A5008457899- Anesthesia and Pain Management
- Cardiac Ischemia and Reperfusion
- Cardiac, Anesthesia and Surgical Outcomes
- Spine and Intervertebral Disc Pathology
- Anesthesia and Neurotoxicity Research
- Pain Management and Opioid Use
- Anesthesia and Sedative Agents
- Cardiac Arrest and Resuscitation
- Mitochondrial Function and Pathology
- Bladder and Urothelial Cancer Treatments
- Enhanced Recovery After Surgery
- Musculoskeletal pain and rehabilitation
- Pain Management and Treatment
- Intraoperative Neuromonitoring and Anesthetic Effects
- Head and Neck Cancer Studies
- Urinary Bladder and Prostate Research
- Fatty Acid Research and Health
- Cardiovascular Function and Risk Factors
- Urinary and Genital Oncology Studies
- Pediatric Pain Management Techniques
- Cardiovascular Syncope and Autonomic Disorders
- Nausea and vomiting management
- Intensive Care Unit Cognitive Disorders
- Metabolism and Genetic Disorders
- Fuel Cells and Related Materials
UCLA Health
2010-2025
University of California, Los Angeles
2012-2025
Sheffield Teaching Hospitals NHS Foundation Trust
2024
Yale University
2022
Ronald Reagan UCLA Medical Center
2011-2021
Los Angeles Medical Center
2020
Creative Commons
2016
APLA Health
2014
Kaiser Permanente
2013
Kaiser Permanente West Los Angeles Medical Center
2011
The United States is in the midst of an opioid epidemic, and use disorder often begins with a prescription for acute pain. perioperative period represents important opportunity to prevent chronic use, recently there has been paradigm shift toward implementation enhanced recovery after surgery (ERAS) protocols that promote opioid-free multimodal analgesia. objective this study was assess impact ERAS intervention colorectal on discharge prescribing practices.We conducted historical-prospective...
Background Intralipid (Sigma, St. Louis, MO), a brand name for the first safe fat emulsion human use, has been shown to be cardioprotective. However, mechanism of this protection is not known. The authors investigated molecular mechanism(s) Intralipid-induced cardioprotection against ischemia/reperfusion injury, particularly role glycogen synthase kinase-3β (GSK-3β) and mitochondrial permeability transition pore in protective action. Methods In vivo rat hearts or isolated...
Objectives: Lipid emulsion has been shown to be effective in resuscitating bupivacaine-induced cardiac arrest but its mechanism of action is not clear. Here we investigated whether fatty-acid oxidation required for rescue cardiotoxicity by lipid rats. We also compared the mitochondrial function and calcium threshold triggering permeability transition pore opening before after resuscitation with emulsion. Design: Prospective, randomized animal study. Setting: University research laboratory....
Novel therapies aimed at modulating the autonomic nervous system, including thoracic epidural anesthesia (TEA), have been shown in small case series to be beneficial treating medically refractory ventricular tachycardia (VT) storm. However, it is not clear when these options should considered. We reviewed a multicenter experience with TEA management of VT storm determine its optimal therapeutic use.Data for 11 patients whom was instituted between July 2005 and March 2016 were clinical...
We have recently shown that postischemic administration of intralipid protects the heart against ischemia-reperfusion injury. Here we compared cardioprotective effects with cyclosporine-A, a potent inhibitor mitochondrial permeability transition pore opening.In vivo rat hearts or isolated Langendorff-perfused mouse were subjected to ischemia followed by reperfusion (0.5%, 1% and 2% ex-vivo, 20% in vivo), cyclosporine-A (0.2 μM, 0.8 1.5 μM ex- 10 mg/kg vehicle. The hemodynamic function,...
•Significant numbers of patients still suffer from significant acute pain, despite the advent modern multimodal analgesic strategies.•Mismanaged pain has a broad societal impact, as may progress to chronic pain.•An taxonomy provides much needed standardization clinical diagnostic criteria which benefits care, research, education, and public policy.•For purposes present taxonomy, is considered last up 7 days with prolongation 30 being common.•Current understanding mechanisms poorly...
With the increasing societal awareness of prevalence and impact acute pain, there is a need to develop an pain classification system that both reflects contemporary mechanistic insights helps guide future research treatment. Existing classifications conditions are limiting, with predominant focus on sensory experience (e.g., intensity) pharmacologic consumption. Consequently, more broadly characterize classify multidimensional pain.Consensus report following expert panel involving Analgesic,...
Management of refractory ventricular fibrillation (VF) in patients with implantable cardioverter defibrillator (ICD) presents a therapeutic challenge. We present case pediatric tachycardia (VT)/Torsade de Pointe managed effectively bilateral stellate ganglion block (SGB) long-acting local anesthetic for 18 days as bridge to more definitive surgical management.
Determining the superior cervical ganglion's precise anatomical location for local anesthetic block, when stellate block is not feasible or contraindicated, difficult.We dissected ganglion in 60 embalmed cadaveric specimens. Multiple regressions determined whether subject characteristics predicted distance between and common carotid artery bifurcation dimensional width area. Based on these regressions, we mapped using a pseudocolor statistical heat map.The model significantly ganglion-common...
Objectives The aim of this study was to evaluate the impact epidural analgesia (EA) on postoperative length stay (LOS), expeditious discharge, and pain relief after pancreaticoduodenectomy (PD) distal pancreatectomy (DP). Methods Retrospective reviews 2014–2015 American College Surgeons National Surgical Quality Improvement Program databases our institutional pancreatic surgery database were conducted. Results On univariate analysis, EA associated with statistically significant longer...
Lipid emulsion (LE) has been successfully used for resuscitation of local anesthetic cardiotoxicity caused by bupivacaine overdose. Opioid receptors have shown to play a key role in cardio protection. We explored whether this rescue action LE is mediated through opioid receptors.Asystole was induced (10 mg/kg over 20 seconds, IV) young male Sprague-Dawley rats, and with (intralipid 20%; 5 mL/kg bolus 0.5 mL/kg/min maintenance) started immediately. The rats were pretreated 2 minutes before...
Abstract Perioperative pain management is an important consideration in early recovery and patient satisfaction following laparoscopic donor nephrectomy. Transmuscular quadratus lumborum block has been described to reduce opioid usage several abdominal surgeries. In this prospective single‐blind randomized controlled trial, we compared 52 patients who adhered our institutional nephrectomy Early Recovery After Surgery pathway, which includes a laparoscopic‐guided transversus abdominus plane...
Surv Anesthesiol 2016;60(2):78–79 Lipid rescue, or lipid emulsion (LE), has been shown to resuscitate patients from cardiac-related effects of local anesthetics and toxicities caused by a wide range drugs, such as calcium channel blockers, β-blockers, psychoactive agents. Using nonselective opioid receptor antagonists (ORAs) highly selective ORAs, the authors this study examined whether rescue action LE is mediated through central peripheral receptors.