Sebastián Díaz-Pérez
A5057551017- Neuroinflammation and Neurodegeneration Mechanisms
- Animal testing and alternatives
- Respiratory viral infections research
- Cell Image Analysis Techniques
- Animal Disease Management and Epidemiology
- Dementia and Cognitive Impairment Research
- Influenza Virus Research Studies
- Acute Ischemic Stroke Management
- Meta-analysis and systematic reviews
- Computational Drug Discovery Methods
- Neurological Disease Mechanisms and Treatments
Yale University
2022-2024
University of Pennsylvania
2017
Significance The majority of influenza vaccine antigens are prepared in chicken eggs. Human strains grown eggs often possess adaptive mutations that increase viral attachment to cells. Most these the hemagglutinin protein, which functions as a factor. Here, we identify mutation current egg-adapted H3N2 strain alters antigenicity. We show ferrets and humans exposed produce antibodies poorly neutralize viruses circulated during 2016–2017 season. These studies highlight challenges associated...
Human diseases may be modeled in animals to allow preclinical assessment of putative new clinical interventions. Recent, highly publicized failures large trials called into question the rigor, design, and value assessment. We established Stroke Preclinical Assessment Network (SPAN) design implement a randomized, controlled, blinded, multi-laboratory trial for rigorous candidate stroke treatments combined with intravascular thrombectomy. Efficacy futility boundaries multi-arm multi-stage...
Cerebral ischemia and reperfusion initiate cellular events in brain that lead to neurological disability. Investigating these provides ample targets for developing new treatments. Despite considerable work, no such therapy has translated into successful stroke treatment. Among other issues—such as incomplete mechanistic knowledge faulty clinical trial design—a key contributor prior translational failures may be insufficient scientific rigor during preclinical assessment: nonblinded outcome...
Abstract Vascular dementia (VaD) refers to a variety of dementias driven by cerebrovascular disease and is the second leading cause globally. VaD may be caused ischemic strokes, intracerebral hemorrhage, and/or cerebral small vessel disease, commonly identified as white matter hyperintensities on MRI. The mechanisms underlying these lesions in periventricular brain are poorly understood. In this study we perform an extensive transcriptomic analysis human postmortem patients with goal...