A5104113860- Osteoarthritis Treatment and Mechanisms
- Diet and metabolism studies
- Traumatic Brain Injury Research
- Gastrointestinal motility and disorders
- Pelvic floor disorders treatments
- Cancer-related molecular mechanisms research
- Hernia repair and management
- Anorectal Disease Treatments and Outcomes
- Folate and B Vitamins Research
- Nutrition and Health in Aging
- GDF15 and Related Biomarkers
- Traumatic Brain Injury and Neurovascular Disturbances
- Gut microbiota and health
- Proteoglycans and glycosaminoglycans research
- Health, psychology, and well-being
- Knee injuries and reconstruction techniques
- Sulfur Compounds in Biology
- Mitochondrial Function and Pathology
- Electrical and Bioimpedance Tomography
- Histone Deacetylase Inhibitors Research
- Winter Sports Injuries and Performance
- Effects of Radiation Exposure
- Neuroscience of respiration and sleep
- Systemic Lupus Erythematosus Research
- S100 Proteins and Annexins
Johns Hopkins University
2020-2025
Saarland University
2024
Anqing City Hospital
2023-2024
National Institute of Nursing Research
2012-2019
National Institutes of Health
2012-2019
United States Department of Health and Human Services
2017
Huzhou University
2017
Wenzhou Medical University
2016
First Affiliated Hospital of Wenzhou Medical University
2016
Nanjing Chest Hospital
2012
Irritable bowel syndrome (IBS) is a poorly understood disorder characterized by persistent symptoms, including visceral pain. Studies have demonstrated oral microbiome differences in inflammatory diseases suggesting the potential of study non-oral conditions.In this exploratory we examine whether exist IBS participants and healthy controls, relates to symptom severity.The buccal mucosal 38 was using PhyloChip microarrays. The severity pain assessed orally administering gastrointestinal test...
Abstract Introduction Laboratory studies suggest an involvement of growth differentiation factor 15 (GDF-15) in metabolic dysregulation. However, the utility GDF-15 for assessing risk cardiometabolic outcomes has not been rigorously examined among older adults. Methods We conducted a cross-sectional analysis adults who attended visit 6 (2016–2017) Atherosclerosis Risk Communities (ARIC) Study. used multivariable logistic regression to quantify associations (in quartiles) with prevalent...
We conducted a prospective study to identify genome-wide changes in peripheral gene expression before and after sports-related concussion (SRC). A total of 253 collegiate contact athletes underwent collection blood mononuclear cells (PBMCs) the sport season (baseline). Sixteen who subsequently developed an SRC, along with 16 non-concussed teammate controls, repeat PBMCs within 6 h injury (acutely). Concussed additional sample at 7 days post-injury (sub-acutely). Messenger RNA (mRNA) baseline...
Stress is known to perturb the microbiome and exacerbate irritable bowel syndrome (IBS) associated symptoms. Characterizing structural functional changes in necessary understand how alterations affect biomolecular environment of gut IBS. Repeated water avoidance (WA) stress was used induce IBS-like symptoms rats. The colon-mucosa characterized 13 stressed control animals by 16S sequencing. In silico analysis domains microbial communities done inferring metagenomic profiles from data....
Approximately one-quarter of military personnel who deployed to combat stations sustained one or more blast-related, closed-head injuries. Blast injuries result from the detonation an explosive device. The mechanisms associated with blast exposure that give rise traumatic brain injury (TBI), and place at high risk for chronic symptoms post-concussive disorder (PCD), post-traumatic stress (PTSD), depression are not elucidated.To investigate persistent blast-related symptoms, we examined...
Older age consistently relates to a lesser ability fully recover from traumatic brain injury (TBI); however, there is limited data explicate the nature of age-related risks. This study was undertaken determine relationship on gene-activity following TBI, and how this biomarker changes in neuroimaging findings. A younger group (between ages 19-35 years), an older 60-89 years) were compared global within 48 hours then at follow-up 1-week. At each time-point gene-expression profiles, imaging...
The aim of this study was to assess the association high-sensitivity cardiac troponin (hs-cTnT) and other cardiac, kidney, hyperglycemia, inflammatory biomarkers with peripheral neuropathy (PN) in a community-based population.We conducted cross-sectional analysis 3056 black white participants Atherosclerosis Risk Communities (ARIC) who underwent standardized monofilament PN testing had measures function (hs-cTnT, N-terminal pro-B-type natriuretic peptide [NT-proBNP], growth differentiation...
