricular zone (SVZ) lateral ventricles include a neurogenic cell population gives rise olfactory bulb only. Herein, we report evidence that, stroke, these are capable producing new outside bulbs. SVZ labeled by cell-type-specific viral...
The brain is susceptible to oxidative stress, which associated with various neurological diseases. Edaravone (MCI-186, 3-methyl-1 pheny-2-pyrazolin-5-one), a free radical scavenger, has promising effects by quenching hydroxyl radicals (∙OH) and inhibiting both ∙OH-dependent ∙OH-independent lipid peroxidation. was initially developed in Japan as neuroprotective agent for acute cerebral infarction later applied clinically treat amyotrophic lateral sclerosis (ALS), neurodegenerative disease....
Abstract The subventricular zone (SVZ) is the largest germinal in mature rodent brain, and it continuously produces young neurons that migrate to olfactory bulb. Neural stem cells this region generate migratory neuroblasts via highly proliferative transit-amplifying cells. Wnt/β-catenin signaling pathway partially regulates proliferation neuronal differentiation of neural progenitor embryonic brain. Here, we studied role β-catenin adult mouse SVZ. β-Catenin-dependent expression a...
Stroke is a major neurologic disorder. Induced pluripotent stem (iPS) cells can be produced from basically any part of patients, with high reproduction ability and pluripotency to differentiate into various types cells, suggesting that iPS provide hopeful therapy for cell transplantation. However, transplantation ischemic brain has not been reported. In this study, we showed the fate in mouse model transient middle cerebral artery occlusion (MCAO). Undifferentiated (5 × 10 5 ) were...
Abstract Interleukin (IL)‐6 expression transiently increases in the acute phase of cerebral ischemia. To investigate physiological significance endogenous IL‐6 and to identify main signal pathway for action IL‐6, we administered anti‐mouse receptor monoclonal antibody (IL‐6RA), which blocks signaling, mice immediately after a 45‐min period middle artery occlusion (MCAO). At 6 h MCAO, IL‐6RA administration had resulted significant reduction amount phosphorylated transducer activator...
In the ischemic brain, reperfusion with tissue plasminogen activator (tPA) sometimes causes catastrophic hemorrhagic transformation (HT); however, mechanism remains elusive. Here, we show that basement membrane, and not endothelial cells, is vulnerable to ischemic/reperfusion injury tPA treatment. We treated a spontaneously hypertensive rat model of middle cerebral artery occlusion (MCAO) vehicle alone, or free radical scavenger, edaravone, plus tPA. Light electron microscopic analyses each...
Recent studies have suggested that autophagy is involved in a neural death pathway following cerebral ischemia. In vivo detection of could be important for evaluating ischemic cell damage human stroke patients. Using novel green fluorescent protein (GFP)-fused microtubule-associated 1 light chain 3 (LC3) transgenic (Tg) mice, imaging was performed at 1, and 6 d after 60 min transient middle artery occlusion (tMCAO). Ex autophagy, testing the inhibitor 3-methyladenine (3-MA), estern blot...
Induced pluripotent stem (iPS) cells may provide cures for various neurological diseases. However, undifferentiated iPS have high tumorigenicity, and evaluation of the fates, especially in pathologic condition model, is needed. In this study, we demonstrated effect ischemic to fates a mouse model transient middle cerebral artery occlusion (MCAO). Undifferentiated were characterized with immunofluorescent staining. The (5 × 10 5 ) injected into ipsilateral striatum cortex after 24 h MCAO....
Neural stem/progenitor cells (NSCs/NPCs) give rise to neurons, astrocytes, and oligodendrocytes. It has become apparent that intracellular epigenetic modification including DNA methylation, in concert with extracellular cues such as cytokine signaling, is deeply involved fate specification of NSCs/NPCs by defining cell-type specific gene expression. However, it still unclear how differentiated neural retain their attributes repressing cellular properties characteristic other lineages. In...
Abstract Hepatocyte growth factor (HGF) and glial cell line‐derived neurotrophic (GDNF) are strong factors. However, their potentials in neurogenesis, angiogenesis, synaptogenesis, antifibrosis have not been compared. Therefore, we investigated these effects of HGF GDNF cerebral ischemia the rat. Wistar rats were subjected to 90 min transient middle artery occlusion (tMCAO). Immediately after reperfusion, or was given by topical application. BrdU injected intraperitoneally twice daily 1, 2,...
Background and purpose The influence of metabolic syndrome (MetS) on cognitive affective functions in patients with Alzheimer's disease ( AD ) was examined. Methods A total 570 were divided into two subgroups depending waist circumference WC (normal versus achieving Japanese diagnostic criteria MetS). Afterwards, the control subgroup defined as those normal no vascular risk factors VRF s). MetS ‐MetS) group who had or more s to qualify having MetS. Cognitive functions, insulin resistance,...
Although chronic cerebral hypoperfusion (CCH) may affect Alzheimer's disease (AD) pathogenesis, the mechanism remains elusive. In present study, we investigated role of CCH on an AD mouse model in neurovascular unit, cerebrovascular remodeling, and trophic coupling. Moreover, examined protective effect galantamine. transgenic mice (APP23) were subjected to bilateral common carotid arteries stenosis with ameroid constrictors for slowly progressive hypoperfusion. exacerbated neuronal loss...
Abstract Background This prospective study investigated the superiority of transarterial chemoembolization (TACE) with miriplatin over TACE epirubicin regarding overall survival (OS) in patients unresectable hepatocellular carcinoma (HCC). Methods Patients HCC were randomized 1:1 to receive or lipiodol. The primary endpoint was OS; secondary endpoints percentages who achieved treatment effect (TE) 4 (100% necrotizing tumor reduction), duration time failure, and adverse events (AEs). OS...
To compare the effectiveness of combination therapy with cholinesterase inhibitors (ChEI) plus memantine in all AD patients and older (age >75 years).The Okayama Memantine Study was used to clinical effects donepezil (n = 61) or galantamine 53) patients, separately, six batteries at baseline, 6 months ChEI only monotherapy, 3, 6, 12 after addition treatment schedule (18 total).The resulted stabilization Mini-Mental State Examination scores Hasegawa dementia rating for months, then...
Recently, aging societies have been showing an increasingly strong relationship between Alzheimer's disease (AD) and chronic cerebral hypoperfusion (HP). In the present study, we created a new mouse model for AD with HP, investigated its clinical pathological characteristics. di sease transgenic mice (APP23) were subjected to bilateral common carotid arteries stenosis ameroid constrictors slowly progressive HP. contrast simple APP23 mice, HP exacerbated motor cognitive dysfunctions white...
Abstract Oxidative stress is associated with the degeneration of both motor neurons and skeletal muscles in amyotrophic lateral sclerosis (ALS). A free radical scavenger edaravone has been proven as a therapeutic drug for ALS patients, but neuroprotective mechanism oxidative not fully investigated. In this study, we investigated model mice bearing sensor nuclear erythroid 2‐related factor 2 (Nrf2) G93A‐human Cu/Zn superoxide dismutase (Nrf2/G93A) treated by edaravone. vivo Nrf2 imaging...