A5081413351- Speech and Audio Processing
- Pain Mechanisms and Treatments
- Speech Recognition and Synthesis
- Advanced Data Compression Techniques
- Cancer Treatment and Pharmacology
- Neuropeptides and Animal Physiology
- Cardiac Ischemia and Reperfusion
- Receptor Mechanisms and Signaling
- Eicosanoids and Hypertension Pharmacology
- Nitric Oxide and Endothelin Effects
- Advanced Adaptive Filtering Techniques
- Microbial Natural Products and Biosynthesis
- Neuroscience and Neuropharmacology Research
- Cardiac Imaging and Diagnostics
- Advanced Optical Network Technologies
- Ion channel regulation and function
- Nerve injury and regeneration
- Cardiac electrophysiology and arrhythmias
- Software-Defined Networks and 5G
- Pharmacological Receptor Mechanisms and Effects
- Neurotransmitter Receptor Influence on Behavior
- Semiconductor Lasers and Optical Devices
- Monoclonal and Polyclonal Antibodies Research
- Photonic and Optical Devices
- Diet and metabolism studies
Kyoto University Hospital
2016-2025
Wakayama Medical University
2023-2025
Tokyo Institute of Technology
1992-2024
Kyoto University
2016-2023
Wakayama University
2023
Therapeutics Clinical Research
2022
National Cancer Center Hospital East
2020-2021
Fujitsu (Japan)
2006-2020
University of Maryland, Baltimore
2014-2019
Shinrakuen Hospital
2018
The authors describe a mel-cepstral analysis method and its adaptive algorithm. In the proposed method, apply criterion used in unbiased estimation of log spectrum to spectral model represented by coefficients. To solve nonlinear minimization problem involved they give an iterative algorithm whose convergence is guaranteed. Furthermore, derive for introducing instantaneous estimate gradient criterion. system implemented with IIR filter which has exponential transfer function, stability also...
Abstract Environmental enrichment is an experimental paradigm that increases brain‐derived neurotrophic factor (BDNF) gene expression accompanied by neurogenesis in the hippocampus of rodents. In present study, we investigated whether enriched environment could cause epigenetic modification at BDNF mice. Exposure to for 3–4 weeks caused a dramatic increase mRNA BDNF, but not platelet‐derived growth A (PDGF‐A), PDGF‐B, vascular endothelial (VEGF), nerve (NGF), epidermal (EGF), or glial...
Leucine-Rich Repeat Kinase 2 (LRRK2) is a causative gene for the autosomal dominant form of Parkinson's disease (PD). The encodes approximately 280 kDa LRRK2 protein composed domains such as leucine-rich repeats, Ras in complex proteins (Roc) followed by C-terminal Roc (COR), mitogen-activated kinase (MAPKKK) and WD40. However, normal function well its contribution to pathogenesis PD remains largely unknown. Here we describe localization Golgi apparatus, plasma membrane synaptic vesicles...
Abstract The spectral envelope of speech can be represented efficiently by the log magnitude spectrum on nonlinear frequency scale, which is close to mel scale (called mel‐log spectrum). cepstrum defined its Fourier coefficients also considered have a suitable property as parameter represent envelope. So far, no satisfactory filter has been reported for synthesis approximating spectrum. This paper presents method constructing approximation (MLSA) filter, relatively simple structure and low...
A multiplex analysis for profiling the expression of candidate genes along with epigenetic modification may lead to a better understanding complex machinery neuropathic pain. In present study, we found that partial sciatic nerve ligation most remarkably increased monocyte chemotactic protein 3 (MCP-3, known as CCL7) total 33 541 in spinal cord, which lasted 4 weeks. This increase MCP-3 gene transcription was accompanied by decreased trimethylation histone H3 at Lys27 promoter. The associated...
Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting and disabling side effect of taxane anticancer agents. We prospectively evaluated the efficacy cryotherapy for CIPN prevention. Breast cancer patients treated weekly with paclitaxel (80 mg/m2 one hour) wore frozen gloves socks on dominant 90 minutes, including entire duration drug infusion. Symptoms sides were compared those untreated (nondominant) sides. The primary end point was incidence assessed by changes in tactile...
We attempted to assess the regulatory role of EF-hand motifs recently detected in primary structure porcine 80-kDa diacylglycerol kinase (DGK) (Sakane, F., Yamada, K., Kanoh, H., Yokoyama, C., and Tanabe, T. (1990) Nature 344, 345-348). By using DGK purified from thymus cytosol, we found that this isozyme indeed bound 2 mol Ca2+ per enzyme with high affinity (apparent dissociation constant, kd = 0.3 microM). The binding was cooperative a Hill coefficient 1.4. next studied effect 1 x 10(-5) M...
