Connie New
A5085536944- Lung Cancer Treatments and Mutations
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Protist diversity and phylogeny
- Cancer Immunotherapy and Biomarkers
- Neurogenetic and Muscular Disorders Research
- Amyotrophic Lateral Sclerosis Research
- Chromosomal and Genetic Variations
- Microtubule and mitosis dynamics
Massachusetts Institute of Technology
2023-2024
Albert Einstein College of Medicine
1991
Loss-of-function mutations in
Amyotrophic Lateral Sclerosis (ALS), like many other neurodegenerative diseases, is highly heritable, but with only a small fraction of cases explained by monogenic disease alleles. To better understand sporadic ALS, we report epigenomic profiles, as measured ATAC-seq, motor neuron cultures derived from diverse group 380 ALS patients and 80 healthy controls. We find that chromatin accessibility heavily influenced sex, the iPSC cell type origin, ancestry, inherent variance arising sequencing....
Abstract The l(1)TW-6cs mutation is a cold-sensitive recessive lethal in Drosophila melanogaster, that affects both meiotic and mitotic chromosome segregation. We report the isolation of three revertants this mutation. All revert effects as well cold sensitivity, demonstrating all phenotypes are due to single lesion. further show these fail complement an amorphic allele nod (no distributive disjunction) locus, which encodes kinesin-like protein. These experiments demonstrate antimorphic nod,...
Abstract Loss-of-function mutations in KEAP1 frequently occur lung cancer and are associated with resistance to standard of care treatment, highlighting the need for development targeted therapies. We have previously shown that mutant tumors increased glutamine consumption support metabolic rewiring NRF2 activation. Here, using patient-derived xenograft models antigenic orthotopic models, we show novel antagonist DRP-104 impairs growth tumors. find suppresses tumor by inhibiting...