A5016913383- Pain Management and Treatment
- Transcranial Magnetic Stimulation Studies
- Botulinum Toxin and Related Neurological Disorders
- Opioid Use Disorder Treatment
- Pain Mechanisms and Treatments
- Musculoskeletal pain and rehabilitation
- Pain Management and Opioid Use
- Vagus Nerve Stimulation Research
- Antifungal resistance and susceptibility
- Anesthesia and Pain Management
- Fungal Infections and Studies
- Spine and Intervertebral Disc Pathology
- Parasitic Infections and Diagnostics
- Prenatal Substance Exposure Effects
- Neurological disorders and treatments
- Cannabis and Cannabinoid Research
- Thyroid Disorders and Treatments
- Ion Channels and Receptors
- Polyamine Metabolism and Applications
- Enterobacteriaceae and Cronobacter Research
- Monoclonal and Polyclonal Antibodies Research
- Cellular transport and secretion
- Cardiovascular Syncope and Autonomic Disorders
- Phytochemicals and Antioxidant Activities
- Intraoperative Neuromonitoring and Anesthetic Effects
Center for Pain and the Brain
2016-2024
MedVadis Research
2024
Tufts University
2017-2020
Oxford University Press (United Kingdom)
2020
University of North Carolina at Pembroke
2019
Massachusetts General Hospital
2018
Harvard University
2018
Stanford University
2018
Pain and Rehabilitation Medicine
2018
University of Virginia
1996
Importance There are limited efficacious treatments for Alzheimer disease. Objective To assess efficacy and adverse events of donanemab, an antibody designed to clear brain amyloid plaque. Design, Setting, Participants Multicenter (277 medical research centers/hospitals in 8 countries), randomized, double-blind, placebo-controlled, 18-month phase 3 trial that enrolled 1736 participants with early symptomatic disease (mild cognitive impairment/mild dementia) low/medium or high tau pathology...
Many patients with diabetic peripheral neuropathy experience chronic pain and inadequate relief despite best available medical treatments.To determine whether 10-kHz spinal cord stimulation (SCS) improves outcomes for refractory painful (PDN).The prospective, multicenter, open-label SENZA-PDN randomized clinical trial compared conventional management (CMM) SCS plus CMM. Participants PDN 1 year or more to gabapentinoids at least other analgesic class, lower limb intensity of 5 cm on a 10-cm...
To evaluate the long-term efficacy of high-frequency (10 kHz) spinal cord stimulation (SCS) for treating refractory painful diabetic neuropathy (PDN).
Stimulation of murine resident peritoneal cells (RPCs) by encapsulated strain 52 and acapsular 602 Cryptococcus neoformans was compared. Fresh serum required for fungistasis both strains. Encapsulated organisms were killed only if the RPCs activated with gamma interferon (IFN-gamma) or opsonized anticapsular immunoglobulin G (IgG). In contrast, unactivated RPCs, enhanced killing seen IFN-gamma. Except unopsonized 52, all strains phagocytosed. The respiratory burst stimulated in...
Infections with the encapsulated fungus Cryptococcus neoformans are usually acquired via inhalation, and presence of a capsule has been identified as virulence factor. Therefore, we studied murine bronchoalveolar macrophage (BAM)-mediated killing phagocytosis acapsular strains C. neoformans. After 2 h, BAM killed CN52 MP415 more readily than CN602 CAP67 (54.9 36.2% vs 26.1 6.7%, respectively, p less 0.001). Pre-incubating purified capsular polysaccharide increased to 42.7% (p = 0.04)....
Mucin glycoprotein secretion from prairie dog gallbladder explants was studied in 24-h organ culture using [3H]glucosamine as a precursor. Indomethacin caused reversible dose-dependent inhibition of both mucin release (50% between 10(-6) and 10(-5) M indomethacin) 6-ketoprostaglandin F1 alpha (6-keto-PGF1 alpha) (66% at 10(-7) M). Sepharose 4B chromatography secreted [3H]-glucosamine-labeled glycoproteins revealed that indomethacin inhibited high-molecular (greater than 10(6) daltons)...
To evaluate high-frequency (10-kHz) spinal cord stimulation (SCS) treatment in refractory painful diabetic neuropathy.A prospective, multicenter randomized controlled trial was conducted between Aug 28, 2017 and March 16, 2021, comparing conventional medical management (CMM) with 10-kHz SCS+CMM. The participants had hemoglobin A1c level of less than or equal to 10% pain greater 5 10 cm on visual analog scale, neuropathy symptoms 12 months more gabapentinoids at least 1 other analgesic class....
