A5081513162- Stroke Rehabilitation and Recovery
- Botulinum Toxin and Related Neurological Disorders
- Cerebral Palsy and Movement Disorders
- Acute Ischemic Stroke Management
- Muscle activation and electromyography studies
- Musculoskeletal pain and rehabilitation
- Balance, Gait, and Falls Prevention
- Motor Control and Adaptation
- Linguistics and Cultural Studies
- Neurological Disorders and Treatments
- Health and Medical Studies
- Diabetic Foot Ulcer Assessment and Management
- Long-Term Effects of COVID-19
- Linguistic research and analysis
- EEG and Brain-Computer Interfaces
- Medical Practices and Rehabilitation
- Linguistics and language evolution
- Agriculture Sustainability and Environmental Impact
- Child Nutrition and Water Access
- Nutrition, Genetics, and Disease
- Advanced Electron Microscopy Techniques and Applications
- Thermoregulation and physiological responses
- Social Policies and Healthcare Reform
- Protein Hydrolysis and Bioactive Peptides
- Indigenous Health and Education
UCLA Health
2025
Nova Southeastern University
2025
University of Cincinnati
2025
Barry University
2025
University of California, Los Angeles
2024-2025
University Hospital of Zurich
2020-2024
University of Zurich
2019-2024
University of Twente
2019-2021
Cereneo
2019-2020
Medizinische Hochschule Hannover
2012
Precise and objective assessments of upper limb movement quality after strokes in functional task conditions are an important prerequisite to improve understanding the pathophysiology deficits prove effectiveness interventions. Herein, a wearable inertial sensing system was used capture movements from fingers trunk 10 chronic stroke subjects when performing reach-to-grasp activities with affected non-affected limb. It investigated whether factors, tested arm, object weight, target height,...
Background Evidence from animal studies suggests that greater reductions in poststroke motor impairment can be attained with significantly higher doses and intensities of therapy focused on movement quality. These also indicate a dose-timing interaction, more pronounced effects if high-intensity is delivered the acute/subacute, rather than chronic, period. Objective To compare 2 approaches delivering high-intensity, high-dose upper-limb patients subacute stroke: novel exploratory...
Abstract Digital health metrics promise to advance the understanding of impaired body functions, for example in neurological disorders. However, their clinical integration is challenged by an insufficient validation many existing and often abstract metrics. Here, we propose a data-driven framework select validate clinically relevant core set digital extracted from technology-aided assessment. As exemplary use-case, applied Virtual Peg Insertion Test (VPIT), assessment upper limb sensorimotor...
Background: Deficits in interjoint coordination, such as the inability to move out of synergy, are frequent symptoms stroke subjects with upper limb impairments that hinder them from regaining normal motor function. Kinematic measurements allow a fine-grained assessment movement pathologies, thereby complementing clinical scales, like Fugl–Meyer Motor Assessment Upper Extremity (FMMA-UE). The study goal was investigate effects performed task, tested arm, dominant affected hand, function, and...
Abstract Background Shedding light on the neuroscientific mechanisms of human upper limb motor control, in both healthy and disease conditions (e.g., after a stroke), can help to devise effective tools for quantitative evaluation impaired conditions, properly inform rehabilitative process. Furthermore, design control mechatronic devices also benefit from such outcomes, with important implications assistive rehabilitation robotics advanced human-machine interaction. To reach these goals, we...
Upper limb kinematic assessments provide quantifiable information on qualitative movement behavior and limitations after stroke. A comprehensive characterization of spatiotemporal kinematics stroke subjects during upper daily living activities is lacking. Herein, expressions were investigated with respect to different types impairment levels for the entire task as well motion subphases.Chronic impairments healthy performed a set including gesture grasp movements. Kinematic measures trunk...
The restoration of gait and mobility after stroke is an important challenging therapy goal due to the complexity potentially impaired functions. As a result, precise clinically feasible assessment methods are required for personalized rehabilitation stroke. aim this study investigate reliability validity sensor-based analysis system in survivors with different severities deficits. For purpose, 28 chronic (9 women, ages: 62.04 ± 11.68 years) mild moderate walking impairments performed set...
Introduction Clinical assessment of upper limb sensorimotor function post-stroke is often constrained by low sensitivity and limited information on movement quality. To address this gap, recent studies proposed a standardized instrumented drinking task, as representative daily activity combining different components functional arm use. Although kinematic quality measures for task are well-established, optical motion capture (OMC) has proven effective in their measurement, its clinical...
This study aimed to evaluate the effect of rapid weight regain on fight outcomes in professional mixed martial arts (MMA) athletes competing Bellator. Twenty fighters (16 male and four female fighters) were included analysis. Official weigh-in fight-night weights recorded, percentage was calculated. Fighters divided into groups based their (<10% vs. ≥10%). Descriptive statistics calculated, independent t-tests logistic regression employed. The results indicated that while significantly...
Introduction: Strokes lead to acute deficits with wide-ranging severity. Genetic variation may explain some of these inter-subject differences. The current report examined the relationship that candidate genetic variants have injury and behavioral deficits. We hypothesized known be associated poorer stroke recovery would also more a severe presentation. Methods: Infarcts were outlined on clinical scans acquired during admission as part STRONG (“Stroke, sTress, RehabilitatiON, Genetics”)...
