A5053307665- Stroke Rehabilitation and Recovery
- Acute Ischemic Stroke Management
- Cerebrovascular and Carotid Artery Diseases
- Telemedicine and Telehealth Implementation
- Transcranial Magnetic Stimulation Studies
- Botulinum Toxin and Related Neurological Disorders
- Amyotrophic Lateral Sclerosis Research
- EEG and Brain-Computer Interfaces
- Vasculitis and related conditions
- Intracranial Aneurysms: Treatment and Complications
- Neurological disorders and treatments
- Neuroscience and Neuropharmacology Research
- Epilepsy research and treatment
- Neurogenesis and neuroplasticity mechanisms
- Traumatic Brain Injury and Neurovascular Disturbances
- Cerebral Palsy and Movement Disorders
- Cancer, Hypoxia, and Metabolism
- Neurotransmitter Receptor Influence on Behavior
- Zebrafish Biomedical Research Applications
- Angiogenesis and VEGF in Cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurological Complications and Syndromes
- Cerebral Venous Sinus Thrombosis
- Optical Imaging and Spectroscopy Techniques
- Retinal and Optic Conditions
Johns Hopkins University
2013-2024
Johns Hopkins Medicine
2011-2024
CVPath Institute
2024
University of Maryland, Baltimore
2024
Cedars-Sinai Medical Center
2024
Johns Hopkins Hospital
2010-2023
University of Baltimore
2021
Cleveland Clinic
2021
Phipps Houses
2019
Duke University
2015
Brain-derived neurotrophic factor (BDNF) is thought to be involved in neuronal survival, migration, morphological and biochemical differentiation, modulation of synaptic function the CNS. In rodent cortex, postnatal BDNF expression initially low but subsequently increases reach maximal levels around weaning. Thus, peaks at a time when both structural functional maturation cortical circuitry occurs. Although has been probed using many approaches, its requirements during this phase life have...
To characterize intracranial plaque inflammation in vivo by using three-dimensional (3D) high-spatial-resolution contrast material-enhanced black-blood (BB) magnetic resonance (MR) imaging and to investigate the relationship between cerebrovascular ischemic events.The study was approved institutional review board HIPAA compliant. Twenty-seven patients (19 men; mean age, 56.8 years ± 12.4 [standard deviation]) with events (acute stroke, n = 20; subacute 2; chronic 3; transient attack, 2)...
Background and Purpose— Preliminary studies suggest that intracranial arteries are capable of accommodating plaque formation by remodeling. We sought to study the ability extent remodel using 3-dimensional high-resolution black blood magnetic resonance imaging investigate its relation ischemic events. Methods— Forty-two patients with cerebrovascular events underwent time-of-flight angiography contrast-enhanced examinations at 3 T for atherosclerotic disease. Each was classified location (eg,...
Answer ALS is a biological and clinical resource of patient-derived, induced pluripotent stem (iPS) cell lines, multi-omic data derived from iPS neurons longitudinal smartphone over 1,000 patients with ALS. This provides population-level that may be employed to identify clinical-molecular-biochemical subtypes amyotrophic lateral sclerosis (ALS). A unique smartphone-based system was collect deep data, including fine motor activity, speech, breathing linguistics/cognition. The spinal were...
Pathologic studies suggest that neovascularization and hemorrhage are important features of plaque vulnerability for disruption. Our aim was to determine the associations these in carotid plaques with previous cerebrovascular ischemic events by using high-resolution CE-MRI.Forty-seven patients (36 men; mean age 72.5 ± 10 years) underwent CE-MRI MRA examinations at 3T. IPH presence recorded. Neovascularity categorized degree adventitial enhancement (0, absent; 1, <50%; 2, ≥50%). Reader...
Background and objective. Prior studies have suggested that after stroke there is a time-limited period of increased responsiveness to training as result heightened plasticity—a sensitive thought be induced by ischemia itself. Using mouse model, we previously shown most training-associated recovery caudal forelimb area (CFA) occurs in the first week attributable reorganization medial premotor (AGm). The existence stroke-induced leads counterintuitive prediction second should reopen this...
Background and Purpose— Motor recovery after ischemic stroke in primary motor cortex is thought to occur part through training-enhanced reorganization undamaged premotor areas, enabled by reductions cortical inhibition. Here we used a mouse model of focal double-lesion approach test the idea that medial area (medial agranular [AGm]) reorganizes mediate prehension, this associated with reduction inhibitory interneuron markers. Methods— C57Bl/6 mice were trained perform skilled prehension task...
Background and Purpose— Data from both humans animal models suggest that most recovery motor impairment after stroke occurs in a sensitive period lasts only weeks is mediated, part, by an increased responsiveness to training. Here, we used mouse model of focal cortical test 2 hypotheses. First, investigated whether training decreases over time stroke. Second, tested fluoxetine, which can influence synaptic plasticity recovery, prolong the large training-related gains be elicited Methods—...
