A5056594389- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Virus-based gene therapy research
- Mesenchymal stem cell research
- RNA Interference and Gene Delivery
- Periodontal Regeneration and Treatments
- Total Knee Arthroplasty Outcomes
- Tendon Structure and Treatment
- Lower Extremity Biomechanics and Pathologies
- Silk-based biomaterials and applications
- Bone and Joint Diseases
- Proteoglycans and glycosaminoglycans research
- Cell Adhesion Molecules Research
- Viral Infectious Diseases and Gene Expression in Insects
- Cancer-related molecular mechanisms research
- Viral Infections and Immunology Research
- Extracellular vesicles in disease
- Electrospun Nanofibers in Biomedical Applications
- Advanced biosensing and bioanalysis techniques
- Hip disorders and treatments
- Bone Tissue Engineering Materials
- Shoulder Injury and Treatment
- interferon and immune responses
- Bone health and treatments
- Nanoplatforms for cancer theranostics
Saarland University
2016-2025
Universitätsklinikum des Saarlandes
2006-2023
Université Sorbonne Paris Nord
2021-2023
Sorbonne Paris Cité
2023
Université Paris Cité
2023
AO Foundation
2013-2021
Sorbonne Université
2021
University of Washington
2019
University Medical Center
2016
University Hospital and Clinics
2016
Bioprinting offers tremendous potential in the fabrication of functional tissue constructs for replacement damaged or diseased tissues. Among other methods used engineering, bioprinting provides accurate control over construct's geometric and compositional attributes using an automated approach. Bioinks are composed hydrogel material living cells that critical process variables functional, mechanically robust constructs. Appropriate can be encapsulated bioinks to create structures. Ideal...
CD8+ T lymphocytes play a major role in antiviral immune defense. Their significance for acute hepatitis C is unclear. Our aim was to correlate the cell response with outcome of infection. Eighteen patients and 19 normal donors were studied. Hepatitis virus (HCV)—specific cells identified enzyme-linked immunospot assay by their interferon-γ (IFN-γ) production after specific stimulation. The highest numbers IFN-γ—producing HCV-specific found self-limited course disease during first 6 months...
Advanced biomaterial-guided delivery of gene vectors is an emerging and highly attractive therapeutic solution for targeted articular cartilage repair, allowing a controlled minimally invasive in spatiotemporally precise manner, reducing intra-articular vector spread possible loss the product. As far as it known, very first successful vivo application such potent orthotopic large animal model damage reported here. In detail, injectable thermosensitive hydrogel based on poly(ethylene oxide)...
Background: Subchondral drilling is an established marrow stimulation technique. Hypothesis: Osteochondral repair improved when the subchondral bone perforated with small drill holes, reflecting physiological trabecular distance. Study Design: Controlled laboratory study. Methods: A rectangular full-thickness chondral defect was created in trochlea of adult sheep (n = 13) and treated 6 drillings either 1.0 mm (reflective distance) or 1.8 diameter. assessed after months vivo by macroscopic,...
Abstract Introduction Transplantation of genetically modified human bone marrow-derived mesenchymal stem cells (hMSCs) with an accurate potential for chondrogenic differentiation may be a powerful means to enhance the healing articular cartilage lesions in patients. Here, we evaluated benefits delivering SOX9 (a key regulator chondrocyte and formation) via safe, maintained, replication-defective recombinant adeno-associated virus (rAAV) vector on capability hMSCs commit adequate phenotype...
Background: Marrow stimulation techniques such as subchondral drilling are clinically important treatment options for symptomatic small cartilage defects. Little is known about whether they induce deleterious changes in the bone. Hypothesis: Subchondral induces substantial alterations of microarchitecture bone that persist a relevant postoperative period preclinical large animal model. Study Design: Controlled laboratory study. Methods: Standardized full-thickness chondral defects medial...
Osteoarthritis (OA) is a prevalent, disabling disorder of the joints that affects large population worldwide and for which there no definitive cure. This review provides critical insights into basic knowledge on OA may lead to innovative end efficient new therapeutic regimens. While degradation articular cartilage hallmark OA, with altered interactions between chondrocytes compounds extracellular matrix, subchondral bone has been also described as key component disease, involving specific...
Abstract The regeneration of focal articular cartilage defects is complicated by the reduced quality repair tissue and potential development perifocal osteoarthritis (OA). Biomaterial‐guided gene therapy may enhance controlling release therapeutic sequences in a spatiotemporal manner. Here, benefits delivering recombinant adeno‐associated virus (rAAV) vector coding for human insulin‐like growth factor I (IGF‐I) via an alginate hydrogel (IGF‐I/AlgPH155) to full‐thickness chondral following...