A5100367205- Acute Kidney Injury Research
- Cardiac Fibrosis and Remodeling
- Adipose Tissue and Metabolism
- Apelin-related biomedical research
- Hormonal Regulation and Hypertension
- Renin-Angiotensin System Studies
- Nutrition and Health in Aging
- Magnolia and Illicium research
- Traumatic Brain Injury and Neurovascular Disturbances
- Lipid metabolism and biosynthesis
- Body Composition Measurement Techniques
- Heart Failure Treatment and Management
- Cytokine Signaling Pathways and Interactions
- Circadian rhythm and melatonin
- Frailty in Older Adults
- Cardiac Ischemia and Reperfusion
- Receptor Mechanisms and Signaling
- Endoplasmic Reticulum Stress and Disease
- Sirtuins and Resveratrol in Medicine
- Signaling Pathways in Disease
- Dialysis and Renal Disease Management
- Cardiac Arrest and Resuscitation
- RNA Research and Splicing
- Nitric Oxide and Endothelin Effects
- Anesthesia and Neurotoxicity Research
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2025
Shandong University
2021
Qilu Hospital of Shandong University
2017-2020
Flinders Medical Centre
2015
University of California, Los Angeles
2012
Objectives: Lipid emulsion has been shown to be effective in resuscitating bupivacaine-induced cardiac arrest but its mechanism of action is not clear. Here we investigated whether fatty-acid oxidation required for rescue cardiotoxicity by lipid rats. We also compared the mitochondrial function and calcium threshold triggering permeability transition pore opening before after resuscitation with emulsion. Design: Prospective, randomized animal study. Setting: University research laboratory....
Human antigen R (HuR) is a member of the Hu family RNA-binding proteins and involved in many physiological processes. Obesity, as worldwide healthcare problem, has attracted more attention. To investigate role adipose HuR, we generate adipose-specific HuR knockout (HuRAKO) mice. As compared with control mice, HuRAKO mice show obesity when induced high-fat diet, along insulin resistance, glucose intolerance, hypercholesterolemia increased inflammation tissue. The attributed to adipocyte...
Oxidative stress and apoptosis play a vital role in the pathogenesis of contrast-induced acute kidney injury (CI-AKI). The purpose our study was to investigate protective effects mechanisms melatonin against CI-AKI mouse model NRK-52E cells. We established mice, animals were pretreated with (20 mg/kg). Our results demonstrated that treatment exerted renoprotective effect by decreasing level serum creatinine (SCr) blood urea nitrogen (BUN), lessening histological changes renal tubular...
Smoking is a major preventable risk factor for atherosclerosis. However, the causative link between cigarette smoke and atherosclerosis remains to be established. The objective of this study characterize role GTP cyclohydrolase 1 (GTPCH1), rate-limiting enzyme de novo tetrahydrobiopterin (BH4) synthesis, in smoking-accelerated mechanism involved. In vitro, human umbilical vein endothelial cells were treated with nicotine, component smoke, which reduced mRNA protein levels GTPCH1 led...
Renal fibrosis participates in the progression of hypertension-induced kidney injury. The effect SIRT3, a member NAD+-dependent deacetylase family, hypertensive nephropathy remains unclear. In this study, we found that SIRT3 was reduced after angiotensin II (AngII) treatment both vivo and vitro. Furthermore, SIRT3-knockout mice aggravated renal dysfunction via chronic AngII infusion (2000 ng/kg per minute for 42 days). On contrary, SIRT3-overexpression attenuated AngII-induced injury...
Highlights•ZFP36 downregulation in adipose tissues of humans and mice is linked to obesity metabolic disorders.•Adipose ZFP36 deficiency exacerbates diet-induced syndrome mice.•The expansion adipocytes contributes tissue hypoxia, leading dysfunction obesity.•ZFP36 attenuates hypertrophy white via RNF128/Sirt1/lipolysis signaling.AbstractAimsObesity, as a worldwide healthcare problem, has become more prevalent. well-known RNA-binding protein involved the posttranscriptional regulation many...
Objective: Melatonin, an endogenous neurohormone secreted predominately by the pineal gland, has a variety of physiological functions. However, its protective role in atherosclerosis is not clear. In this study, we sought to investigate potential effects melatonin modulating atherosclerotic plaque stability apolipoprotein E knockout (ApoE-/-) mice. Method and results: Smooth muscle cells were treated with melatonin, which significantly increased mRNA protein levels key intracellular enzyme...
Abstract Obesity and the associated complications are a major public health issue as obesity incidence increases yearly, worldwide. Effects of on heart failure have been reported previously. Obesity-related cardiac remodeling includes structural functional dysfunctions, in which inflammation fibrosis play key role. The main mitochondrial deacetylase, SIRT3 participates numerous cellular processes; however, its role obesity-related remains unclear. In our study, high-fat diet (HFD) feeding...
Background: Long-staying medical inpatients carry a significant burden of acute and chronic illness. Prediction their in-hospital longer-term mortality risk is important. Aim: The aim this study was to determine what extent creatinine variability predicts 1-year in inpatients. Design: Retrospective cohort analysis. Methods: Patients were included if aged 18 years or older admitted for 7 days longer. main outcome variables hospital after discharge. Results: Increasing age, the presence heart...