A5014696412- Asthma and respiratory diseases
- Veterinary Oncology Research
- Allergic Rhinitis and Sensitization
- Tracheal and airway disorders
- Cardiovascular Conditions and Treatments
- Gut microbiota and health
- Respiratory and Cough-Related Research
- Dysphagia Assessment and Management
- Inhalation and Respiratory Drug Delivery
- Pulmonary Hypertension Research and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Neuropeptides and Animal Physiology
- Mast cells and histamine
- Probiotics and Fermented Foods
- Medical Imaging and Pathology Studies
- Neonatal Respiratory Health Research
- Respiratory Support and Mechanisms
- Respiratory viral infections research
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- Voice and Speech Disorders
- Pediatric health and respiratory diseases
- Gastroesophageal reflux and treatments
- Veterinary Equine Medical Research
- Ultrasound in Clinical Applications
University of Missouri
2016-2025
Missouri College
2016-2025
University of Missouri Health System
2017-2021
Oklahoma State University
2019
University of Veterinary Medicine
2009
North Carolina State University
2008
Veterinary Diagnostics Institute
2008
Columbia University
2007
University of California, Davis
2004-2006
Michigan State University
2006
Pulmonary hypertension (PH), defined by increased pressure within the pulmonary vasculature, is a hemodynamic and pathophysiologic state present in wide variety of cardiovascular, respiratory, systemic diseases. The purpose this consensus statement to provide multidisciplinary approach guidelines for diagnosis, classification, treatment, monitoring PH dogs. Comprehensive evaluation including consideration signalment, clinical signs, echocardiographic parameters, results other diagnostic...
<i>Background:</i> Animal models are used to mimic human asthma, however, not all replicate the major characteristics of disease. Spontaneous development asthma with hallmark features similar humans has been documented occur relative frequency in only one animal species, cat. We hypothesized that we could develop an experimental model feline using clinically relevant aeroallergens identified from cases naturally developing and characterize immunologic, physiologic, pathologic...
Summary Background Mesenchymal stem cells ( MSC s) decrease airway eosinophilia, hyperresponsiveness AHR ), and remodelling in murine models of acutely induced asthma. We hypothesized that s would diminish these hallmark features a chronic feline asthma model. Objective To document effects allogeneic, adipose‐derived on inflammation, , over time investigate mechanisms by which alter local systemic immunologic responses experimental allergic Methods Cats with chronic, experimentally received...
The upper and lower airways of healthy humans are reported to harbor stable consistent bacterial populations, the composition these communities is altered in individuals affected with several respiratory diseases. Data regarding presence airway microbiota other animals scant a better understanding metabolic function such populations essential for development novel therapeutic diagnostic modalities use both veterinary human medicine. Based on targeted next-generation sequencing feces samples...
Advances in the field of metagenomics using culture-independent methods microbial identification have allowed characterization rich and diverse communities bacteria lungs healthy humans, mice, dogs, sheep pigs. These data challenge long held belief that are sterile colonization is synonymous with pathology. Studies humans animals demonstrate differences composition airway microbiota health versus disease suggesting respiratory dysbiosis occurs. Using 16S rRNA amplicon sequencing DNA...
The aim of this study was to evaluate the feasibility and efficacy serially administered adipose-derived mesenchymal stem cells (MSCs) in an experimental feline asthma model.
Abstract OBJECTIVE To document differences in the microbiota of healthy cats versus with urethral obstruction (UO); compare urinary oral, preputial, and rectal microbiota; demonstrate that 16S rRNA gene sequencing will reveal rich diverse microbiota. METHODS 15 client-owned UO age-matched were included from July 2020 through April 2021. Exclusion criteria evidence tract infection, urolithiasis, antimicrobial administration, catheterization past 30 days, or a comorbidity. This study was...
Abstract Objective To compare pulmonary arterial remodeling in cats with histopathologic diagnosis of bronchiolar disorder (BD) to control without BD. Methods Lung tissue from primary or secondary BD (n = 13) were compared histopathological evidence and cardiac disease 13). Wall-to-lumen ratio scores, wall cross-sectional area, intimal, medial, adventitial tunic areas between groups for small (70 300 μm), medium (301 999 large (≥ 1,000 µm) arteries. Analysis used linear mixed models γ-log...