A novel multi-channel surface electromyography (EMG)-based three-dimensional muscle activity imaging (MAI) technique has been developed by combining the bioelectrical source reconstruction approach and subject-specific finite element modeling approach. Internal activities are modeled a current density distribution estimated from intra-vaginal EMG signals with aid of weighted minimum norm estimation algorithm. The MAI was employed to minimally invasively reconstruct electrical in pelvic floor...
The aim of the current study was to explore effects and possible mechanisms tripterygium glycosides tablet (TGT) in treatment active ankylosing spondylitis (AS). Thirty‑six patients with AS were given a 20 mg TGT three times per day for 12 weeks, 21 unrelated healthy controls recruited as control group. Efficacy measures included Bath disease activity index (BASDAI), erythrocyte sedimentation rate (ESR) C‑reactive protein (CRP) prior subsequent treatment. Serum dickkopf homolog 1 (DKK1)...
Sleep disturbance is a common and disturbing symptom in military personnel, with many individuals progressing to the development of insomnia, which characterized by increased arousals, wakefulness after sleep onset, distorted architecture. The molecular mechanisms underlying insomnia remain elusive, limiting future therapeutic address this critical issue. We examined whole gene expression profiles associated insomnia. compared subjects ( n = 25) controls 13) without using microarray obtained...
Research examining the role of stress in gastrointestinal (GI) symptoms such as chronic abdominal pain (CAP) is controversial. The purpose this study was to examine expression genes involved metabolic and toxicity men women with high low levels perceived without CAP.Data samples were collected analyzed 26 individuals who had consented participate a natural history protocol. Subjects completed 10-item Perceived Stress scale (PSS). Fasting participants' peripheral whole blood for proteomic...
Background and objective Differences in gene expression may provide insight into the biological pathways involved chronic postsurgical pain (CPSP). We compared blood RNA microarrays preoperatively postoperatively following total knee arthroplasty (TKA) patients with without CPSP. Methods Patients scheduled for primary TKA had whole samples obtained at 48 hours 6 months postsurgery. (54 613 transcripts) were assayed using “Affymetrix HG-U133 plus 2.0” microarray. Genes that met threshold...
This study assesses the efficacy of bilateral mesh sacrospinous ligament suspension (MSSLS) compared to laparoscopic sacrocolpopexy (LSC) in patients with uterine prolapse. Ninety-eight prolapse were evaluated at our hospital from January 2021 2023. Patients equally divided into two groups: group (undergoing MSSLS) and control LSC) using a random number table. Various parameters including operation time, bleeding volume, indwelling catheter exhaust stay, pelvic organ stage, postoperative...
Introduction Maintaining haemodynamic stability is crucial but challenging during the induction and maintenance of general anaesthesia (GA) in patients undergoing off-pump coronary artery bypass grafting (OPCABG). Remimazolam tosylate a novel ultra-short-acting benzodiazepine with minimal cardiovascular depression. Currently, non-inferior studies comparing changes induced by remimazolam etomidate are limited. This study aims to assess efficacy safety for GA OPCABG. Method analysis two-armed...
Despite various available treatments, highly prevalent osteoarthritis cannot be cured in patients. In light of evidence showing mitochondria dysfunction during the disease progression, our goal was to develop a novel therapeutic concept based on transplantation as platforms deliver recombinant adeno-associated viral (rAAV) gene vectors with potency for osteoarthritis. For first time best knowledge, we report successful creation safe mitochondria/rAAV system effectively promoting...
Background & Aims. Intestinal barrier alterations are associated with fatty liver (FL) and metabolic syndrome (MetS), but microRNA (miR) signaling pathways in MetS-FL pathogenesis remain unclear. This study investigates an epithelial-focused miR network colorectal cell models based on the previously reported trio of hsa-miR-142-3p, hsa-miR-18b, hsa-miR-890. Methods. Each mimic construct was transfected into human cells, CRL-1790 or Caco-2. Global miRNome changes posttransfection were...
Abstract Objective The aim in this study was to evaluate the efficacy of mesh bilaterally sacrospinous ligament suspension (MSSLS), as compared with laparoscopic sacrocolpopexy (LSC) patients uterine prolapse. Methods Our evaluated 98 prolapse our hospital from January 2021 2023. Patients enrolled were equally divided into group (treated MSSLS operation) and control LSC by random number table. operation conditions (including time, bleeding volume, indwelling catheter exhaust stay), stage...