Objective: To evaluate clinical outcomes and health care utilization at 12 months post spinal cord stimulator (SCS) implantation compared with baseline a matched sample of patients receiving conventional medical management (CMM) for the treatment low back lower extremity pain. Patients: A retrospective study least 24 active an interdisciplinary community pain center between December 1, 2014 31, 2017. Thirty-two high-frequency (10 kHz) SCS 64 CMM were identified through propensity matching...
In studies of phagocytosis and its consequences for cell activation, it is important to distinguish those particulate stimuli which are completely ingested internalized from only attached phagocytic surfaces. Ingestion can be profoundly influenced by both the type opsonins on surface stimulus expression activation receptors phagocytes these opsonins. We report a new fluorescent assay facilitates rapid reproducible quantitation versus fully live or dead yeast particles phagocytes. The employs...
Abstract In the brain, thyroid hormone dynamically regulates levels of short-lived plasma membrane protein, type II iodothyronine 5'-deiodinase. cultured astrocytes, thyroxine modulates deiodinase by activating cytoskeletal-plasma interactions that increase rate inactivation enzyme. Here we characterized effects these thyroxine-dependent cytoskeletal upon route internalization following intracellular transit affinity-labeled substrate-binding subunit (p29). Thyroxine rapidly induced and...
Abstract Transient receptor potential ankyrin 1 (TRPA1) is implicated in physiological and pathological nociceptive signaling, but the clinical benefit of TRPA1 antagonists chronic pain not clearly demonstrated. LY3526318 an oral, potent, selective novel antagonist. The Chronic Pain Master Protocol was used to evaluate safety efficacy 3 randomized, placebo-controlled, proof-of-concept studies knee osteoarthritis (OA), low back (CLBP), diabetic peripheral neuropathic (DPNP). Participants were...
Health care providers are likely to see an increase in the concomitant use of cannabis and opioids, particularly with increased liberalization ongoing research into possible role medical marijuana for chronic pain. Recent literature reports a prevalence concurrent ranging from 8.9% 31.8%. The primary aim this study was determine relationship between aberrant drug behaviors noncancer pain patients receiving opioid therapy.Retrospective chart review.Community-based, interdisciplinary...
To determine the relationship between opioid dose change, pain severity, and function in patients with chronic pain.Retrospective cohort study.Community interdisciplinary management practice.A total of 778 prescribed opioids for three or more consecutive months April 1, 2013, March 2015.Changes dose, severity rating, modified Roland Morris Disability Questionnaire score, risk data were extracted from medical records analyzed associations.Two hundred forty-three subjects (31.2%) had an...
To examine the validity of World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0) for assessment function in a community-based sample patients with chronic pain conditions undergoing evaluation opioid therapy.One hundred nine 124 were evaluated therapy program between December 1, 2014 and April 10, 2015, inclusive, at one interdisciplinary management practice. Measures included: demographic data; WHODAS 2.0; modified version Roland Morris Questionnaire (RMDQ-m); Patient...
Background: The SENZA-PDN study evaluated high-frequency 10-kHz spinal cord stimulation (SCS) for the treatment of painful diabetic neuropathy (PDN). Over 24 months, SCS provided sustained pain relief and improved health-related quality life. This report presents additional outcomes from study, focusing on diabetes-related life outcomes. Methods: randomized 216 participants with refractory PDN to receive either conventional medical management (CMM) or plus CMM (10-kHz + CMM), allowing...
To determine the average amount of time required to detect opioid aberrancy based upon varying frequencies urine drug testing (UDT) in a community-based, tertiary care pain management center.This study was retrospective analysis 513 consecutive patients enrolled medication program, receiving chronic therapy between January 1, 2018 and December 31, 2018.Data were extracted from medical records including age at start period, sex, ethnicity, marital status, smoking status. UDT performed each...
Prospective, multicenter, randomized controlled trial (SENZA-PDN) to document the impact of 10-kHz spinal cord stimulation (SCS) on painful diabetic neuropathy (PDN).
INTRODUCTION: Approximately 25% of people with diabetes experience painful diabetic neuropathy (PDN), but conventional medical management (CMM) is ineffective for many patients. We previously presented partial study results showing that high-frequency (10 kHz) spinal cord stimulation (SCS) provides substantial symptom relief. Here we report full through 24-month (24M) follow-up. METHODS: conducted a multicenter RCT to evaluate 10 kHz SCS in PDN Key inclusion criteria were: symptoms = 12M...
Background Oxygen is critical to the prevention of hypoxemia-induced morbidity and mortality; yet, access remains inadequate in most low- middle-income countries despite billions dollars spent over decades increase supply. We present a new method for supplemental oxygen delivery whereby OXFO System (OXFO Corporation, Boston, MA, USA) converts pressurized ambient pressure patient inhalation on demand at fixed concentration across fluctuations respiratory rate or tidal volume. This study’s...