A5086414997- Shoulder Injury and Treatment
- Shoulder and Clavicle Injuries
- Tendon Structure and Treatment
- Bone health and osteoporosis research
- Bone Metabolism and Diseases
- Pelvic and Acetabular Injuries
- Bone fractures and treatments
- MicroRNA in disease regulation
- Bone health and treatments
- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Knee injuries and reconstruction techniques
- Circular RNAs in diseases
- Hip and Femur Fractures
- Liver Disease and Transplantation
- Sports injuries and prevention
- Bone and Joint Diseases
- Total Knee Arthroplasty Outcomes
- Orthopaedic implants and arthroplasty
- Spine and Intervertebral Disc Pathology
- Orthopedic Infections and Treatments
- Hip disorders and treatments
- Iron Metabolism and Disorders
- Hemoglobinopathies and Related Disorders
- Connective tissue disorders research
Herz-Jesu Krankenhaus
2019-2023
Ludwig Boltzmann Institute for Experimental and Clinical Traumatology
2018-2022
Unfallkrankenhaus Meidling
2017-2022
Austrian Cluster for Tissue Regeneration
2019-2022
Medical University of Vienna
2016-2020
Context: Established bone turnover markers do not reflect fracture risk in idiopathic male and premenopausal osteoporosis the role of microRNAs (miRNAs) these patients is currently unclear. miRNAs are a class small non-coding RNAs that regulate gene expression tissue homeostasis. They considered new endocrine regulators with promising potential as biomarkers. Objective: Evaluation circulating miRNA signatures female subjects postmenopausal osteoporotic low-traumatic fractures. Design,...
The assessment of bone quality and the prediction fracture risk in idiopathic osteoporosis (IOP) are complex prospects as mineral density (BMD) turnover markers (BTM) do not indicate fracture-risk. MicroRNAs (miRNAs) promising new biomarkers for diseases, but current understanding biological information contained variability miRNAs is limited. Here, we investigated association between serum-levels 19 miRNA to microstructure histomorphometry based upon biopsies µCT (9.3 μm) scans from 36...
Liver cirrhosis leads to bone loss. To date, information on quality (three-dimensional microarchitecture) and, thus, strength is scarce. We observed decreased at both assessed sites, independent of disease severity. Therefore, all patients should undergo early-stage screening for osteoporosis. Recent studies found low mineral density in cirrhosis, but data microstructure are This study weight-bearing and non-weight-bearing bones with healthy controls. The primary objective was evaluate...
Background: Bone mineral density at the humeral head is reduced in patients with chronic rotator cuff tears. loss associated repair failure after reconstruction. Bisphosphonates (eg, zoledronic acid) increase bone density. Hypothesis: Zoledronic acid improves of and biomechanical properties enthesis reconstruction tears rats. Study Design: Controlled laboratory study. Methods: A total 32 male Sprague-Dawley rats underwent unilateral (left) supraspinatus tenotomy delayed transosseous 3 weeks....
Extracorporeal shockwave therapy is a treatment modality, originally introduced into the clinic as lithotripsie, which has also been successfully used in last two decades non-invasive of delayed or non-healing fractures. Initially, mechanism action was attributed to microfracture-induced repair, but intensive basic research now shown that generates its effect tissue via mechanotransduction. Numerous signal transduction pathways have already demonstrated, their entirety trigger an endogenous...
MicroRNAs regulate bone homeostasis, and circulating microRNAs have been proposed as novel biomarkers. The effect of anti-osteoporotic treatment on has not described in detail. Therefore, we performed a comprehensive analysis microRNA serum levels ovariectomized (OVX) sham-operated (SHAM) rats over 12 weeks antiresorptive or osteoanabolic treatment. Forty-two Sprague Dawley underwent SHAM surgery (n = 10) ovariectomy 32). After 8 weeks, OVX were randomized to with zoledronate 11),...
Background: Characteristics of chronic rotator cuff tears include continuous loss tendon structure as well elasticity, followed by a high failure rate after surgical reconstruction. Several studies have already shown the beneficial effect extracorporeal shockwave therapy (ESWT) on tissue regeneration in pathologies. Hypothesis: ESWT improves biomechanical properties functional shoulder outcomes reconstruction rodents. Study Design: Controlled laboratory study. Methods: After detachment and 3...
Summary Background Patients with hepatic cirrhosis are at increased risk of bone loss. Recent work on areal mineral density has reported contradictory findings. As the assessment microarchitecture is complex, a search was made for correlations new serum markers turnover. Current data sclerostin levels in patients fracture divergent and to date only one study examined cirrhosis. Therefore, aim this evaluate test microarchitecture. Methods This performed 32 recently diagnosed controls. The...
Bone stress injuries are commonly due to repetitive loading, as often described in competitive athletes or military recruits. The underlying pathophysiology of bone is multifactorial. present cross-sectional study investigated (i) cortical and trabecular microstructure well volumetric mineral density subjects with at the tibial diaphysis, measured distal tibia radius by means high-resolution peripheral quantitative computed tomography (CT), (ii) areal using dual-energy X-ray absorptiometry...
Zoledronic acid improves bone microarchitecture and biomechanical properties after chronic rotator cuff repair (RCR) in rats. Besides the positive effects of zoledronic on mineral density microarchitecture, bisphosphonates have skeletal muscle function.
Abstract The primary objective was to compare the intraoperative data assessed by OrthoPilot (Aesculap AG, Tuttlingen, Germany) with postoperative coronal and sagittal long-leg standing radiographs. secondary evaluate influence of sex body mass index (BMI) on accuracy effectiveness implantation knee prosthesis OrthoPilot. We included 75 patients in our investigation. Participants received an e.motion AG) using navigation system. Postoperative anteroposterior lateral radiographs were...
To date there are few studies that have investigated bone mineral density (BMD) and markers of metabolism in patients with thalassemia minor form. None the previous trials presented structure analysis patient populations. We present case a 24-year-old Turkish woman heterozygous beta alpha who sustained low-trauma fracture inferior pubic ramus. Despite normal metabolism, dual X‑ray absorptiometry (DXA) showed decreased areal density. Furthermore, severely reduced parameters volumetric was...
The aim of this study was to investigate the effect extracorporeal shockwave therapy (ESWT) on bone microstructure as well bone-tendon-interface and musculo-tendinous transition zone explain previously shown improved biomechanics in a degenerative rotator cuff tear animal model. This hypothesized that biomechanical improvements related ESWT are result muscle tendon properties.In controlled laboratory unilateral supraspinatus (SSP) detachment performed 48 male Sprague-Dawley rats. After...
Abstract Background This study aimed to investigate whether rodent shoulder specimens fixed in formaldehyde for histological and histomorphometric investigations stained using Lugol’s solution soft tissue visualization by micro-computed tomography (microCT) are still eligible be used bone architecture analysis microCT. Methods In this controlled laboratory study, 11 male Sprague-Dawley rats were used. After sacrifice exarticulation both shoulders of healthy assigned into three groups: (A)...
Supplemental material, DS_10.1177_0363546520926471 for Zoledronic Acid Substantially Improves Bone Microarchitecture and Biomechanical Properties After Rotator Cuff Repair in a Rodent Chronic Defect Model by Jakob E. Schanda, Claudia Keibl, Patrick Heimel, Xavier Monforte, Stefan Tangl, Xaver Feichtinger, Andreas H. Teuschl, Baierl, Christian Muschitz, Heinz Redl, Fialka Rainer Mittermayr The American Journal of Sports Medicine