A5061772385- Genetic Associations and Epidemiology
- Nutrition, Genetics, and Disease
- Genetic Mapping and Diversity in Plants and Animals
- Bioinformatics and Genomic Networks
- Cancer Risks and Factors
- Genetic and phenotypic traits in livestock
- Metabolism, Diabetes, and Cancer
- Cancer, Lipids, and Metabolism
- Liver Disease Diagnosis and Treatment
- Gene expression and cancer classification
- Growth Hormone and Insulin-like Growth Factors
- Migraine and Headache Studies
- Metabolomics and Mass Spectrometry Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Ferroptosis and cancer prognosis
- Corneal surgery and disorders
- DNA Repair Mechanisms
- Genetic Neurodegenerative Diseases
- Genomic variations and chromosomal abnormalities
- Cancer-related molecular mechanisms research
- RNA and protein synthesis mechanisms
- Genetics and Plant Breeding
- Estrogen and related hormone effects
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
University of California, Los Angeles
2016-2025
Cancer Center of Hawaii
2020
University of Hawaiʻi at Mānoa
2020
University of Hawaii System
2020
Texas Biomedical Research Institute
2014
Stanford University
1996-2014
North Carolina State University
2013-2014
Brown University
2014
University of Washington
2014
Fred Hutch Cancer Center
2014
Abstract Motivation: In ordinary regression, imposition of a lasso penalty makes continuous model selection straightforward. Lasso penalized regression is particularly advantageous when the number predictors far exceeds observations. Method: The present article evaluates performance logistic in case–control disease gene mapping with large SNPs (single nucleotide polymorphisms) predictors. strength can be tuned to select predetermined most relevant and other For given value tuning constant,...
Down syndrome (DS), or trisomy 21, is a common disorder associated with several complex clinical phenotypes. Although hypotheses have been put forward, it unclear as to whether particular gene loci on chromosome 21 (HSA21) are sufficient cause DS and its features. Here we present high-resolution genetic map of phenotypes based an analysis 30 subjects carrying rare segmental trisomies various regions HSA21. By using state-of-the-art genomics technologies mapped at exon-level resolution...
Linkage and segregation analysis have shown that circulating angiotensin-I converting enzyme (ACE) levels are influenced by a major quantitative trait locus maps within or close to the ACE gene. The D variant of 287 bp insertion/deletion (I/D) polymorphism in intron 16 gene is associated with high may also be related increased risk cardiovascular disease. Multiple variants linkage disequilibrium I/D been described, but it unknown if any these directly implicated, alone combination as yet...
<i>Objectives:</i> To describe, implement, and test an efficient algorithm to obtain multipoint identity-by-descent (IBD) probabilities at arbitrary positions among marker loci for general pedigrees. Unlike existing programs, our can analyze data sets with large numbers of people markers. The has been implemented in the SimWalk2 computer package. <i>Methods:</i> Using a rigorous testing regimen containing five pedigrees various sizes realistic data, we compared...
Abstract Background Systems biologic approaches such as Weighted Gene Co-expression Network Analysis (WGCNA) can effectively integrate gene expression and trait data to identify pathways candidate biomarkers. Here we show that the additional inclusion of genetic marker allows one characterize network relationships causal or reactive in a chronic fatigue syndrome (CFS) set. Results We combine WGCNA with disease-related pathway its drivers, an analysis which refer "Integrated WGCNA" IWGCNA....
Journal Article A multiple sequence alignment program Get access Eric Sobel, Sobel Department of Biochemistry and Biophysics, University CaliforniaSan Francisco, CA 94143, USA Search for other works by this author on: Oxford Academic PubMed Google Scholar Hugo M. Martinez * To whom correspondence reprint requests should be addressed Nucleic Acids Research, Volume 14, Issue 1, 10 January 1986, Pages 363–374, https://doi.org/10.1093/nar/14.1.363 Published: 1986 history Received: 16 July
Abstract Summary: Mendel is one of the few statistical genetics packages that provide a full spectrum gene mapping methods, ranging from parametric linkage in large pedigrees to genome-wide association with rare variants. Our latest additions anticipate and respond needs community. Compared earlier versions, faster easier use has wider range applications. Supported platforms include Linux, MacOS Windows. Availability: Free www.genetics.ucla.edu/software/mendel Contact: klange@ucla.edu...
We have used pulse-chase experiments to study the time interval between synthesis and assembly of tubulin neurofilament proteins (NFP) in sympathetic neurons grown tissue culture. After varying times, cultures were extracted with Triton X-100 such that polymerized NFP insoluble, while unassembled quantitatively solubilized. The partitioning labeled X-100-soluble or cytoskeletal, fractions was determined an isoelectric focusing X SDS gel electrophoresis assay. Labeled pulse-labeled for 5-10...
Introduction: Neuroplasticity is highest during the first weeks after stroke and can be studied at bedside using EEG. However, brain mapping studies this time are uncommon longitudinal data spaced or months apart, which insufficient to capture neuroplasticity respond therapeutically. Towards goal, a study of frequent EEG was performed in subacute patients deeply understand period. Methods: Post-stroke were included 16 days onset seen four times every 2.1±0.3 (n=2). They paretic hand grip...
Although cardiovascular disease (CVD) and type 2 diabetes mellitus (T2D) share many common risk factors, potential molecular mechanisms that may also be shared for these disorders remain unknown. Using an integrative pathway network analysis, we performed genome-wide association studies in 8155 blacks, 3494 Hispanic American, 3697 Caucasian American women who participated the national Women's Health Initiative single-nucleotide polymorphism (SNP) Association Resource Genomics Randomized...
Statistical genetics is undergoing the same transition to big data that all branches of applied statistics are experiencing. With advent inexpensive DNA sequencing, only accelerating. This brief review highlights some modern techniques with recent successes in statistical genetics. These include: (a) lasso penalized regression and association mapping, (b) ethnic admixture estimation, (c) matrix completion for genotype sequence data, (d) fused copy number variation, (e) haplotyping, (f)...
Abstract This report presents an overview of association testing strategies from a user's perspective, with particular attention to the capabilities computer program Mendel. Association is driven by nature study sample, disease trait, and kind markers employed. The practicing statistician must also choose whether conduct parametric or nonparametric tests. Because complexities involved, Mendel offers users several analysis options. different options are tied together shared input output...
The need to collect accurate and complete pedigree information has been a drawback of family-based linkage association studies. Even in case-control studies, investigators should be aware of, condition on, familial relationships. In single nucleotide polymorphism (SNP) genome scans, relatedness can directly inferred from the genetic data rather than determined through interviews. Various methods estimating have previously implemented, most notably PLINK. We present new fast algorithms for...