Samuel A. McLean
A5055323138- Musculoskeletal pain and rehabilitation
- Posttraumatic Stress Disorder Research
- Traumatic Brain Injury Research
- Cardiac Arrest and Resuscitation
- Pediatric Pain Management Techniques
- Stress Responses and Cortisol
- Resilience and Mental Health
- Trauma and Emergency Care Studies
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Child Abuse and Trauma
- Emergency and Acute Care Studies
- Migration, Health and Trauma
- Pain Mechanisms and Treatments
- Sexual Assault and Victimization Studies
- Pain Management and Opioid Use
- Psychosomatic Disorders and Their Treatments
- Pain Management and Placebo Effect
- Pregnancy-related medical research
- Anesthesia and Neurotoxicity Research
- Opioid Use Disorder Treatment
- Burn Injury Management and Outcomes
- Spine and Intervertebral Disc Pathology
- Health, Medicine and Society
- Traumatic Brain Injury and Neurovascular Disturbances
- Anesthesia and Pain Management
University of North Carolina at Chapel Hill
2016-2025
University of North Carolina Health Care
2010-2024
Emory University
2021-2024
University of Iowa
2023
Park Terrace Care Center
2023
McLean Hospital
2021-2022
Zhejiang University
2022
North Carolina State University
2022
University of Toronto
2022
University of Cape Town
2022
The underlying neurophysiology of acute pain is fairly well characterized, whereas the central mechanisms operative in chronic states are less understood. Fibromyalgia (FM), a common condition characterized by widespread pain, thought to originate largely from altered neurotransmission. We compare sample 17 FM patients and age- sex-matched healthy controls, using mu-opioid receptor (MOR) positron emission tomography. demonstrate that display reduced MOR binding potential (BP) within several...
Post-traumatic stress disorder (PTSD) should be one of the most preventable mental disorders, since many people exposed to traumatic experiences (TEs) could targeted in first response settings immediate aftermath exposure for preventive intervention. However, these interventions are costly and proportion TE-exposed who develop PTSD is small. To cost-effective, risk prediction rules needed target high-risk a TE. Although number studies have been carried out examine prospective predictors...
Abstract Objective Fibromyalgia (FM) is a chronic widespread pain condition that thought to arise from augmentation of central neural activity. Glutamate (Glu) an excitatory neurotransmitter functions in pain‐processing pathways. This study was carried out investigate the relationship between changing levels Glu within insula and changes multiple domains patients with FM. Methods Ten FM underwent 2 sessions proton magnetic resonance spectroscopy (H‐MRS) functional imaging (FMRI), each...
Abstract Objective To compare the momentary association between salivary cortisol levels and pain, fatigue, stress symptoms in patients with fibromyalgia (FM), to diurnal cycles of secretion FM healthy control subjects a naturalistic environment. Methods Twenty‐eight 27 completed assessments on symptoms, 5 times day for 2 consecutive days, while engaging usual daily activities. Only those participants who adhered protocol (assessed via activity monitor) were included final analyses. Results...
Three common haplotypes in the gene encoding catechol-O-methyltransferase (COMT) have been associated with pain modulation and risk of developing chronic musculoskeletal pain, namely temporomandibular disorder (TMD). Haplotypes coding for higher enzymatic activity were correlated lower perception. Rodent studies showed that COMT inhibition increases sensitivity through beta2/3-adrenergic receptors. We hypothesized nonselective beta-adrenergic antagonist propranolol will reduce clinical...
Background Preclinical studies suggest that opioids may promote tumor growth. Genetic polymorphisms have been shown to affect opioid receptor function and modify the clinical effects of morphine. In this study we assessed association between six common in μ-opioid gene, including well known A118G polymorphism, breast cancer survival. Methods A total 2,039 women ages 23-74 yr (38% African-American, 62% European-American, 55% postmenopausal) diagnosed with 1993-2001 were followed through 2006....
Major negative life events, such as trauma exposure, can play a key role in igniting or exacerbating psychopathology. However, few disorders are diagnosed with respect to precipitating and the of these events unfolding new psychopathology is not well understood. The authors conducted multisite transdiagnostic longitudinal study exposure related mental health outcomes identify neurobiological predictors risk, resilience, different symptom presentations.
Objective: Dissociation, a disruption or discontinuity in psychological functioning, is often linked with worse psychiatric symptoms; however, the prognostic value of dissociation after trauma inconsistent. Determining whether trauma-related uniquely predictive later outcomes would enable early identification at-risk populations. The authors conducted largest prospective longitudinal biomarker study persistent to date determine its capacity for adverse following acute trauma. Methods: All...
Abstract Objective A growing body of evidence suggests that real‐time electronic assessments pain are preferable to traditional paper‐and‐pencil measures. We used assessment data derived from a study patients with fibromyalgia (FM) examine variability over time and investigate the implications fluctuation in context clinical trial. Methods The group comprised 125 FM who were enrolled randomized, placebo‐controlled trial milnacipran. Pain intensity levels captured real by participants using...
Debate continues regarding the influence of litigation on pain outcomes after motor vehicle collision (MVC). In this study we enrolled European Americans presenting to emergency department (ED) in hours MVC (n=948). Six weeks later, participants were interviewed symptoms and asked about their participation MVC-related litigation. The incidence predictors neck widespread 6weeks compared among those engaged (litigants) not (nonlitigants). Among 859 948 (91%) completing 6-week follow-up, 711...
Abstract Background Cross‐sectional studies have shown that chronic musculoskeletal pain and somatic symptoms are frequently reported by sexual assault ( SA ) survivors; however, prospective examining in the months after not been performed. Methods Women survivors 18 years of age or older who presented for care within 48 h were recruited. Pain eight body regions (head face, neck, breast, arms, abdomen, back, genital pelvic, legs) 21 common (e.g., headache, nausea, insomnia, persistent...
•Significant numbers of patients still suffer from significant acute pain, despite the advent modern multimodal analgesic strategies.•Mismanaged pain has a broad societal impact, as may progress to chronic pain.•An taxonomy provides much needed standardization clinical diagnostic criteria which benefits care, research, education, and public policy.•For purposes present taxonomy, is considered last up 7 days with prolongation 30 being common.•Current understanding mechanisms poorly...
Considerable racial/ethnic disparities persist in exposure to life stressors and socioeconomic resources that can directly affect threat neurocircuitry, particularly the amygdala, partially mediates susceptibility adverse posttraumatic outcomes. Limited work date, however, has investigated potential variability amygdala reactivity or connectivity may turn be related outcomes such as post-traumatic stress disorder (PTSD). Participants from AURORA study (n = 283), a multisite longitudinal of...
Abstract Background Psychological trauma exposure and posttraumatic stress disorder (PTSD) have been associated with advanced epigenetic age. However, whether aging measured at the time of predicts subsequent development PTSD outcomes is unknown. Moreover, neural substrates underlying are unclear. Methods We examined a multi-ancestry cohort women men ( n = 289) who presented to emergency department (ED) after trauma. Blood DNA was collected ED presentation, EPIC methylation arrays were used...
Abstract Patients exposed to trauma often experience high rates of adverse post-traumatic neuropsychiatric sequelae (APNS). The biological mechanisms promoting APNS are currently unknown, but the microbiota-gut-brain axis offers an avenue understanding as well possibilities for intervention. Microbiome composition after exposure has been poorly examined regarding outcomes. We aimed determine whether gut microbiomes trauma-exposed emergency department patients who develop have dysfunctional...