A5028228559- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Osteoarthritis Treatment and Mechanisms
- Orthopedic Infections and Treatments
- Spine and Intervertebral Disc Pathology
- Lower Extremity Biomechanics and Pathologies
- Hip disorders and treatments
- Sports injuries and prevention
- Health disparities and outcomes
- Orthopaedic implants and arthroplasty
- Orthodontics and Dentofacial Orthopedics
- Orthopedic Surgery and Rehabilitation
- Advanced Statistical Methods and Models
- Musculoskeletal pain and rehabilitation
- Tendon Structure and Treatment
- Global Cancer Incidence and Screening
- Foot and Ankle Surgery
- Shoulder Injury and Treatment
- Acute Lymphoblastic Leukemia research
- Cardiovascular Disease and Adiposity
- Temporomandibular Joint Disorders
- Adipose Tissue and Metabolism
- Infectious Diseases and Tuberculosis
- Cardiovascular Effects of Exercise
- Body Composition Measurement Techniques
University of Missouri
2016-2025
University of Missouri Health System
2016-2024
Columbia Orthopaedic Group
2019-2024
University of Missouri Hospital
2023-2024
GTx (United States)
2021
University Physicians
2021
Orthopedic Institute
2021
Ichor Life Sciences (United States)
2018
University of Missouri System
2018
University of Florida
2014-2015
•Understanding vertical facial divergence is critical to treatment optimization.•Growth in 3 types quantified with geometric morphometrics.•Normodivergent and hypodivergent growth are distinct from hyperdivergent growth.•Anteroposterior maxillomandibular restricted patients.•Hyperdivergent patterns indicate a greater risk for Class II malocclusion. IntroductionExtreme of great importance clinicians because their association dental malocclusion functional problems the orofacial complex....
Catastrophizing is a cognitive process characterized by propensity to concentrate on and magnify the value of an actual or anticipated painful stimulus negatively assesses one's ability cope. important predictor pain-related outcomes. A cornerstone symptom irritable bowel syndrome (IBS) abdominal pain discomfort. Also individuals with IBS have been reported tendency catastrophize. In sample who suffer from IBS, we hypothesized that those catastrophize (catastrophizers) would worse outcomes...
Mild stroke comprises 53% of hospital admissions; however, the majority those with mild patients receive little support to address chronic symptoms following stroke.To evaluate feasibility and preliminary effect Chronic Disease Self-Management Program (CDSMP) for use individuals immediately post mild-stroke.Single-blind, exploratory, randomized controlled trial participants who sustained a (NIHSS <6). Participants were either CDSMP intervention or an inactive control group. Primary outcomes...
Background: Supracondylar humerus fractures (SCHFs) are the most common elbow fracture in pediatric population. In case of displaced fractures, closed reduction and percutaneous Kirschner wire pinning (CRPP) is commonly performed. Infection rates between 0 7%; however, retrospective studies have shown no benefit preoperative antibiotics. There continues to be notable variability antibiotic usage based on surgeon preference local institutional policy. We conducted a double-blinded, randomized...
Background: Psychoneuroimmunological theory suggests a physiological relationship exists between stress, psychosocial-behavioral factors, and neuroendocrine-immune outcomes; however, evidence has been limited. Objective: The primary aim of this pilot study was to determine feasibility acceptability salivary cortisol self-collection protocol with mail-back option for breast cancer survivors. A secondary examine relationships religiousness/spirituality (R/S), perceptions health, diurnal (DSC)...
There is limited understanding of the influence psychosocial factors on irritable bowel syndrome (IBS), which contributes to management difficulties and ineffective long-term treatment. The goal current study was assess effect illness representations coping had health-related quality life (HRQOL) in adults with IBS. Self-report data were collected from 101 Illness measured Revised Perception Questionnaire; catastrophizing subscale Coping Strategies HRQOL using IBS-Quality Life Measure....
Limited reports exist regarding adeno-associated virus (AAV) biodistribution in swine. This study assessed following antegrade intracoronary and intravenous delivery of two self-complementary serotype 9 AAV (AAV9sc) biologics designed to target signaling the cardiomyocyte considered important for development heart failure. Under control a cardiomyocyte-specific promoter, AAV9sc.shmAKAP AAV9sc.RBD express small hairpin RNA perinuclear scaffold protein muscle A-kinase anchoring β (mAKAPβ) an...
Effective treatment for bipolar articular cartilage lesions in the knee remains a clinical challenge. Lower extremity malalignment is risk factor failures, which can be addressed by tibial or femoral osteotomy. The purpose of this study was to compare outcomes among patients who underwent joint restoration osteochondral allograft (OCA) transplantation with concurrent staged realignment With Institutional Review Board approval, undergoing OCA distal osteotomy (DFO) high (HTO) were analyzed....
Background Estimates pertaining to the timing of adolescent growth spurt (e.g. peak height velocity; PHV), including age at velocity (aPHV), play a critical role in diagnosis, treatment, and management skeletal and/or developmental disorders. Yet, distinct statistical methodologies often result large estimate discrepancies.Aim The aim present study was assess advantages disadvantages three modelling for as well determine how estimates derived from these may differ, particularly those that be...
Surgical site infections (SSIs) significantly influence outcomes and health care costs after orthopaedic surgery, but they have not been well characterized for osteochondral allograft (OCA) transplantation with or without meniscal (MAT).To characterize the incidence, cost, risk factors associated potential confirmed SSIs large single-surface, multisurface, bipolar in knee.Case-control study; Level of evidence, 3.Prospectively collected registry data were analyzed patients who underwent...
The goal of this study was to objectively examine vocal fold (VF) motion dynamics after iatrogenic recurrent laryngeal nerve (RLN) injury in a mouse surgical model. Furthermore, we sought identify method inducing with consistent recovery pattern from which can begin evaluate spontaneous and test therapeutic interventions.Animal model.The right RLN C57BL/6J mice crushed for 30 seconds using an aneurysm clip 1.3-N closing force. Transoral laryngoscopy enabled visualization VF movement prior...
The revised ALS functional rating scale (ALSFRS-R) is a longitudinal measure of global function commonly used to assess progression amyotrophic lateral sclerosis (ALS), and as an endpoint in clinical trials. Understanding how baseline covariates affect the rate decline offers valuable information trialists. We mixed modeling approach retrospective study pooled resource open-Access trials database elucidate associations between ALSFRS-R over time. In cohort 3203 patients followed for average...
Macular degeneration is hallmarked by retinal accumulation of toxic retinoid species (e.g., A2E) for which there no endogenous mechanism to eliminate it. This ultimately results in progressive dysfunction and loss vision either advanced age genetically normal patients (age-related macular degeneration) or adolescence those with inherited genetic mutations (Stargardt's disease). In this article, we present a proof-of-concept study an enzyme-based therapy remove these retinoids, modeled on...
Abstract Objectives: Determine the relevance of most frequently used patient-reported outcome measures (PROMs) for monitoring patient recovery after ankle fracture, from clinical perspective orthopaedic trauma surgeons, given lack validated PROMs. Design: Prospective cohort. Setting: Orthopaedic Trauma Association committee meetings, electronic correspondence. Patients/Participants: surgeons. Intervention: Delphi method consensus activities. Level Evidence: IV. Main Outcome Measurements:...