A5031595734- Gastrointestinal motility and disorders
- MicroRNA in disease regulation
- Music Therapy and Health
- Gut microbiota and health
- Mobile Health and mHealth Applications
- Health and Well-being Studies
- Diet and metabolism studies
- Health and Wellbeing Research
- Medication Adherence and Compliance
- Cancer-related molecular mechanisms research
- Telemedicine and Telehealth Implementation
- Complementary and Alternative Medicine Studies
- Health, psychology, and well-being
- Healthcare professionals’ stress and burnout
- Adolescent and Pediatric Healthcare
- Digital Mental Health Interventions
- Cardiac Imaging and Diagnostics
- Clinical Nutrition and Gastroenterology
- Gastroesophageal reflux and treatments
- Child and Adolescent Psychosocial and Emotional Development
- Psychosomatic Disorders and Their Treatments
- Infant Health and Development
- Fuel Cells and Related Materials
- Neuroscience and Music Perception
- Pain Management and Placebo Effect
University of Missouri
2017-2024
University College London
2019
Norfolk and Norwich University Hospitals NHS Foundation Trust
2019
University Hospitals of North Midlands NHS Trust
2019
Sheffield Teaching Hospitals NHS Foundation Trust
2019
Gloucestershire Hospitals NHS Foundation Trust
2019
Cambridge University Hospitals NHS Foundation Trust
2019
Royal Marsden NHS Foundation Trust
2019
University College London Hospitals NHS Foundation Trust
2019
National Institute of Nursing Research
2014-2018
To summarize and synthesize current literature on neuroimaging the brain-gut axis in patients with irritable bowel syndrome (IBS).A database search for relevant was conducted using PubMed, Scopus Embase February 2015. Date filters were applied from year 2009 onward, studies limited to those written English language performed upon human subjects. The initial yielded 797 articles, out of which 38 pulled full text review 27 included study analysis. Investigations reviewed determine design,...
Irritable bowel syndrome (IBS) is a poorly understood disorder characterized by persistent symptoms, including visceral pain. Studies have demonstrated oral microbiome differences in inflammatory diseases suggesting the potential of study non-oral conditions.In this exploratory we examine whether exist IBS participants and healthy controls, relates to symptom severity.The buccal mucosal 38 was using PhyloChip microarrays. The severity pain assessed orally administering gastrointestinal test...
Catastrophizing is a cognitive process characterized by propensity to concentrate on and magnify the value of an actual or anticipated painful stimulus negatively assesses one's ability cope. important predictor pain-related outcomes. A cornerstone symptom irritable bowel syndrome (IBS) abdominal pain discomfort. Also individuals with IBS have been reported tendency catastrophize. In sample who suffer from IBS, we hypothesized that those catastrophize (catastrophizers) would worse outcomes...
Stress has demonstrated effects on inflammation though underlying cell-cell communication mechanisms remain unclear. We hypothesize that circulating RNAs and extracellular vesicles (EVs) in patients with chronic stress contain signals functional roles cell repair.Blood transcriptome from Irritable Bowel Syndrome versus controls were compared to identify signaling pathways effectors. Plasma EVs isolated (size-exclusion chromatography) characterized for effectors' presence (immunogold...
There is limited understanding of the influence psychosocial factors on irritable bowel syndrome (IBS), which contributes to management difficulties and ineffective long-term treatment. The goal current study was assess effect illness representations coping had health-related quality life (HRQOL) in adults with IBS. Self-report data were collected from 101 Illness measured Revised Perception Questionnaire; catastrophizing subscale Coping Strategies HRQOL using IBS-Quality Life Measure....
AIM:To investigate the vasoactive intestinal peptides (VIP) expression in irritable bowel syndrome (IBS) and trinitrobenzene sulfonic acid (TNBS) induced colitis. METHODS:The VIP gene protein plasma levels were measured adult participants (45.8% male) who met Rome Ⅲ criteria for IBS longer than 6 mo a rat model of colitis as by TNBS.Plasma colons collected from naïve inflamed rats.Markers assessing inflammation (i.e. , weight changes myeloperoxidase levels) assessed on days 2, 7, 14 28...
Abstract Background IMPORT HIGH is a randomised, multi-centre phase III trial testing dose escalated simultaneous integrated boost (SIB) against sequential each delivered by intensity modulated radiotherapy (IMRT) for early stage breast cancer with higher risk of local relapse. The primary endpoint was initially induration at 3 years, requiring 840 patients; accrual extended (target 2568) the new We report adverse effects (AE) years. Methods Women age ≥18 after conservation surgery pT1-3...
