A5058636673- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- S100 Proteins and Annexins
- Advanced Neuroimaging Techniques and Applications
- Cardiac Arrest and Resuscitation
- Acute Ischemic Stroke Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced MRI Techniques and Applications
- Extracellular vesicles in disease
- Neonatal and fetal brain pathology
- Heart Rate Variability and Autonomic Control
- Stress Responses and Cortisol
- Nanopore and Nanochannel Transport Studies
- MicroRNA in disease regulation
- Fusion and Plasma Physics Studies
- Medical Imaging and Analysis
- Medical research and treatments
- Anesthesia and Neurotoxicity Research
- Trigeminal Neuralgia and Treatments
- Intensive Care Unit Cognitive Disorders
- Child and Adolescent Psychosocial and Emotional Development
- Spaceflight effects on biology
- Migraine and Headache Studies
- Biosensors and Analytical Detection
- Automotive and Human Injury Biomechanics
University of Pennsylvania
2017-2021
Penn Presbyterian Medical Center
2019
Philadelphia University
2018
Jackson Foundation
2017
SUNY Downstate Health Sciences University
2010-2017
California University of Pennsylvania
2017
Uniformed Services University of the Health Sciences
2015
State University of New York
2013
City University of New York
2012
Brooklyn College
2012
Digital droplet assays-in which biological samples are compartmentalized into millions of femtoliter-volume droplets and interrogated individually-have generated enormous enthusiasm for their ability to detect biomarkers with single-molecule sensitivity. These assays have untapped potential point-of-care diagnostics but currently mainly confined laboratory settings, due the instrumentation necessary serially generate, control, measure tens droplets/compartments. To address this challenge, we...
Background There are no drugs presently available to treat traumatic brain injury (TBI). A variety of single have failed clinical trials suggesting a role for drug combinations. Drug combinations acting synergistically often provide the greatest combination potency and safety. The examined (minocycline (MINO), N-acetylcysteine (NAC), simvastatin, cyclosporine A, progesterone) had FDA-approval uses other than TBI limited in experimental models. Methodology/Principal Findings Drugs were dosed...
We developed a platform to isolate brain-derived extracellular vesicles and measure their miRNA biomarkers classify specific states of traumatic brain injury.
Mild traumatic brain injury afflicts over 2 million people annually and little can be done for the underlying injury. The Food Drug Administration-approved drugs Minocycline plus N-acetylcysteine (MINO NAC) synergistically improved cognition memory in a rat mild controlled cortical impact (mCCI) model of injury.3 cellular molecular mechanisms drug combination are unknown. This study addressed effect on white matter damage neuroinflammation after mCCI. Brain tissue from mCCI rats given either...
Traumatic cerebrovascular injury (TCVI) is a common pathologic mechanism of traumatic brain (TBI) and presents an attractive target for intervention. The aims this study were to assess cerebral blood flow (CBF) reactivity (CVR) using magnetic resonance imaging (MRI) their value as biomarkers TCVI in chronic TBI, characterize the spatial distribution TCVI, relationships between each biomarker neuropsychological clinical assessments. Forty-two subjects (27 15 age- gender-matched healthy...
Traumatic cerebral vascular injury (TCVI) is a frequent, but under-recognized, endophenotype of traumatic brain (TBI). It likely contributes to functional deficits after TBI and TBI-related chronic disability, represents an attractive target for targeted therapeutic interventions. The aim this prospective study assess microvascular injury/dysfunction in by measuring reactivity (CVR) 2 methods, magnetic resonance imaging (fMRI) Near InfraRed Spectroscopy (fNIRS) imaging, as each has features...
Abstract Surgery and anesthesia induce inflammatory changes in the central nervous system, which ultimately lead to neuronal damage concomitant with an increase level of neurodegeneration markers. Despite some experimental data showing prolonged activation immune system post-surgery, no study has determined extent long-term elevation The purpose this was investigate serum levels tau protein, ubiquitin carboxyl-terminal hydrolase L1 (UCH-L1), neurofilament light (NF-L), glial fibrillary...