Background Evidence from animal studies suggests that greater reductions in poststroke motor impairment can be attained with significantly higher doses and intensities of therapy focused on movement quality. These also indicate a dose-timing interaction, more pronounced effects if high-intensity is delivered the acute/subacute, rather than chronic, period. Objective To compare 2 approaches delivering high-intensity, high-dose upper-limb patients subacute stroke: novel exploratory...
Cerebral ischemia and reperfusion initiate cellular events in brain that lead to neurological disability. Investigating these provides ample targets for developing new treatments. Despite considerable work, no such therapy has translated into successful stroke treatment. Among other issues—such as incomplete mechanistic knowledge faulty clinical trial design—a key contributor prior translational failures may be insufficient scientific rigor during preclinical assessment: nonblinded outcome...
Abstract The clinical presentation of amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease, varies widely across patients, making it challenging to determine if potential therapeutics slow progression. We sought whether there were common patterns disease progression that could aid in the design and analysis trials. developed an approach based on mixture Gaussian processes identify clusters patients sharing similar patterns, modeling their average trajectories variability...
<h3>SUMMARY:</h3> Central nervous system vasculitides are elusive diseases that challenging to diagnose because brain biopsies have high false-negative rates. We sought test the ability of contrast-enhanced, high-resolution 3D vessel wall MR imaging identify vascular inflammation and direct open intracranial target vessels adjacent parenchyma. Eight 9 specimens revealed inflammation. conclude can inflamed vessels, enabling precise localization biopsy targets.
Amyotrophic Lateral Sclerosis (ALS), like many other neurodegenerative diseases, is highly heritable, but with only a small fraction of cases explained by monogenic disease alleles. To better understand sporadic ALS, we report epigenomic profiles, as measured ATAC-seq, motor neuron cultures derived from diverse group 380 ALS patients and 80 healthy controls. We find that chromatin accessibility heavily influenced sex, the iPSC cell type origin, ancestry, inherent variance arising sequencing....
The standard treatment for invasive bladder cancer is radical cystectomy. In selected patients, bladder-sparing therapy can be performed by transurethral resection (TURBT) and radio-chemotherapy (RCT) or radiotherapy (RT). Our published in vitro data suggest that the Neuropilin-2 (NRP2)/VEGF-C axis plays a role resistance. Therefore, we studied prognostic impact of NRP2 VEGF-C 247 patients (cN0M0) treated with TURBT RCT (n = 198) RT 49) follow-up time up to 15 years. A tissue microarray was...
Stimulus-induced rhythmic, periodic, or ictal discharges (SIRPIDs) are a recently described form of epileptiform periodic evoked by arousal. Similar to other (e.g., pseudoperiodic lateralized discharges, generalized bilaterally independent discharges), SIRPIDs lie somewhere along an ictal-interictal continuum. To determine whether represent phenomenon reflected increased focal cerebral perfusion on single-photon emission computerized tomography, conversely interictal pattern, the authors...
Transverse sinus thrombosis can have nonspecific clinical and radiographic signs. We hypothesized that the novel "sigmoid notch sign" (on head CT) help differentiate transverse from a congenitally atretic among individuals with absent signal in 1 by MR venography.We retrospectively evaluated 53 subjects unilaterally on venography. Eleven had true 42 an sinus. Reviewers were trained sigmoid sign: "positive" if of notches was asymmetrically smaller than other, consistent side. This sign scored...
Background Up to 25% of acute stroke patients first note symptoms upon awakening. We hypothesized that awaking with may be safely treated intravenous alteplase (IV tPA) using non-contrast head CT (NCHCT), if they meet all other standard criteria. Methods The SAfety Intravenous thromboLytics in ON awakening (SAIL ON) was a prospective, open-label, single treatment arm, pilot safety trial dose IV tPA who presented within 0–4.5 hours From January 30, 2013, September 1, 2015, twenty consecutive...
Abstract Objective: Perinatal ischemic stroke is estimated to occur in 1/2300–1/5000 live births, but early differential diagnosis from global hypoxia-ischemia often difficult. In this study, we tested the ability of a hand-held transcranial photoacoustic (PA) imaging probe non-invasively detect focal photothrombotic (PTS) within 2 h onset gyrencephalic piglet brain. Approach: About 17 lesions approximately 1 cm area were introduced randomly anterior or posterior cortex via light/dye PTS...
Background. Peripheral nerve injury leads to changes in neuronal activity the contralateral and ipsilateral primary somatosensory cortices (S1), which may lead enduring sensory dysfunction pain. Plasticity barrel visual has been shown occur a layer-specific manner. However, little is known about layer specific associated with limb injury. Objective. To determine short-term plasticity induced by peripheral rat. Methods. In vivo electrophysiology recordings (multiunit local field potential)...