1. Using a calcium buffer system, the effect of severe lack on shape K‐contracture guinea‐pig's taenia coli was studied. Under conditions lack, initial phasic response preferentially affected and it disappeared completely at concentrations below 10 −7 M , while ensuing tonic persisted, though considerably diminished in size, even concentration −8 . 2. In calcium‐free media, various multivalent cations, which according to Frank (1962) can support skeletal twitch muscle fibre solution,...
A variety of mechanisms that contribute to the accumulation age-related damage and resulting brain dysfunction have been identified. Recently, decreased neurogenesis in hippocampus has recognized as one dysfunction. However, molecular mechanism with aging is still unclear. In present study, we investigated whether decreases accompanied by activation microglia astrocytes, which increases expression IL-1beta hippocampus, vitro treatment neural stem cells directly impairs neurogenesis. Ionized...
Neuropathic pain is the most difficult type of to control, and patients lose their motivation for purposive pursuit with a decrease in quality life. Using functional magnetic resonance imaging analysis, we demonstrated that blood oxygenation level-dependent signal intensity was increased ipsilateral nucleus accumbens (N.Acc.) following peripheral nerve injury. microRNAs are small, noncoding RNA molecules direct post-transcriptional suppression gene expression, play an important role...
Abstract Impairment of peripheral neurons by anti-cancer agents, including taxanes and platinum derivatives, has been considered to be a major cause chemotherapy-induced neuropathy (CIPN), however, the precise underlying mechanisms are not fully understood. Here, we examined direct effects agents on Schwann cells. Exposure primary cultured rat cells paclitaxel (0.01 μM), cisplatin (1 or oxaliplatin (3 μM) for 48 h induced cytotoxicity reduced myelin basic protein expression at concentrations...
Insomnia is a common problem for people with chronic pain. Cortical GABAergic neurons are part of the neurobiological substrate that underlies homeostatic sleep regulation. In present study, we confirmed sciatic nerve ligation caused thermal hyperalgesia and tactile allodynia in mice. this experimental model neuropathic pain, found an increase wakefulness decrease non-rapid eye movement under pain-like state. Under these conditions, membrane-bound GABA (γ-aminobutyric acid) transporters...
1060-nm VCSELs with low power dissipation and high reliability are demonstrated. We designed double intracavity structure to achieve for the optical interconnection. performed evaluations of an error-free 10-Gbps operation at bias current, recorded per data rate 0.14 mW/Gbps was achieved. Even though modulation amplitude input signal as small 75 mV <sub xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">p-p</sub> , extinction ratio 6.5 dB observed. From...
Abstract Dysesthesia is an unpleasant abnormal sensation, which often accompanied by peripheral neuropathy or vascular impairment. Here, we examined the roles of transient receptor potential ankyrin 1 (TRPA1) in dysesthesia-like behaviours elicited hindlimb ischemia (15–60 min) tightly compressing and reperfusion releasing ligature. The paw-withdrawal responses to tactile stimulation were reduced during lasted for a while after reperfusion. Hindlimb ischemia/reperfusion spontaneous licking...
The purpose of this study was to determine whether endothelin and receptors play an important role in the development cardiac hypertrophy due pressure overload vivo. Cardiac produced by placing a constricting clip around suprarenal abdominal aorta rats. Hemodynamic parameters plasma ventricular concentrations endothelin-1 (ET-1) were measured control unoperated rats, 30 min, 2 6 h, 1 8 days after operation rats sham-operated density dissociation constant ET-1 binding sites also sham...
We purified phosphatidic acid phosphatase (EC 3.1.3.4) 2300-fold from porcine thymus membranes. The enzyme was solubilized with beta-octyl glucoside and Triton X-100 fractionated ammonium sulfate. purification then achieved by chromatography in the presence of Sephacryl S-300, hydroxylapatite, heparin-Sepharose, Affi-Gel Blue. final preparation gave a single band M(r) = 83,000 on sodium dodecyl sulfate-polyacrylamide gel electrophoresis under reducing nonreducing conditions. native enzyme,...
Seven drugs were tested for their antiarrhythmic effects on ventricular arrhythmias 24 and 48 hr after two-stage coronary ligation in conscious beagles. Venous blood samples drawn plasma drug assays. Minimum effective concentrations of calculated from derived concentration-time curves. Effective minimum the suppression were: disopyramide, 4.2 2.3 micrograms/ml; procainamide, 26.4 27.0 phenytoin, 8.4 6.4 a new beta-blocker, N-696, 7.6 8.7 micrograms/ml. The disopyramide phenytoin almost same...
Despite the importance of prefrontal cortical dopamine in modulating reward, little is known about implication specific subregion cortex opioid reward. We investigated role neurons projecting from ventral tegmental area (VTA) to anterior cingulate (ACG) Microinjection retrograde tracer fluorogold (FG) into ACG revealed several retrogradely labelled cells VTA. The FG-positive reactions were noted both tyrosine hydroxylase (TH)-positive and -negative VTA neurons. released levels its major...