Diffuse axonal injury (DAI) is a hallmark of traumatic brain (TBI) pathology. Recently, the Closed Head Injury Model Engineered Rotational Acceleration (CHIMERA) was developed to generate an experimental model DAI in mouse. The characterization using diffusion tensor magnetic resonance imaging (MRI; imaging, DTI) may provide useful set outcome measures for preclinical and clinical studies. objective this study identify complex neurobiological underpinnings DTI features following...
Blunt impact produces a heterogeneous brain injury in people and animal models of traumatic injury. We report that single closed head to adult C57/BL6 mice produced two syndromes (CHI-1 CHI-2). CHI-1 spontaneously reinitiated breathing after while CHI-2 had prolonged apnea regained only cardiopulmonary resuscitation supplementation 100% O2. The group significantly righting reflex more rapidly than the group. At 7 days post-injury, CHI-1, but not mice, acquired no long-term retention an...
Mild traumatic brain injury does not currently have a clear molecular diagnostic panel to either confirm the or guide its treatment. Current biomarkers for rely mainly on detecting circulating proteins in blood that are associated with degenerating neurons, which less common mild injury, broad inflammatory cascades produced multiple tissues and thus specific. To address this issue, we conducted an observational cohort study designed measure protein two compartments-plasma brain-derived...
The neuropathology of traumatic brain injury (TB) is diverse, including primary to neurons, axons, glial cells, vascular structures, and secondary processes, such as edema inflammation that vary between individual patients. Traumatic microvascular an important endophenotype TBI-related injury. We studied patients who sustained a TBI requiring ER evaluation had MRI performed within 48 h classified into 3 groups based on their findings: (1) those evidence susceptibility or diffusion weighted...
Abstract Background Traumatic cerebrovascular injury ( TCVI ), a common consequence of traumatic brain TBI presents an attractive therapeutic target. Because phosphodiesterase‐5 PDE 5) inhibitors potentiate the action nitric oxide NO ) produced by endothelial cells, they are candidate therapies for . This study aims to: (1) measure cerebral blood flow CBF reactivity CVR and change in after single dose sildenafil (Δ chronic compared to uninjured controls; (2) examine safety tolerability...
Magnetic resonance imaging (MRI) is a powerful tool for visualizing traumatic brain injury(TBI)-related lesions. Trauma-induced encephalomalacia frequently identified by its hyperintense appearance on fluid-attenuated inversion recovery (FLAIR) sequences. In addition to parenchymal lesions, TBI commonly results in cerebral microvascular injury, but anatomical relationship not well characterized. The current study utilized multi-modal MRI protocol assess microstructural tissue integrity (by...
Traumatic Brain Injury (TBI) is associated with both diffuse axonal injury (DAI) and vascular (DVI), which result from inertial shearing forces. These terms are often used interchangeably, but the spatial relationships between DAI DVI have not been carefully studied. Multimodal magnetic resonance imaging (MRI) can help distinguish these mechanisms: diffusion tensor (DTI) provides information about integrity, while arterial spin labeling (ASL) be to measure cerebral blood flow (CBF),...
The authors attempted to reduplicate the Lacey phenomenon of heart rate acceleration during performance an interiorized mental task and its maintenance in time. For this purpose they resorted pavlovian conditioning paradigm. heart-rate response was obtained repetitively thanks a change structure and/ or content conditioned elicited some subjects. Moreover, other types visceral were evidenced. underline importance such factors as anxiety, personality intellectual abilities sort conditioning.
To compare brain parenchymal volumes and cerebrovascular reactivity (CVR) among chronic moderate/severe TBI patients compared to age- gender-matched healthy controls.
April 27, 2018April 10, 2018Free AccessVascular reactivity and microstructural changes association with neurocognitive symptoms in chronic traumatic brain injury (S49.001)Sarah Woodson, Margalit Haber, Franck Amyot, Kelley Fleshner, Erika Silverman, Kimbra Kenney, Carol Moore, Yi-Yu Chou, Dzung Pham, Michael Sangobowale, Ramon Diaz-ArrastiaAuthors Info & AffiliationsApril 2018 issue90 (15_supplement)https://doi.org/10.1212/WNL.90.15_supplement.S49.001 Letters to the Editor