Abstract Objective —To evaluate assessment of circulating amino terminal-pro-B-type natriuretic peptide (NT-proBNP) concentration as a means to discriminate between congestive heart failure and primary pulmonary disease in dogs. Design —Prospective case series. Animals —46 dogs with signs respiratory distress or coughing. Procedures —All underwent physical thoracic radiographic examinations. Dogs evidence (eg, murmur, arrhythmia, large cardiac silhouette detected by radiography) also...
State-of-the-art health care includes genome sequencing of the patient to identify genetic variants that contribute either cause their malady or can be targeted improve treatment. The goal was introduce state-of-the-art cats using genomics and a precision medicine approach. To test feasibility approach in domestic cats, single cat presented University Missouri, Veterinary Health Center with an undiagnosed neurologic disease whole-genome sequenced. DNA from were compared variant database...
Abstract Spontaneous cancers in companion dogs are robust models of human disease. Tracking tumor-specific immune responses these requires reagents to perform species-specific single cell T receptor sequencing (scTCRseq). scTCRseq and integration with scRNA data have not been demonstrated on cancer. Here, five healthy dogs, two lymphoma four melanoma selected demonstrate applicability a cancer immunotherapy setting. Single-cell suspensions PBMCs or lymph node aspirates profiled using...
Abstract Objective —To compare the effects of an orally administered corticosteroid (prednisone), inhaled (flunisolide), a leukotriene-receptor antagonist (zafirlukast), antiserotonergic drug (cyproheptadine), and control substance on asthmatic phenotype in cats with experimentally induced asthma. Animals —6 asthma by use Bermuda grass allergen (BGA). Procedures —A randomized, crossover design was used to assess changes percentage eosinophils bronchoalveolar lavage fluid (BALF); airway...
Cats with inflammatory bronchial disease are usually treated glucocorticoid (GC) drugs to reduce airway inflammation. Inhalant GC delivery can preserve effects while systemic minimized. An appropriate dosage regimen for inhaled in cats has not been investigated. A blinded, randomized, cross-over study design was used investigate the ability of three different dosages inhalant fluticasone propionate delivered by metered dose inhaler ameliorate eosinophilic inflammation experimentally induced...
To compare concentrations of interleukin (IL)-4, interferon (IFN)-gamma, tumor necrosis factor (TNF)-alpha and total nitric oxide (NO) metabolites in bronchoalveolar lavage fluid (BALF) for discrimination between asthma chronic bronchitis cats.97 cats.Cats screened with cytologic examination BALF included 13 client-owned cats naturally developing asthma, 8 bronchitis, 23 research experimentally induced 33 nonseptic suppurative inflammation the airways, 20 healthy control cats. Banked...
<i>Background:</i> Blockade of tyrosine kinase signaling by masitinib, a c-kit/PDGF receptor inhibitor, can modulate allergic airway inflammation, but effects on lung mechanics have not been well characterized. We hypothesized masitinib would decrease eosinophilia and consequently improve pulmonary in feline asthma model. <i>Methods:</i> Asthma was induced 12 cats using Bermuda grass allergen (BGA). Cats received 50 mg/day oral or placebo. Bronchoalveolar lavage fluid...
Videofluoroscopic swallow study (VFSS) is the gold standard for diagnosis of dysphagia in veterinary medicine but lacks standardized protocols that emulate physiologic feeding practices. Age impacts function humans has not been evaluated by VFSS dogs.To develop a protocol with custom kennels designed to allow free-feeding 3 optimized formulations contrast media and diets address limitations current protocols. We hypothesized dogs would show differences objective metrics based on age.Healthy...
Probiotics have been advocated as a novel therapeutic approach to respiratory disease, but knowledge of how oral administration probiotics influences the microbiota is needed. Using 16S rRNA amplicon sequencing bacterial DNA our objective was determine whether changed composition upper and lower airway, rectal, blood microbiota. We hypothesized that would modulate in healthy cats, demonstrated by detection and/or increased relative abundance probiotic species altered microbial population...