Introduction: Restorative therapies have maximal impact when introduced early post-stroke. Dopamine modulates learning and plasticity, its levels decrease after stroke, making it a key therapeutic candidate. For restorative therapy to promote experience-dependent concomitant training is needed must be provided experimentally given low rehabilitation doses received with usual care (UC); here this was using an established telerehabilitation (TR) system. Current hypotheses : [H1] Adding...
Background: Cognitive factors influence motor performance, but often this is not considered when testing function. Here we examined issue using 3 versions of the Box and Blocks Test (BBT), a measure arm First, developed 2 new, briefer BBT then tested their validity. Second, hypothesized that cognitive would be more strongly related to require longer period testing. Methods: In 71 patients <=30 days post-stroke, were scored. BBT60 standard one; subjects move as many blocks possible over...
Introduction: Neuroplasticity is highest during the first weeks after stroke and can be studied at bedside using EEG. However, brain mapping studies this time are uncommon longitudinal data spaced or months apart, which insufficient to capture neuroplasticity respond therapeutically. Towards goal, a study of frequent EEG was performed in subacute patients deeply understand period. Methods: Post-stroke were included 16 days onset seen four times every 2.1±0.3 (n=2). They paretic hand grip...
Introduction The Fugl-Meyer Motor Assessment (FMMA) is recommended for evaluating stroke motor recovery in clinical practice and research. However, its widespread use requires refined reliability data, particularly across different health professions. We therefore investigated the interrater of FMMA scored by a physical therapist physician using video recordings patients. Methods videos 50 individuals 3 months post (28 females, mean age 71.64 years, median National Institutes Health Stroke...
Abstract Background Assessing arm and hand sensorimotor impairments that are functionally relevant is essential to optimize the impact of neurorehabilitation interventions. Technology-aided assessments should provide a sensitive objective characterization upper limb impairments, but often weight support neglect importance hand, thereby questioning their functional relevance. The Virtual Peg Insertion Test (VPIT) addresses these limitations by quantifying movements as well grip forces during...
The accurate assessment of upper limb motion impairment induced by stroke - which represents one the primary causes disability world-wide is first step to successfully monitor and guide patients' recovery. As today, majority procedures relies on clinical scales, are mostly based ordinal scaling, operator-dependent, subject floor ceiling effects. In this work, we intend overcome these limitations proposing a novel approach analytically evaluate level pathological movement coupling,...
Introduction: Robot-assisted neurorehabilitation is becoming an established method to complement conventional therapy after stroke and provide intensive regimes in unsupervised settings (e.g., home rehabilitation). Intensive therapies may temporarily contribute increasing muscle tone spasticity, especially patients presenting alterations. If sustained without supervision, such increase could have negative effects functional disability, pain). We propose online perturbation-based that...
Rationale: Novel therapeutic approaches are needed in stroke recovery. Whether pharmacological therapies beneficial for enhancing recovery is unclear. Dopamine a neurotransmitter involved motor learning, reward, and brain plasticity. Its prodrug levodopa promising agent Aim hypothesis: To investigate the hypothesis that levodopa, addition to standardized rehabilitation therapy based on active task training, results an enhancement of functional acute ischemic or hemorrhagic patients compared...
Background Autoregulation of the cerebral vasculature keeps brain perfusion stable over a range systemic mean arterial pressures to ensure functioning, e.g., in different body positions. Verticalization, i.e., transfer from lying (0°) upright (70°), which causes blood pressure drop, would otherwise dramatically lower inducing fainting. Understanding autoregulation is therefore prerequisite safe mobilization patients therapy. Aim We measured impact verticalization on flow velocity (CBFV) and...
Vagus nerve stimulation (VNS) paired with rehabilitation therapy improved motor status compared to alone in the phase III VNS-REHAB stroke trial, but treatment response was variable and not associated any clinical measures acquired at baseline, such as age or side of paresis. We hypothesized that neuroimaging would be treatment-related gains, examining performance regional injury versus global brain health parallel measures. Baseline magnetic resonance imaging (MRI) scans trial were used...
ABSTRACT Background Evidence from animal studies suggests that greater reductions in post-stroke motor impairment can be attained with significantly higher doses and intensities of therapy focused on movement quality. These also indicate a dose-timing interaction, more pronounced effects if high-intensity is delivered the acute/subacute, rather than chronic, period. Objective To compare two approaches delivering high-intensity, high-dose upper limb patients subacute stroke: novel exploratory...
Der Pretest eines Patientenfragebogens zur Evaluation teilstationärer Rehabilitation, bei dem insbesondere die Eigenschaften der Subskala "körperliche Funktionsfähigkeit" aus SF-36 und des Funktionsfragebogens Hannover (FFbH) interessierten, ergab Anlass zu einer vertieften Validitätsprüfung beider Instrumente. In einem erweiterten wurden deshalb 520 erwachsene Patienten (Rücklaufquote: 76 %), vor durchschnittlich 16 Monaten eine stationäre orthopädische Rehabilitation nach Hüft- oder...