A5007613905- Thyroid Disorders and Treatments
- Orthopedic Surgery and Rehabilitation
- Diabetes and associated disorders
- Pain Mechanisms and Treatments
- Bone and Joint Diseases
- Hematological disorders and diagnostics
- Hip disorders and treatments
- Blood properties and coagulation
- Health Promotion and Cardiovascular Prevention
- Knee injuries and reconstruction techniques
- Bone fractures and treatments
- Heart Rate Variability and Autonomic Control
- Elbow and Forearm Trauma Treatment
- Drug Transport and Resistance Mechanisms
- Shoulder and Clavicle Injuries
- Acute Myeloid Leukemia Research
- Bone Tumor Diagnosis and Treatments
- Orthopaedic implants and arthroplasty
- Neuroscience and Neuropharmacology Research
- Blood Pressure and Hypertension Studies
- Chronic Disease Management Strategies
- Healthcare cost, quality, practices
- Cancer, Stress, Anesthesia, and Immune Response
- Adipose Tissue and Metabolism
- Polyomavirus and related diseases
Toyama University Hospital
2017-2023
University of Toyama
2010-2022
Hoshi University
2010-2022
Stanford University
2021-2022
Shiga University of Medical Science
2010-2021
Stanford Medicine
2019
Ebara (Japan)
2010
Kyushu University
2006
National Defense Medical College
1989-2005
Dokkyo University
1995-2004
Complex regional pain syndrome (CRPS) is a chronic disorder with clear acute-to-chronic transition. Preclinical studies demonstrate that toll-like receptor 4 (TLR4), expressed by myeloid-lineage cells, astrocytes, and neurons, mediates sex-dependent transition to pain; however, evidence lacking on which exact TLR4-expressing cells are responsible. We used complementary pharmacologic transgenic approaches in mice more specifically manipulate TLR4 outline its contribution the from CRPS based...
Brain-derived neurotrophic factor (BDNF) stimulates peripheral nerve regeneration. However, the origin of BNDF and its precise effect on repair have not been clarified. In this study, we examined role BDNF from bone marrow-derived cells (BMDCs) in post-injury repair. Control heterozygote knockout mice (BDNF+/−) received a left sciatic crush using cerebral blood clip. Especially, for evaluation BMDCs, studies with marrow transplantation (BMT) were performed before injury. We evaluated...
Neuropathic pain is the most difficult to manage in clinic, and sleep problems are common among patients with chronic including neuropathic pain. In present study, we tried visualize intensity of by assessing neuronal activity investigated disturbance under a pain-like state mice using functional magnetic resonance imaging (fMRI) electroencephalogram (EEG)/electromyogram (EMG), respectively. Furthermore, effect gabapentin (GBP) on these phenomena. model pain, sciatic nerve ligation caused...
Syndrome X is used to describe a constellation of factors that lead coronary heart disease (CHD): hypertension, hyperinsulinemia, impaired glucose tolerance, and an abnormality in lipid metabolism. We investigated the relationship between serum levels C-peptide immunoreactivity (CPR) diabetic complications 256 patients with type-2 diabetes mellitus. The level CPR was measured by radioimmunoassay (RIA). Diabetic were divided into 3 groups according as follows: low (n = 19, <0.7 ng/ml), normal...
Our tibial fracture orthopaedic injury model in mice recapitulates the major manifestations of complex trauma, including nociceptive sensitization, bone fracture, muscle fibrosis and fibre loss. Delayed exercise after trauma results decreased improved pain Losartan, an angiotensin-receptor blocker with anti-fibrotic abilities, effect on post-injury recovery may provide enhanced option for those who are unable to ABSTRACT: Chronic disability limb public health problems. Early mobilization...
A new method of vascularised tibial grafting has been developed for the treatment avascular necrosis (AVN) talus and secondary osteoarthritis (OA) ankle. We used 40 cadavers to identify vascular anatomy distal tibia in order establish how elevate a graft safely. Between 2008 2012, eight patients (three male, five female, mean age 50 years; 26 68) with isolated AVN 12 (four 58 23 76) OA underwent bone from either revascularise or arthrodesis. The radiological clinical outcomes were evaluated...
To elucidate the relationship between recovery of skin temperature in an extremity after exposure to cold water and various factors associated with diabetes, we measured type 2 diabetic patients (N = 61) control subjects 16). A thermo-tracer was used thermographic measurements. The right third toe each subject immersed at 0 °C for 10 sec. Rt represents rate t min exposure. significantly reduced every 5 20 period following compared subjects. group exhibited a positive correlation R20...
Power spectral analysis (PSA) of the variation in heart rate is useful determining relative activity sympathetic and parasympathetic nerves. In this study, PSA was used to investigate relationship between abnormalities autonomic nerve function presence thyroid disorders patients with autoimmune diseases. The low frequency (LF) or high (HF) components R-R variations were determined by PSA. coefficient time intervals (CV(R-R)) positively correlated HF healthy subjects. untreated hyperthyroid...
Abstract Aims We investigated the relationship between interleukin (IL)‐6 and coagulation, i.e. whether changes in plasma IL‐6 are associated with those coagulation markers (D dimer fibrinogen) after glycaemic control sulphonylurea or insulin poorly controlled patients Type 2 diabetes. Methods studied 42 diabetes, including 19 subsequently treated sulphonylurea, 23 48 subjects. All were poor hospitalized for 3 weeks. At beginning end of treatment, we measured concentrations IL‐6, fibrinogen,...
It is controversial whether an increase in the QT dispersion (QTd) on electrocardiogram (ECG) reflects cardiac autonomic neuropathy diabetic patients. In current study, QTd was compared 60 type 2 patients and 30 healthy subjects, its association with investigated. An increased found patients, to subjects. The had significant negative associations log of low high frequency power (log LF HF, respectively) spectral analyses (PSA) heart rate variations systolic blood response during standing (Δ...
BK polyomavirus (BKPyV) infection causes various diseases in immunocompromised patients. Cells from human lung and kidney were infected with BKPyV treated commercially available intravenous immunoglobulin G (IVIG). Its effects on replication spread of investigated, focusing administration timing. IVIG treatment 3 h after suppressed assessed by real-time PCR expression the VP1 capsid protein large T-antigen. effectively reduced number BKPyV-infected cells 2 weeks an antibody titer-dependent...
This uncontrolled study investigated the effects of using alpha 1-blocker doxazosin (2 mg or 4 daily for 3 months) to treat 21 hypertensive patients with type 2 diabetes, including eight obese individuals (body mass index [BMI] > = 25.0 kg/m2). A significant reduction in systolic and diastolic blood pressure, beginning after 1 month treatment, was seen. There no change BMI. Although there obvious improvement glucose metabolism, treatment noticeably reduced insulin resistance significantly...
This retrospective cohort study compared the results of vascularised and non-vascularised anterior sliding tibial grafts for treatment osteoarthritis (OA)of ankle secondary to osteonecrosis talus.We reviewed clinical radiological outcomes 27 patients who underwent arthrodesis with either or (conventional) grafts, comparing (clinical scores, proportion successful union time union) between two groups. The outcome was assessed using Mazur American Orthopaedic Foot Ankle Society (AOFAS)...
Background: Excessive use of broad spectrum antibiotics is related to the spread drug resistant bacterial strains in community. Aim/methods: The effects immediate testing for C reactive protein (CRP) and white blood cell count (WBC) on physicians’ choices antibiotic was investigated patients with acute infection. Acutely febrile new outpatients were randomised into two groups: group 1 (147 patients) underwent CRP WBC before initial consultation (advance testing). Prescriptions compared those...