Usability testing has historically been an in-person activity where test participants and evaluation researchers are co-located. Recruiting into usability studies can be a challenging endeavor especially when potential concerned about time commitments social distancing. The global COVID-19 pandemic driven the development of remote methods. In this paper, we describe as it evolved during pre-pandemic research study. We adapted our methodology for commercially available mHealth app to...
Irritable bowel syndrome (IBS) is a common gastrointestinal disorder characterized by abdominal pain and dysfunction in the absence of structural abnormality. Diagnosis can be challenging often leads to extensive medical tests, non-effective therapeutic modalities, reduced quality life (QOL). Identifying factors associated with have potential enhance outcomes. Participants IBS (n = 41) healthy volunteers 74) were recruited into this cross-sectional, descriptive, natural history protocol at...
Abdominal pain is a chronic condition experienced by approximately 20% of individuals in the United States. The purpose study was to assess validity Gastrointestinal Pain Pointer as measure abdominal intensity. A prospective longitudinal time-series design utilized. sample included 93 outpatients (58.1% female). Participants met Rome III criteria for irritable bowel syndrome (n = 32) or were healthy controls 61). Pointer, new electronic assessment tool, used self-reported intensity among...
The gene expression platform assay allows for robust and highly reproducible quantification of the up to 800 transcripts (mRNA or miRNAs) in a single reaction. miRNA counts by directly imaging digitally counting molecules that are labeled with color-coded fluorescent barcoded probe sets (a reporter capture probe). Barcodes hybridized mature miRNAs have been elongated ligating unique oligonucleotide tag (miRtag) 3' end. Reverse transcription amplification not required. Reporter probes contain...
Irritable Bowel Syndrome (IBS), characterized by abdominal pain and bowel dysfunction, treatment focuses on alleviating symptoms. Adherence is crucial for pharmacologic management success. We examined 73 adult’s objective adherence to rifaximin using the taxonomy adherence. Demographic, quality of life (QOL), psychological distress, perceived stress, adverse childhood experiences (ACE), pain, data were collected. Impaired QOL, elevated distress a significant number ACE reported at baseline....
The global COVID-19 pandemic has driven innovations in methods to sustain initiatives for the design, development, evaluation, and implementation of clinical support technology long-term care settings while removing risk infection residents, family members, health workers, researchers technical professionals. We adapted traditional design evaluation methodology a mobile decision app - designated Mobile Application Information System Integrated Evidence ("MAISIE") completely digital that...
Medication adherence is poor in persons with chronic disease, especially those multiple diseases, one of which a psychological disorder. Social support, medication education, and external reminders have been identified as facilitators adherence. Mobile health applications the potential to enhance adherence; however, it unknown if publicly available are user-friendly useful. We aimed examine usability feasibility “MediSafe” reminder application adults diarrhea-predominant irritable bowel...
Introduction: The primary objective of this study was to assess the feasibility a 6-week internet-delivered Mantram Repetition Program (MRP) for women recently treated breast cancer. A secondary explored changes in perceived stress, psycho-spiritual measures, and cytokines treatment group compared waitlist. Methods: (ORBIT model Phase IIa) with randomized controlled trial pilot conducted. Eligible cancer were ( n = 14) or waitlist 12) participated 12 weeks. During weeks 1-6, received MRP...
The aim of this study was to describe the layperson's knowledge and perceptions regarding aetiology, pathogenesis, prevalence, medical evaluation, diagnosis treatment irritable bowel syndrome.Diagnosis acceptance adherence is influenced by views patient's social networks. Little known how these networks influence those with syndrome.Cross-sectional two-hundred four laypersons, ages 18-80 years without an syndrome diagnosis.Data were collected May 2016-March 2017. Laypersons a IBS...
Colonic epithelial health is implicated in a host of gastrointestinal (GI) diseases and disorders. Lysozyme suspected to play role the ability epithelium recover from injury (Abey et al., press; Gallo, 2012; Rubio, 2014) [1], [2], [3]. Disrupted repair mechanisms may lead delayed or ineffective recovery disruptions biology resulting GI symptoms altered barrier function (Peterson Artis, [4]. The effect lysozyme on transcriptomic proteomic profile healthy colonic cells was investigated....
Medication nonadherence is a public health issue that contributes to poor outcomes and health-care costs. Factors influencing long-term medication adherence are known; however, little known about short-course adherence.This study examined patient perspectives on factors influence pharmacotherapy in diarrhea-predominant irritable bowel syndrome.Twenty-seven participants were interviewed identify their perceptions of barriers facilitators thrice-daily, 14-day rifaximin.Participants primarily...